ID A0A340XJJ6_LIPVE Unreviewed; 1105 AA.
AC A0A340XJJ6;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A5 {ECO:0000313|RefSeq:XP_007459459.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007459459.1};
RN [1] {ECO:0000313|RefSeq:XP_007459459.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR RefSeq; XP_007459459.1; XM_007459397.1.
DR AlphaFoldDB; A0A340XJJ6; -.
DR STRING; 118797.A0A340XJJ6; -.
DR GeneID; 103080314; -.
DR KEGG; lve:103080314; -.
DR CTD; 57835; -.
DR InParanoid; A0A340XJJ6; -.
DR OrthoDB; 1013180at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF20; ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 4; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 508..530
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 542..573
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 593..614
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 626..649
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 729..747
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 767..786
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 815..833
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 853..869
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 915..935
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 941..960
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1010..1027
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 135..402
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 479..993
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1049..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1049..1067
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1105 AA; 123240 MW; 35DF175A7F56B044 CRC64;
MKVEEEKAEV GKLDPPNYRR RCQDQEDCRS IHIGLSVPSY PHRKRDPKGH LSGLQKVRWG
LRPDKPQQGL ASACSTMDHV IRTRSPAAEQ LQDILGEEDE APNPTLFTEM DTLQHDGDQM
EWKESARWIK FEEKVEEGGE RWSKPHVSTL SLHSLFELRT CLQTGTVLLD LDSGSLPQII
DDVIEKQIED GLLRPELRER VSYVLLRKHR HQTKKPIHRS LVDIGKSVSS TTNRSPGRSP
AAGPSLHHST EDLRMRQSAN YGRLCHAQSR SMNDISVTPN TDQRKNKFMK KIPKDSEASN
VLVGEVDFLD QPFIAFVRLI QSAMLGGVTE VPVPTRFLFI LLGPSGRAKS YNEIGRAIAT
LMVDDLFSDV AYKARNREDL IAGIDEFLDE VIVLPPGEWD PNIRIEPPKK VTSADKRKSV
FSLTELGQMN GSVTGSGGGA GGGGAAGGGG SGAGGGSSGD DGEMPTVHEI GEELIWTGRF
FGGLCLDVKR KLPWFPSDFY DGFHIQSISA ILFIYLGCIT NAITFGGLLG DATDNYQGVM
ESFLGTAMAG SLFCLFSGQP LIILSSTGPI LIFEKLLFDF SKGNGLDYME FRLWIGLHSA
VQCLILVATD ASFIIKYITR FTEEGFSTLI SFIFIYDAIK KMIGAFKYYP INMNFKPDSI
TIYKCECVAP DTANTTAFNA SATSPPNTNT SLYNPLNLTA LDWSLLSKKE CLNYGGRLLG
NSCQFIPDLA LMSFILFFGT YSMTLTLKKF KFSRYFPTKV RALVADFSII FSILLFCGID
ACFGLATPKL LVPSVIKPTR PDRGWFVAPF GKNPWWVYLV SILPALLVTI LIFMDQQITA
VIVNRKENKL RKAAGYHLDL FWVGILMALC SFMGLPWYVA ATVISIAHID SLKMETETSA
PGEQPQFLGV REQRVTGTIV FILTGISVFL APILQYIPLP VLYGVFLYMG VASLNGIQFW
DRCKLFLMPA KHQPDHAFLR HVPLRRIHLF TLVQILCLAV LWILKSTMAA IIFPVMILGL
IIVRRLLDLI FSQHDLAWID NILPEKEKKE ADKKKRKGAH EHSDEEPQFP PPSVIKIPME
SVQSDPKNCI HCVARQRPSS WSHSL
//
