ID A0A340X9V3_LIPVE Unreviewed; 2773 AA.
AC A0A340X9V3;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Nucleosome-remodeling factor subunit BPTF isoform X1 {ECO:0000313|RefSeq:XP_007456847.1};
GN Name=BPTF {ECO:0000313|RefSeq:XP_007456847.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007456847.1};
RN [1] {ECO:0000313|RefSeq:XP_007456847.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007456847.1; XM_007456785.1.
DR STRING; 118797.A0A340X9V3; -.
DR GeneID; 103081774; -.
DR KEGG; lve:103081774; -.
DR CTD; 2186; -.
DR InParanoid; A0A340X9V3; -.
DR OrthoDB; 2878869at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0016589; C:NURF complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd05509; Bromo_gcn5_like; 1.
DR CDD; cd15559; PHD1_BPTF; 1.
DR CDD; cd15560; PHD2_3_BPTF; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR038028; BPTF.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45975; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR PANTHER; PTHR45975:SF2; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF00628; PHD; 2.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS01359; ZF_PHD_1; 2.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 103..163
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 253..300
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2594..2645
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2671..2741
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1105..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1247..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1366..1439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1711..1740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1969..2006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2083..2283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2443..2463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2512..2585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1760..1787
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2349..2379
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..50
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..885
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..1019
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1026..1064
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1105..1120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1247..1263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1370..1392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1406..1436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2083..2136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2137..2151
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2152..2278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2443..2459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2525..2546
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2561..2585
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2773 AA; 309281 MW; D8CA9E5556B374E3 CRC64;
MVSEEEEEEE DGEAEETQDS EDDEEDEMEE DDDDSDYPEE MEDDDDDDAS YCTESSFRSH
STYSSTPGRR KPRVHRPRSP ILEEKDIPPL EFPKSSEDLM VPNEHIMNVI AIYEVLRNFG
TVLRLSPFRF EDFCAALVSQ EQCTLMAEMH VVLLKAVLRE EDTSNTTFGP ADLKDSVNST
LYFIDGMTWP EVLRVYCESD KEYHHVLPYQ EAEDYPYGPV ENKIKVLQFL VDQFLTTNIA
REELMSEGVI QYDDHCRVCH KLGDLLCCET CSAVYHLECV KPPLEEVPED EWQCEVCVAH
KVPGVTDCVA EIQKNKPYIR HEPIGYDRSR RKYWFLNRRL IIEEDTENEN EKKIWYYSTK
VQLAELIDCL DKDYWEAELC KILEEMREEI HRHMDITEDL TNKARGSNKS FLAAANEEIL
ESIRAKKGDI DIVKSPEEIE KEKNETENNN SKDAEKSREE FEDQSLEKDS DDKTPDDPEQ
GKSEVGDFKS EKSNGEISES PGGGRGASGS TRIITRLRNP DSKLSQLKSQ QVAAAAHEAN
KLFKEGKEVL VVNSQGEISR LSTKKEVVMK GNINNYFKLG QEGKYRVYHN QYSTNSFALN
KHQHREDHDK RRHLAHKFCL TPAGEFKWNG SVHGSKVLTI STLRLTITQL ENNIPSSFLH
PNWASHRANW IKAVQMCSKP REFALALAIL ECAVKPVVML PIWRESLGHT RLHRMTSIER
EEKEKVKKKE KKQEEEETMQ QATWVKYTFP VKHQVWKQKG EEYRVTGYGG WSWISKTHVY
RFVPKLPGNT NVNYRKSLEE TKSNMDENMD ESDRRKNPRS PKKIKTESDS EKGEVKDSDT
TKGADQSDMD ISKVTEKKDQ DVKEVLDSDN DKSFKEEPME IDDDVKTESH INCQESSQVD
VVNVSEGFHL RTSYKKKIKS SKLDGLLERR IKQFTLEEKQ RHEKMKLEGG IKGIGKTCTS
SSKSLSESPV ITKVKEGCQS DLLTQEQSPN ASNDKSEDLI RGCSQNDSSV LGISDPDHTT
NKLYSKDQML DDASIQSSET NRQKQNSVRN DINASLSDPA SKGQEPSKIK TKGSDFLIDD
AKLASADEIG TLIYKNKKPL MQEDNDTIVS PSQSPLLPSV PKSTDERDIP SLSKAIDFEG
KLGCDSEYNS TLENSSDTMS IQDSSEEDMI VQNSNESISE QLITQEQGSE GLEPLKHEFV
SDKTTGNCGD RLQAKVNEAN GKKTSQDQKL EERPLNKCID QINLKSVTDK KNNENRESEK
KGQKASTFQI NGKDNKPNIY LKGECLKDIS ESKVGSCDIE PKVNNINKII PENDIKSLTV
KESAVKPFMN GDVIMEDFNE KNNLETKSCL LRSSDTEGDY QDRLETLPST KESEGTQATT
PLPSCPESSS ANQEEDMEIE TCEVKKVTSS PVTSGEDSNF SNDFIDENGP PTNKDENVNG
ESKRKTIITE VTTMTSTVAT ESKTVIKVAK VDKQTVVSST ENCAKSTVTT TTTTVTKLST
PSTGSSVDII SVKEQSKTVV TTTVTDSLTT AGGTLVTSMT VSKEYSTRDK VKLMKFSRPK
KARSGTALPS YRKFITKSSK KSIFVLPNDD LKKLARKGGI REVPYFNYNA KPALDIWPYP
SPRPTFGITW RYRLQTVKSL AGVSLMLRLL WASLRWDDMA AKAPPGGGTT RTETSETEIT
TTEIIKRRDV GPYGIRSEYC IRKIICPIGV PEAPKETPTP QRKGLRSSAL RPKRPETPKQ
TGPVIIETWV AEEELELWEI RAFAERVEKE KAQAVEQQAK KRLEQQKPTV IAASTTSPAN
STTSTISPAQ KVMVAPISGS VTTGTKMVLT TKVGSPATVT FQQNKNFHQT FATWVKQGQS
NSGVVQVQQK VLGIIPSSTG TSQQTFTSFQ PRAATVTIRP NTSSSGGTAS TSQVITGPQI
RPGMTVIRTP LQQSTLGKAI IRTPVMVQPG TPQQVVTQII RGQPVSTAIS APSTVSSTPA
QKGLTSGAPT ASLQPSASQP PRPQQGQVKL TMAQLTQLTQ GHGGNQGLTV VIQGQGQTTG
QLQLIPQGVT ILPGPGQQLM QAAMPNGTVQ RFLFTPLATT ATATSTTTTT VSTTAAGTSE
QRQSKLSPLT QVQPAKSLPP AQPSSVSPAE AQPQTAQPAQ PQPPTQPPSP AQPEAQTQAT
SASHVPPEAQ PTQAQSSKPQ GAGQCQPQSN VQGQSPARVQ SPPQTRMRPS TPSQVSPGQQ
SQGQTTASQP IPIQPHTSLQ PPSQGQPQSQ PQVQSSTQTL SSGQTLSQVT VSSPSRPPLQ
VRQPQPQVLA VPQLQQVQVL SQIQSQVVAQ IQAQQGGVPQ QIKLQVPVQM QQSSPVQTHQ
IQNVVTVQAA SVQEQLQRVQ QLRDQQQKKK QQQIEIKREH TLQASNQSEI IQKQVVMKHN
AVIEHLKQKK TMTPAEREEN QRMIVCNQVM KYILDKIDKE EKQAAKKRKR EESVEQKRSK
QNASKLSALL FKHKEQLKAE ILKKRALLDK DLQIEVQEEL KRDLKIKKEK DMMQATAVAA
TSPAAAPAPP APPPSPPPPP PPQHSGPLAT ATATATLPVA SQKRKREEER DSSSKSKKKK
MISTTSKETK KDTKLYCICK TPYDESKFYI GCDRCQNWYH GRCVGILQSE AELIDEYVCP
QCQSTEDAMT VLTPLTEKDY EGLKRVLRSL QAHKMAWPFL EPVDPNDAPD YYGVIKEPMD
LATMEERVQR RYYEKLTEFV ADMTKIFDNC RYYNPSDSPF YQCAEVLESF FVQKLKGFKA
SRSHNNKLQS TAS
//
