ID A0A340X9X9_LIPVE Unreviewed; 423 AA.
AC A0A340X9X9;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Lysosomal acid phosphatase {ECO:0000256|ARBA:ARBA00039422};
DE EC=3.1.3.2 {ECO:0000256|ARBA:ARBA00012646};
GN Name=ACP2 {ECO:0000313|RefSeq:XP_007455810.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007455810.1};
RN [1] {ECO:0000313|RefSeq:XP_007455810.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome lumen {ECO:0000256|ARBA:ARBA00004227}.
CC Lysosome membrane {ECO:0000256|ARBA:ARBA00037852}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00037852}; Lumenal side
CC {ECO:0000256|ARBA:ARBA00037852}.
CC -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC {ECO:0000256|ARBA:ARBA00005375}.
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DR RefSeq; XP_007455810.1; XM_007455748.1.
DR AlphaFoldDB; A0A340X9X9; -.
DR STRING; 118797.A0A340X9X9; -.
DR GeneID; 103077813; -.
DR KEGG; lve:103077813; -.
DR CTD; 53; -.
DR InParanoid; A0A340X9X9; -.
DR OrthoDB; 5489935at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR CDD; cd07061; HP_HAP_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR033379; Acid_Pase_AS.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR11567:SF180; LYSOSOMAL ACID PHOSPHATASE; 1.
DR Pfam; PF00328; His_Phos_2; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00616; HIS_ACID_PHOSPHAT_1; 1.
DR PROSITE; PS00778; HIS_ACID_PHOSPHAT_2; 1.
PE 3: Inferred from homology;
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..423
FT /note="Lysosomal acid phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016438288"
FT TRANSMEM 381..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 423 AA; 48726 MW; 7A2EF7FAA2BB833F CRC64;
MAGRQFGWSR VALLQLFLGV NLMVMPPTQA RRLRFVTLLY RHGDRSPVKT YPKDPYQEDE
WPQGFGQLTK EGMLQHWELG QALRQRYHDF LNTSYHRQEV YVRSTDFDRT LMSAEANLAG
LFPPDRMQHF NPNISWQPIP VHTVPIAEDR LLKFPLGPCP RFEQLQNETR RTPEYQNESI
QNAQFLDMVA NETGLTDLTL ETIWNVYDTL FCEQTHGLVL PPWASPQTMQ RLSRLKDFSF
RFLFGIYEQA EKARLQGGVL LAQIRKNLTL MATTSQLPKL LVYSAHDTTL VALQMALDVY
NGEQAPYASC HIFELYQEDT GNFSVEMYFR NESNKAPWPL ILPGCPHRCP LQDFLRLTEP
VVPKDWQQEC RLASSPADTE VIVALAVCGS ILFLLIVLLL TVLFRMQAQP PGYRHVPDGE
DHA
//
