ID A0A340XJZ9_LIPVE Unreviewed; 560 AA.
AC A0A340XJZ9;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Polypyrimidine tract-binding protein 1 {ECO:0000256|ARBA:ARBA00019540};
GN Name=PTBP1 {ECO:0000313|RefSeq:XP_007460472.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007460472.1};
RN [1] {ECO:0000313|RefSeq:XP_007460472.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_007460472.1; XM_007460410.1.
DR AlphaFoldDB; A0A340XJZ9; -.
DR STRING; 118797.A0A340XJZ9; -.
DR GeneID; 103075088; -.
DR CTD; 5725; -.
DR InParanoid; A0A340XJZ9; -.
DR OrthoDB; 4825346at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd12777; RRM1_PTBP1; 1.
DR CDD; cd12782; RRM2_PTBP1; 1.
DR CDD; cd12695; RRM3_PTBP1; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR006536; HnRNP-L/PTB.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR021790; PTBP1-like_RRM2.
DR InterPro; IPR035000; PTBP1_RRM1.
DR InterPro; IPR035001; PTBP1_RRM3.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01649; hnRNP-L_PTB; 1.
DR PANTHER; PTHR15592; MATRIN 3/NUCLEAR PROTEIN 220-RELATED; 1.
DR PANTHER; PTHR15592:SF19; POLYPYRIMIDINE TRACT-BINDING PROTEIN 1; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF13893; RRM_5; 2.
DR Pfam; PF11835; RRM_8; 1.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 4.
DR PROSITE; PS50102; RRM; 4.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 62..146
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 187..263
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 366..440
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 483..558
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
SQ SEQUENCE 560 AA; 59851 MW; 91787938ECC48AC9 CRC64;
MDGIVPDIAV GTKRGSDELF SACVTNGPFI MSSNSASTGI AANGNDSKKF KGDNRSTGVP
SRVIHIRKLP SDVTEGEVIS LGLPFGKVTN LLMLKGKNQA FIEMNTEEAA NTMVNYYTSV
TPVLRGQPIY IQFSNHKELK TDSSPNQARA QAALQAVNSV QSGNLALAAS AAAVDAGMAM
AGQSPVLRII VENLFYPVTL DVLHQIFSKF GTVLKIITFT KNSQFQALLQ FAEPASAQHA
KLSLDGQNIY NACCTLRIDF SKLTSLNVKY NNDKSRDYTR PDLPSGDSQP SLDQTMAAAF
GAPGIMSASP YAGAGFPPTF AIPQAAGLSV PNVHGALAPL AIPSAAAAAA AAGRIAIPGL
AGAGNAVLLV SNLNPERVTP QSLFILFGVY GDVQRVKILF NKKENALVQM ADGSQAQLAM
SHLNGHKLHG KPVRITLSKH QNVQLPREGQ EDQGLTKDYG NSPLHRFKKP GSKNFQNIFP
PSATLHLSNI PPSISEDDLK ILFSSNGGIV KGFKFFQKDR KMALIQMGSV EEAIQALIDL
HNHDLGENHH LRVSFSKSTI
//
