ID A0A340XJR1_LIPVE Unreviewed; 1349 AA.
AC A0A340XJR1;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Cullin-associated NEDD8-dissociated protein 2 {ECO:0000313|RefSeq:XP_007461641.1};
GN Name=CAND2 {ECO:0000313|RefSeq:XP_007461641.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007461641.1};
RN [1] {ECO:0000313|RefSeq:XP_007461641.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CAND family.
CC {ECO:0000256|ARBA:ARBA00007657}.
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DR RefSeq; XP_007461641.1; XM_007461579.1.
DR STRING; 118797.A0A340XJR1; -.
DR GeneID; 103070302; -.
DR KEGG; lve:103070302; -.
DR CTD; 23066; -.
DR InParanoid; A0A340XJR1; -.
DR OrthoDB; 68829at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0010265; P:SCF complex assembly; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039852; CAND1/CAND2.
DR InterPro; IPR013932; TATA-bd_TIP120.
DR PANTHER; PTHR12696:SF2; CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 2; 1.
DR PANTHER; PTHR12696; TIP120; 1.
DR Pfam; PF08623; TIP120; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1158..1320
FT /note="TATA-binding protein interacting (TIP20)"
FT /evidence="ECO:0000259|Pfam:PF08623"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..37
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..457
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1349 AA; 146864 MW; 67C21BC352659484 CRC64;
MGRLQGWRRA ETTELLAGPS RQPPPANRLP PPAAAAKAEP PSLLLAAGST PAPETPPPRL
CARRKPGLSS PRIACPVLSG TPAQLRLPPC KLQPLAAEWC SMLLRQPQLS VTFQLRLHCN
FKCRGQGIRP HGSAQLFMAT SDLMSELQKD SIQLDEDSER KVVKMLLRLL EDKNGEVQNL
AVKCLGPLVG KVKEYQVETI VDALCANMRS DKEQLRDIAG IGLKTVLSEL PPAATGSGLA
TSVCRKITGQ LTSAIAQQED AAVQLEALDI LSDMLSRLGA PLGAFHASLL HCLLPQLSSP
RLAVRKRAVG ALGHLAAACS TDLFVELADH LLDRLPGPRA PASPAAIRTL IQCLGSVGRQ
AGHRLGTHLD RLVPLVEEFC KLDDDELRES CLQAFEAFLR KCPKEMGPHV PSVTSLCLQY
IKHDPNYNCD SDEEEEKMET EDSEFSEQQS EDEYSDDDDM SWKVRRAAAK CLVALISSRP
DLLTNFHCTL APVLIRRFRE REENVKADVF GAYIVLLRQT RSLKGWLEAV EEPTQSGSNL
QMLRGQVPLV MKALQRQLKD RSVRARQGCF SLLTELAGIL PGSLAEHMPV LVAGIIFSLA
DRSSSSTIRM DALAFLQGLL GTEPAEAFHP QLPTLLPPVM ACVADPFYKI AAEALLVLQE
LVRALWPLDR PRVLDPEPYI GEMSAATLAR LRATDLDQEV KERAISCVGH LVGHLGDRLG
DNLEPSLLLL LDRLRNEITR LSAVKALTLV AVSPLRIDLQ PILAEALPIL ASFLRKNQRA
LRLAALAALA ALAQSQGLGL PPSTVRAVLA ELPSLVSEND MHVAQLAVDF LATVTRAQPA
SLAEVSGPVL AELLRLLHSP LLPAGVLAAA EGFLQALVGT RPPCVDYAEL VGLLTAPVYE
QVADGGPGLH KQVFHSLARC VAALAVACPQ EVVDTVNRLV SDARSPSSSP GVKVLAFLSL
AEVGQVAGPG PQRELKAVLL EALGSPSEDV RAAASYALGR VGAGNLPDFL PFLLGQMEAE
PRRRYLLLHS LREALGAAQP DSLKPYAEDV WALLFQRCEG AEEGTRGVVA ECLGKLVLVN
PPFLLPRFRK QLAAGQPHTR CTVITAVKFL ISDQPHPIDP ILKTFVGEFM ESLQDPDLNV
RRATLAFFNS AVHNKPSLVR DLLDDILPLL YQETKIRRDL IREVEMGPFK HTVDDGLDVR
KAAFECMYSL LESCLGQLDI CEFLNHVEDG LKDHYDIRML TFIMLARLAT LCPVPVLQRV
DRLIEPLRAT CTAKVKAGSV KQEFEKQDEL KRSAMRAVAT LLTIPEVGKS PIMADFSSQI
RSNPELAALF ESIQKDSASA PSTDSMELS
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