UniProt: A0A340X6T6

Database: UniProt
Entry: A0A340X6T6_LIPVE

LinkDB:  A0A340X6T6_LIPVE 
Original site:  A0A340X6T6_LIPVE

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Ontology (5)   
   GO (5)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (21)   
   InterPro (11)   
   Pfam (5)   
   PROSITE (3)   
   SMART (2)   
All databases (29)   

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ID   A0A340X6T6_LIPVE        Unreviewed;      1179 AA.
AC   A0A340X6T6;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Integrin alpha-1 isoform X1 {ECO:0000313|RefSeq:XP_007457263.1};
GN   Name=ITGA1 {ECO:0000313|RefSeq:XP_007457263.1};
OS   Lipotes vexillifer (Yangtze river dolphin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Lipotidae; Lipotes.
OX   NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007457263.1};
RN   [1] {ECO:0000313|RefSeq:XP_007457263.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC       ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC       {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR   RefSeq; XP_007457263.1; XM_007457201.1.
DR   AlphaFoldDB; A0A340X6T6; -.
DR   STRING; 118797.A0A340X6T6; -.
DR   GeneID; 103086550; -.
DR   KEGG; lve:103086550; -.
DR   CTD; 3672; -.
DR   InParanoid; A0A340X6T6; -.
DR   OrthoDB; 3816176at2759; -.
DR   Proteomes; UP000265300; Unplaced.
DR   GO; GO:0009986; C:cell surface; IEA:UniProt.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR   Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR   Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR   Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR   Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR   Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR018184; Integrin_alpha_C_CS.
DR   InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR   InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR   InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR   PANTHER; PTHR23220:SF22; INTEGRIN ALPHA-1; 1.
DR   Pfam; PF01839; FG-GAP; 2.
DR   Pfam; PF08441; Integrin_A_Ig_1; 1.
DR   Pfam; PF20805; Integrin_A_Ig_2; 1.
DR   Pfam; PF20806; Integrin_A_Ig_3; 1.
DR   Pfam; PF00092; VWA; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   PRINTS; PR00453; VWFADOMAIN.
DR   SMART; SM00191; Int_alpha; 5.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR   SUPFAM; SSF69179; Integrin domains; 3.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51470; FG_GAP; 4.
DR   PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003762};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003762};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU003762}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   CHAIN           25..1179
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT                   /id="PRO_5016193692"
FT   TRANSMEM        1142..1169
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   REPEAT          30..91
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   DOMAIN          172..355
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REPEAT          475..537
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          556..614
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          618..678
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ   SEQUENCE   1179 AA;  130636 MW;  CF3CDA8FA884254A CRC64;
     MDPRRRASPG VAVACCWLLT VVLGFCISFN VDVKNSLTFS GPVEDMFGYT VQQYENEEGK
     WVLIGSPLVG QPKNRTGDVY KCPVGRGESL PCIKLDLPVN TSIPNVTEVK ENMTFGSTLV
     TNPNGGFLAC GPLYAYRCGH LHYTTGICSD VSPTFQVVNS IAPVQECSTQ LDIVIVLDGS
     NSIYPWESVT AFLNDLLERM DIGPKQTQVG IVQYGENVTH EFNLNKYSST EEVLVAANKI
     VQRGGRQTMT ALGIDTARKE AFTEARGARR GVKKVMVIVT DGESHDNHQL KKVIQDCDDE
     SIQRFSIAIL GSYNRGNLSA EKFVEEIKSI ASEPTEKHFF NVSDELALVT IVEALGERIF
     ALEATADQSA ASFEMEMSQT GFSAHYSQDW VMLGAVGAYD WNGTVVMQKA NQILIPQNTT
     FNVESTKKNE PLASYLGYTV NSATVSGDVL YIAGQPRYNH TGQVVIYRME DGVIRILQTL
     HGEQIGSYFG SVLTTVDIDK DSNTDILLVG APMFMGTEKE EQGKVYIYAL NQTRFEYQMS
     LEPMKQTCCS SLKHNSCTKE NRNEPCGARF GTAISAVKDL NLDGFNDIVI GAPLEDDHGG
     AVYIYHGSGK TIREEYAQRI PSGGDGETLK FFGQSIHGEM DLNGDGLTDV TIGGLGGAAL
     FWSRDVAVVK VTMNFEPNKV NIQKKNCRVE GKETVCINAT VCFDVKLKSK EDRVYEADMQ
     YRITLDSLRQ ISRSFFSGTQ ERKIQRNITV RESECTKHSF YMLDKHDFRD SVRITLDFNL
     TDPENGPVLD DSLPNSVHEY IPFAKDCGNK EKCISDLALD VSTTEKGLLI VRSHNDKFNV
     SLTVKNKEDS AYNTRTIVNY SPNLIFSGIE AIQKDSCESN HNITCKVGYP FLRRGEMVTF
     KILFQFNSSY LMENVIIHLS TTSDSEEPPE AVFDNEVNVS IPVKYEVGLQ FYSSASEYHI
     SIAANETVPE VISSTEDIGN EINIFYLIRK SGHFPMPELK LSISFPNMTS DGFPVLYSSG
     WSSSENVNCR PSSLQDPFGI NSGKKIIISK SEDIKRGAIL DCSACKFATI TCNLIPSDMS
     QVNVSLILWK PTFIKAHFSS LNLTVGAELQ SENTSLVLSA GNQKRELAIQ ISKDGLPGRV
     PLWVILLSAF AGLLLLMLLI LALWKIGFFK RPLKKKMEK
//

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