ID A0A340X5R3_LIPVE Unreviewed; 797 AA.
AC A0A340X5R3;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
GN Name=SLC9A4 {ECO:0000313|RefSeq:XP_007456903.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007456903.1};
RN [1] {ECO:0000313|RefSeq:XP_007456903.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|ARBA:ARBA00007367,
CC ECO:0000256|RuleBase:RU003722}.
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DR RefSeq; XP_007456903.1; XM_007456841.1.
DR STRING; 118797.A0A340X5R3; -.
DR GeneID; 103080305; -.
DR KEGG; lve:103080305; -.
DR CTD; 389015; -.
DR InParanoid; A0A340X5R3; -.
DR OrthoDB; 1065060at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR Gene3D; 6.10.250.1040; -; 1.
DR Gene3D; 6.10.250.2020; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004709; NaH_exchanger.
DR InterPro; IPR032103; NHE_CaM-bd.
DR NCBIfam; TIGR00840; b_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF103; SODIUM_HYDROGEN EXCHANGER 4; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF16644; NEXCaM_BD; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU003722};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU003722};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Signal {ECO:0000256|SAM:SignalP}; Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003722}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..797
FT /note="Sodium/hydrogen exchanger"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016387364"
FT TRANSMEM 96..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 74..476
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 567..672
FT /note="Sodium/hydrogen exchanger regulatory region"
FT /evidence="ECO:0000259|Pfam:PF16644"
FT REGION 757..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..786
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 797 AA; 89834 MW; 1B324DF0022E9F06 CRC64;
MGFQMLAPFG PWNWLFLLMA LKCGGASSDL NESTNSSAQH ELNVRFAAAS SEPAETVSVF
ALDYDYVQIP YEVTLWILLA SLAKIGFHLY HRLPGLMPES CLLILVGALV GAIIFGTHHK
SPPVMDSSIY FLYLLPPIVL EGGYFMPTRP FFENIGSILW WAGLGALINA FGIGLSLYLI
CQVQAFGLSD VNLLQNLLFG SLISAVDPVA VLAVFEEARV NQQLYMMIFG EALLNDGISV
VLYNILIAFT KMHKFEDIEP VDILAGCARF IIVGCGGVFF GVIFGFISAF ITRFTQNISA
IEPLIVFMFS YLSYLVAETL YLSGILAITA CAVTMKKYVE ENVSQTSNTT IKYFMKMLSS
VSETLIFIFM GVSTVGKNHE WNWAFVCFTL AFCQIWRAIS VFALFYISNQ FRTFPFSIKD
QCIIFYSGVR GAGSFSLAFL LPLSLFPRKK MFVTATLVVI YFTVFIQGIT IGPLVRYLDV
RKTNKKESIN EELHTRLMDH LKAGIEDVCG QWSHYQVRDK FKKFDHKYLR KILIRENLPK
SSIVSLYKKL EMKQAIEMAE TGILSSTAFS MPHQAQRIQE TKRLSPEDVE SMRDILTHNM
YQVRQRALSY NKYNLKPQTS EKQAKEILIR RQNTFRESAR KGHSLPWGKP AGTKNIRYCS
FPYSHPQPAG RDVRVAEFTD HDGSDAEVPS IMFNTHSPTG SLQEGRRTQE IIPLMNLHRG
GKPAHLGYQR NRSQEEQLGG GRRVVLXXXP LFRAVDEDFE SGEKSEEEAS AIGSRWSAEH
RPGRDLQGSH SPLLQSK
//
