ID A0A340X8Q1_LIPVE Unreviewed; 329 AA.
AC A0A340X8Q1;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Toll-like receptor {ECO:0000256|RuleBase:RU363040};
GN Name=LOC103075072 {ECO:0000313|RefSeq:XP_007455415.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007455415.1};
RN [1] {ECO:0000313|RefSeq:XP_007455415.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU363040}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU363040}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|RuleBase:RU363040}.
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DR RefSeq; XP_007455415.1; XM_007455353.1.
DR AlphaFoldDB; A0A340X8Q1; -.
DR STRING; 118797.A0A340X8Q1; -.
DR GeneID; 103075072; -.
DR KEGG; lve:103075072; -.
DR InParanoid; A0A340X8Q1; -.
DR OrthoDB; 21383at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF422; TOLL-LIKE RECEPTOR 6; 1.
DR Pfam; PF01463; LRRCT; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|RuleBase:RU363040};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|RuleBase:RU363040};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|RuleBase:RU363040}; Membrane {ECO:0000256|RuleBase:RU363040};
KW Receptor {ECO:0000256|RuleBase:RU363040,
KW ECO:0000313|RefSeq:XP_007455415.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|RuleBase:RU363040};
KW Transmembrane helix {ECO:0000256|RuleBase:RU363040}.
FT TRANSMEM 147..171
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363040"
FT DOMAIN 202..329
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_007455415.1"
FT NON_TER 329
FT /evidence="ECO:0000313|RefSeq:XP_007455415.1"
SQ SEQUENCE 329 AA; 37658 MW; 55D06AB7DB113FC1 CRC64;
ILTDSVFRCL PPRVKVLDLH NNRIRSIPKD VTSLETLQEL NVASNSLAHL PGCGTFGSLS
ILIIDYNSVS NPSADFFQSC QKIRSLRAGN NPFQCTCELR DFIQSVGQVS SEVVEGWPDS
YKCDYPESYK GTPLKDFHVS QLSCNTALLI VTIGVPGLVL AVTVTVLCIY LDLPWYLRMV
CQWTQTRRRA RDVPLGELQR ALQFHAFISY SERDSAWVKN ELIPNLEKED IRICLHERNF
VPGKSIVENI INCIEKSYKS IFVLSPNFVQ SEWCHYELYF AHHNLFHEGS NNLILILLEP
IPQNSIPGKY HKLRALMAQR TYLEWPKEK
//
