ID A0A340XEK6_LIPVE Unreviewed; 2490 AA.
AC A0A340XEK6;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Cation-independent mannose-6-phosphate receptor {ECO:0000313|RefSeq:XP_007457644.1};
GN Name=IGF2R {ECO:0000313|RefSeq:XP_007457644.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007457644.1};
RN [1] {ECO:0000313|RefSeq:XP_007457644.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00479}.
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DR RefSeq; XP_007457644.1; XM_007457582.1.
DR STRING; 118797.A0A340XEK6; -.
DR GeneID; 103074704; -.
DR KEGG; lve:103074704; -.
DR CTD; 3482; -.
DR InParanoid; A0A340XEK6; -.
DR OrthoDB; 2910338at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005537; F:mannose binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0007041; P:lysosomal transport; IEA:InterPro.
DR CDD; cd00062; FN2; 1.
DR Gene3D; 2.10.10.10; Fibronectin, type II, collagen-binding; 1.
DR Gene3D; 2.70.130.10; Mannose-6-phosphate receptor binding domain; 15.
DR InterPro; IPR000479; CIMR_rpt.
DR InterPro; IPR000562; FN_type2_dom.
DR InterPro; IPR036943; FN_type2_sf.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR009011; Man6P_isomerase_rcpt-bd_dom_sf.
DR InterPro; IPR044865; MRH_dom.
DR PANTHER; PTHR15071:SF0; CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR15071; MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER; 1.
DR Pfam; PF00878; CIMR; 15.
DR Pfam; PF00040; fn2; 1.
DR PRINTS; PR00013; FNTYPEII.
DR SMART; SM01404; CIMR; 14.
DR SMART; SM00059; FN2; 1.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR SUPFAM; SSF50911; Mannose 6-phosphate receptor domain; 15.
DR PROSITE; PS00023; FN2_1; 1.
DR PROSITE; PS51092; FN2_2; 1.
DR PROSITE; PS51914; MRH; 15.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_007457644.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..39
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 40..2490
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016287184"
FT TRANSMEM 2308..2329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 47..163
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 172..320
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 326..471
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 476..621
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 627..764
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 767..926
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 934..1082
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 1085..1222
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 1228..1366
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 1370..1511
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 1517..1651
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 1653..1800
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 1805..1992
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 1901..1947
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 1995..2130
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT DOMAIN 2138..2283
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT REGION 2427..2490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2442..2461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2475..2490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2490 AA; 272910 MW; 606C34F9C064FDF8 CRC64;
MGAAAGRSAH LGPAPAGRPP RSVLLLQLLL LVWAPGAAGT QGAEFPELCS YTWEAVDTRN
NMLYKINICG NVNIAQCGTS SAVCMHDLKT DNFHSVGDSH LKNATRSLLE FNTAVSCGQQ
STNHRIQSSI TFLCGKTLGT PEFVTATDCV HYFEWRTTAA CKKDVFKANK EVPCYVFDRE
LKKHDLNPLI KISGAYLVDD SDVDTSLFIN VCRDIEVLRA TSPEVRSCPT GTAACLVRGD
RAFDVGRPKE GLKLMSNDRL VLSYVKEGAV HPDFCEGHSP AVTITFVCPS ERRAGTLPKL
TAKSNCRFEI EWITEYACHR DYLESGNCSL SSEQHDIAID LQPLSQLGAS NSSYYTAEGE
EYVFYLNVCG GTEAHICDKK DAAVCQMKKS DSTQVKVAGK LQSQTLRYSD GDLTLVYFGG
DTCSSGFQRM SVINFACNQT AGNNGRGAPV FTGEVDCSYF FTWDTKYACV GEKEALLCGV
SDGMQRFDLS ALARHSELEQ NWEAVDGSQR EPEKKHFFIN ICHRVLQKGR ARGCPEDAAV
CAVDKDGSKN LGRFLSSPTR EKGHIQLSYS DGDECGDTKI STNITLVCKP GDLESAPVLR
TSAADGCFYE FEWYTAAACV LSRTEGDNCT VFDSQAGFSF DLSPLTKKSG AYKVETEKYE
FYINVCGAVS VGSCQLDSGA CQVSKSGGKS WSLGRSNAKL SYYDGMIQLN YKDGTSYNNE
RHTPRATLLT FLCDRDAGVG LPEYQEEDNS TYNFRWYSSY ACPAEPLECV VTDPSTMEQY
DLSSLAKSEA GPGGNWFALD SAGAHSAWRK YYINVCRPLS PVPGCDRSAS ACQMAYQSDR
GSFSETVSIS NLGMAKTGPM VEDSGSLLLE YVNGSACTTS DGRRTTYTTR IHLVCSRGSL
NTHPIFSLSW ECVVSFLWNT EAACPVQVTT DTDQACSIRD PNSGYVFDLN PLNSSQGYVV
SGIGKTFVFN VCGAMPVCGT LDGKPASGCE AETQTEELKN LKPGRLVGLE KSLQLSTEGF
ITLTYTGLPS HPRGRADAFI IRFICNDDVY PGTPRFLHRD IDSDLGIRDT FFEFETALAC
VPSPVDCQVM DLAGNEYDLS GLSKVKKPWT AVDTSADGKR RTFYLSVCNP LPYIPGCHGS
AVGSCLVSED NGWNLGVVQV SPQVAANGSL SIVYVNGDKC GNQRFSTRIT LECAHTTGSP
TFQLLDDCEY VFVWRTVEAC PVVRVEGDNC EVRDPRHGNM YDLKPLGLND TVVRAGEYTY
YFRVCGKLSS GVCSTDDKSK VISSCQAKRG PQGFQKVAGL LTQKLIYENG VLKMNYTGGD
TCHKVYRRST TIIFYCDRST QAPVFLQETS DCSYLFEWHT QYACPPFDLT ECSFKDGAGN
TFDLSSLSRY SDNWEAVTRT GATEHYLINV CKSLAPQAGS EPCPPEAAVC LLGGSKPVNL
GRVRDGPQGS EGMTLLRYVD GDLCPDQIRK KSTTIRFSCS ESQVNSRPMF LSAVEDCEYT
FSWPTAAACP VKSNVHDDCQ VTNPSTGHLF DLSSLSGRTG YTAAYSEKGL VYLSVCGDNE
NCAPGVGACF GQTRISVGKA NKRLKYVDQV LQLVYEDGSP CPSKTGLSYK SVISFVCRPE
AGPTNRPMLI SLDKQTCTLF FYWHTPLACE QVTECFVRNG SSIIDLSPLI HRTGGYEAYD
ESEDDASDTN PDFYINICQP LNPMHGVPCP AGTAVCKVPI DGTPVDIGRV TGPPILNPIA
NEVYLNFESS TPCLVNKHFN YTSLIAFHCK RGVSMGTPKL LRTSDCDFVF EWETPLVCPD
EVKAEGCSLT DEQLHYSFNL SSLSKSTFKV TRDSRTYSVG VCTAAAGLDQ GGCKDGSVCL
LSGSKGVSFG RLASMRLDYR HQDEAVILSY ANGDNCPPET EGGAPCVFPF VFNGKSYEEC
VLEGRARLWC ATTANYDRDH EWGFCRHSNS HRTSAIIFKC DEDADVGRPQ VFSEIRGCEV
TFEWKTKVIC PPKKMECKFI QKHKTYDLRL LSSLTGSWFF VHDGTSYYVN LCQKIYKGPL
DCSERASVCR KSPSGDVQVL GLVHTQKLDV IDDRVIVTYS KGYQCGDNKT ASAVIELTCA
KTVGRPSFTR FDMDSCTYHF SWDSRAACAV KPQEVQMVNG TITNPANGRS FSLGDIYFKR
FSASGDMRTN GDKYLYEIQL SSITSSTNPA CSGANICQVK PNDQHFSRKV GTSDKTKYYV
QDGDLDVVFA SSSKCGKDKT KSVSSTIFFH CDPLVKDGIP EFSHETADCQ YLFSWYTSAV
CPLGVGLDSE SAGDDAQEHK GLSERSQAVG AVLSLLLVAL TGCLLALLLH KKERRETVMS
KLTSCCRRSA DVSYKYSKVN KEEEADENET EWLMEEIQLP SPRPGKEGQE NGHITTKSVK
AEALTSLHGD DQDSEDEVLT IPEVKVHLGR GTGAEGVHPL RPPPRKALRE RADDRVGLMS
GEQARKGRPR AAQKTVSSFH DDSDEDLLHI
//
