ID A0A340X649_LIPVE Unreviewed; 830 AA.
AC A0A340X649;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Protein Jade-1 {ECO:0000256|ARBA:ARBA00040212};
DE AltName: Full=Jade family PHD finger protein 1 {ECO:0000256|ARBA:ARBA00041998};
DE AltName: Full=PHD finger protein 17 {ECO:0000256|ARBA:ARBA00042970};
GN Name=JADE1 {ECO:0000313|RefSeq:XP_007457048.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007457048.1};
RN [1] {ECO:0000313|RefSeq:XP_007457048.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000256|ARBA:ARBA00004120}.
CC -!- SIMILARITY: Belongs to the JADE family.
CC {ECO:0000256|ARBA:ARBA00038371}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007457048.1; XM_007456986.1.
DR AlphaFoldDB; A0A340X649; -.
DR GeneID; 103085156; -.
DR CTD; 79960; -.
DR OrthoDB; 163389at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15671; ePHD_JADE; 1.
DR CDD; cd15679; PHD_JADE1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR039546; Jade-1_PHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR PANTHER; PTHR13793:SF79; PROTEIN JADE-1; 1.
DR Pfam; PF10513; EPL1; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 191..241
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 243..357
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..368
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..681
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..790
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 830 AA; 94156 MW; 0819E8AC8A215A14 CRC64;
MKRGRLPSSS EDSDDNGSLS TTWSQNSRSQ HRRSSCSRHE DRKPSEVFRT DLITAMKLHD
SYQLNPDEYY VLADPWRQEW EKGVQVPVSP GTIPQPVARP KKYIVSSGSE PPELGYVDIR
TLADSVCRYD LNDMDAAWLE LTNEEFKEMG MPELDEYTME RVLEEFEQRC YDNMNHAIET
EEGLGIEYDE DVVCDVCQSP DGEDGNEMVF CDKCNICVHQ ACYGILKVPE GSWLCRTCAL
GVQPKCLLCP KKGGAMKPTR SGTKWVHVSC ALWIPEVSIG SPEKMEPITK VSHIPSSRWA
LVCSLCNEKF GASIQCSVKN CRTAFHVTCA FDRGLEMKTI LAENDEVKFK SYCPKHSSHR
KPDESLGEGA ARENGAPECP PRDPLEPFGS LEQNQEEAHR VSVRKQKLQQ LEDEFYTFVN
LLDVARALRL PEEVVDFLYQ YWKLKRKVNF NKPLITPKKD EEDNLAKREQ DVLFRRLQLF
THLRQDLERV RNLTYMVTRR EKIKRSVCKV QEQIFNLYTK LLEQERVSGA PPSSSSSSLE
NMLLFNSPSV GPDAPKIEDL KWHSAFFRKQ MGTSLVHSMK KPHKRDPLQN SAGSEGKTLL
KQPDLCSRRE GMVVPESFLS FEKTFAEARL ISAQQKNGVV MPDHGNRRDH RFHCDLGKGD
LKDRPFKQSH KPLRSTDVSQ RHVDNTRAAT SPGVGQSAPG TRKEMVPKCN GSLIKVNYNQ
TAVKVPTTPA SPVKNWGGFR IPKKGERQQQ GEAHEGACHQ HSDYPYLGLG RVPAKERAKS
KLKSDNENDG YVPDVEMSDS ESEASEKKCI HASSTINRRT DIIRRSILAS
//
