ID A0A340XAY2_LIPVE Unreviewed; 383 AA.
AC A0A340XAY2;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=NIPA-like protein 2 {ECO:0000313|RefSeq:XP_007457222.1};
GN Name=NIPAL2 {ECO:0000313|RefSeq:XP_007457222.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007457222.1};
RN [1] {ECO:0000313|RefSeq:XP_007457222.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NIPA family.
CC {ECO:0000256|ARBA:ARBA00007230}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007457222.1; XM_007457160.1.
DR AlphaFoldDB; A0A340XAY2; -.
DR STRING; 118797.A0A340XAY2; -.
DR GeneID; 103071754; -.
DR KEGG; lve:103071754; -.
DR CTD; 79815; -.
DR InParanoid; A0A340XAY2; -.
DR OrthoDB; 2906343at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR008521; Mg_trans_NIPA.
DR PANTHER; PTHR12570:SF16; NIPA-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR12570; UNCHARACTERIZED; 1.
DR Pfam; PF05653; Mg_trans_NIPA; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 46..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 351..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 383 AA; 41822 MW; 5E1D962521E66291 CRC64;
MAAPAPRGPG AAASAALDEL SRNLTYGALG AGNGSLSGAW YRRNQIHLFG VLLAILGNLV
ISISLNIQKY SHLQLAHQEH PRPYFKGMLW WGGVILMAVG ETGNFAAYGF APITLIAPLG
CMSVTGSAII SVMFLKENLR ASDLLGMTLA FAGTYLLVNF APNITQDISA RTVQYYFVGW
QFMTYGILEI LIFCILLYFH KRKGMKHIVI LLTLVALLAS LTVISVKAVS GMIAFSVMDK
MQLTYPIFYI MFVIMIASCV FQVKLLNQAT KLYNTATVVP MNHTFFTISA IIAGIIFYKE
FLGAAFLTIF IYLFGCVLSF LGVVLVTRNR GKEHLPQSYV DIGHVPGKQT LDKIQPDSNG
LSYGTLPDGS DSTKSPSGEK KEV
//
