ID   A0A340X717_LIPVE        Unreviewed;       490 AA.
AC   A0A340X717;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Heat shock factor protein 4 isoform X1 {ECO:0000313|RefSeq:XP_007457358.1};
GN   Name=HSF4 {ECO:0000313|RefSeq:XP_007457358.1};
OS   Lipotes vexillifer (Yangtze river dolphin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Lipotidae; Lipotes.
OX   NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007457358.1};
RN   [1] {ECO:0000313|RefSeq:XP_007457358.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the HSF family. {ECO:0000256|ARBA:ARBA00006403,
CC       ECO:0000256|RuleBase:RU004020}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_007457358.1; XM_007457296.1.
DR   AlphaFoldDB; A0A340X717; -.
DR   STRING; 118797.A0A340X717; -.
DR   GeneID; 103069379; -.
DR   KEGG; lve:103069379; -.
DR   CTD; 3299; -.
DR   InParanoid; A0A340X717; -.
DR   OrthoDB; 1117127at2759; -.
DR   Proteomes; UP000265300; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000232; HSF_DNA-bd.
DR   InterPro; IPR027725; HSF_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10015:SF213; HEAT SHOCK FACTOR PROTEIN 4; 1.
DR   PANTHER; PTHR10015; HEAT SHOCK TRANSCRIPTION FACTOR; 1.
DR   Pfam; PF00447; HSF_DNA-bind; 1.
DR   PRINTS; PR00056; HSFDOMAIN.
DR   SMART; SM00415; HSF; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00434; HSF_DOMAIN; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW   Stress response {ECO:0000313|RefSeq:XP_007457358.1}.
FT   DOMAIN          59..83
FT                   /note="HSF-type DNA-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00434"
FT   REGION          248..284
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          336..394
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        353..367
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   490 AA;  52618 MW;  CE7AC2A9DDAACC5D CRC64;
     MQEAPAALPT EPGPSPVPAF LGKLWALVGD AGTDHLIRWS PSGTSFLVSD QSRFAKEVLP
     QYFKHSNMAS FVRQLNMYGF RKVVSIEQGG LLRPERDHVE FQHPSFVRGR EQLLERVRRK
     VPALRGDDGR WRPEDLGRLL GEVQAFRGVQ ESTEARLREI RQQNEILWRE VVTLRQSHGQ
     QHRVIGKLIQ CLFGPLQAGS SSAGTKRKLS LMLDEGCPTP AKFNACPLPG ALLQDPCFIQ
     SPLPETTLGL SSPHRARGPI ISDIPEDSPS PEGTRLSPSS GGRREKGLAL LKEEPASPGG
     EGEAGLALAP NECDFCVTAP PPLPVAVVQA ILEGKGSLSP EGPRSAQQPE PRGPREVPDR
     GPLDLERGAR SPESLLPPML LRAPPESVEP AGPLDVLGTS LQGREWTLMD LDMELSLLQP
     LVPEKGETEL AVKGLNSPGP GKDSMLGAPL LLDVQAALGG PALSLPGALT IYSAPESRAS
     YLGPGANPSP
//