UniProt: A0A340X601

Database: UniProt
Entry: A0A340X601_LIPVE

LinkDB:  A0A340X601_LIPVE 
Original site:  A0A340X601_LIPVE

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Ontology (5)   
   GO (5)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (25)   
   InterPro (14)   
   Pfam (7)   
   PROSITE (1)   
   SMART (3)   
All databases (33)   

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ID   A0A340X601_LIPVE        Unreviewed;      1893 AA.
AC   A0A340X601;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Plexin-A4 isoform X1 {ECO:0000313|RefSeq:XP_007455417.1};
GN   Name=PLXNA4 {ECO:0000313|RefSeq:XP_007455417.1};
OS   Lipotes vexillifer (Yangtze river dolphin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Lipotidae; Lipotes.
OX   NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007455417.1};
RN   [1] {ECO:0000313|RefSeq:XP_007455417.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC   -!- SIMILARITY: Belongs to the plexin family.
CC       {ECO:0000256|ARBA:ARBA00010297}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   RefSeq; XP_007455417.1; XM_007455355.1.
DR   GeneID; 103075911; -.
DR   KEGG; lve:103075911; -.
DR   CTD; 91584; -.
DR   OrthoDB; 1387371at2759; -.
DR   Proteomes; UP000265300; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00603; IPT_PCSR; 1.
DR   CDD; cd01180; IPT_plexin_repeat1; 1.
DR   CDD; cd01179; IPT_plexin_repeat2; 1.
DR   CDD; cd01181; IPT_plexin_repeat3; 1.
DR   CDD; cd12790; RasGAP_plexin_A; 1.
DR   CDD; cd11274; Sema_plexin_A4; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR031148; Plexin.
DR   InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR   InterPro; IPR046800; Plexin_RBD.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR041019; TIG1_plexin.
DR   InterPro; IPR041362; TIG2_plexin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR22625; PLEXIN; 1.
DR   PANTHER; PTHR22625:SF34; PLEXIN-A4; 1.
DR   Pfam; PF08337; Plexin_cytopl; 1.
DR   Pfam; PF20170; Plexin_RBD; 1.
DR   Pfam; PF01437; PSI; 3.
DR   Pfam; PF01403; Sema; 1.
DR   Pfam; PF01833; TIG; 4.
DR   Pfam; PF18020; TIG_2; 1.
DR   Pfam; PF17960; TIG_plexin; 1.
DR   SMART; SM00429; IPT; 4.
DR   SMART; SM00423; PSI; 3.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF81296; E set domains; 4.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF103575; Plexin repeat; 2.
DR   SUPFAM; SSF101912; Sema domain; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|ARBA:ARBA00022777};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..1893
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016409094"
FT   TRANSMEM        1237..1259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          23..506
FT                   /note="Sema"
FT                   /evidence="ECO:0000259|PROSITE:PS51004"
FT   COILED          1263..1290
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1893 AA;  212515 MW;  A9CA1EAF5C1080FD CRC64;
     MKAMPWNWTC LLSHLLMVGM GSSTLLPQQP PLLPQKRSFV TFRGEPAESF NHLVVDERTG
     HIYVGAVNRI YKLSSDLKVL VTHQTGPDED NPKCYPPRIV QTCNEPLTTT NNVNKMLLID
     YKENRLIACG SLYQGICKLL RLEDLFKLGE PFHKKEHYLS GVNESGSVFG VIVSYNNLDD
     KLFIATAVDG KPEYFPTISS RKLTKNSEAD GMFAYVFHDE FVASMIKIPS DTFTVIPDFD
     IYYVYGFSSG NFVYFLTLQP EMVSPPGSTT KEQVYTSKLV RLCKEDTAFN SYVEVPIGCE
     HGGVEYRLLQ AAYLSKAGAV LARTLGVRPE DDLLFTVFSK GQKRKMKSLD ESALCIFVLK
     QINDRIKERL QSCYRGEGTL DLAWLKVKDI PCSSALLTID DNFCGLDMNA PLGVSEMVRG
     IPVFTEDRDR MTSVIAYVYK NHSLAFVGTK SGKLKKIRVD GPRGNALQYE TVQVVDPGPV
     LRDMAFSKDH KQLYIMSERQ LTRVPVESCG QYRSCGECLG SGDPHCGWCV LHNTCTRKER
     CERSREPRRF ASEMKQCVRL TVHPSNISVS QYNVLLVLET YNVPELSAGV SCTFEDLSEM
     DGLVVGSQIQ CHSPAAKEVP RIITENGDHH VVQLQLKSKE TGMTFASTSF VFYNCSVHNS
     CLSCVESPYR CHWCKYRHVC THDPKTCSFQ EGRVRLPEDC PQLLRVDKIL VPVEVIKPIT
     LKAKNLPQPQ SGQRGYECIL SIQGSEQRVP ALRFNSSSVQ CQNTSYSYEG MEINNLPVKL
     TVVWNGHFNI DNPAQNKVHL YKCGAMRESC GLCLKADPDF ECGWCQGQGQ CTLRQHCPIH
     ESHWLELSGT NSKCTNPRIT EIIPVTGPRE GGTKVTIRGE NLGLEFRDIA SHVKVAGVEC
     SPLVDGYIPA EQIVCEMGEA KPSQHAGFVE ICVAVCRPEF MARSSQLYYF MTLTLSDLKP
     SRGPMSGGTQ VTITGTNLNA GSNVVVMFGK QPCLFHRRSP SYIVCNTTSS DEVLEMKVMV
     QVDRAKIHQD LFFQYMEDPT IVRIEPEWSI ISGNTPIAVR GTHLDLIQNP QIRAKHGGKE
     HINLCEVLNA TEMTCQAPAL ALGPDHQSDL TERPEEFGFI LDNVQSLLIL NKTNFTYYPN
     PVFEAFGPSG ILELKPGTPI ILKGKNLIPP VAGGNVKLNY TVLVGEKPCT VTVSDVQLLC
     ESPNLIGRHK VMARVGGMEY SPGMVYIAPD SPLSLPAIVS IAVAGGLLII FIVAVLIAYK
     RKSRESDLTL KRLQMQMDNL ESRVALECKE AFAELQTDIH ELTSDLDGAG IPFLDYRTYT
     MRVLFPGIED HPVLRDLEVP GYRQERVEKG LKLFAQLINN KACLLSFIRT LESQRSFSMR
     DRGNVASLIM TVLQSKLEYA TDVLKQLLAD LIDKNLESKN HPKLLLRRTE SVAEKMLTNW
     FTFLLYKFLK ECAGEPLFSL FCAIKQQMEK GPIDAITGEA RYSLSEDKLI RQQIDYKTLV
     LSCVNPDNAN SPEVPVKILN CDTITQVKEK ILDAIFKNVP CSHRPKAADM DLEWRQGSGA
     RMILQDEDIT TKIENDWKRL NTLAHYQVPD GSVVALVSKQ VTAYNAVNNS TISRTSASKY
     ENMIRYTGSP DSLRSRTPMI TPDLESGVKM WHLVKNHEHG DQKEGDRGSK MVSEIYLTRL
     LATKGTLQKF VDDLFETIFS TAHRGSALPL AIKYMFDFLD EQADKHGIHD PHVRHTWKSN
     CLPLRFWVNM IKNPQFVFDI HKNSITDACL SVVAQTFMDS CSTSEHRLGK DSPSNKLLYA
     KDIPSYKNWV ERYYSDIGKM PAISDQDMNA YLAEQSRMHV NEFNTMSALS EIFSYVGKYS
     EEILGPLDHD DQCGKQKLAY KLEQVITLMS LDS
//

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