ID A0A340XKN7_LIPVE Unreviewed; 795 AA.
AC A0A340XKN7;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Volume-regulated anion channel subunit LRRC8E {ECO:0000256|ARBA:ARBA00044118};
DE AltName: Full=Leucine-rich repeat-containing protein 8E {ECO:0000256|ARBA:ARBA00044211};
GN Name=LRRC8E {ECO:0000313|RefSeq:XP_007460672.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007460672.1};
RN [1] {ECO:0000313|RefSeq:XP_007460672.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2',3'-cGAMP(out) = 2',3'-cGAMP(in); Xref=Rhea:RHEA:66320,
CC ChEBI:CHEBI:143093; Evidence={ECO:0000256|ARBA:ARBA00043750};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:66321;
CC Evidence={ECO:0000256|ARBA:ARBA00043750};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:66322;
CC Evidence={ECO:0000256|ARBA:ARBA00043750};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00024167};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324,
CC ChEBI:CHEBI:16382; Evidence={ECO:0000256|ARBA:ARBA00024145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328,
CC ChEBI:CHEBI:507393; Evidence={ECO:0000256|ARBA:ARBA00024158};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Lysosome
CC membrane {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LRRC8 family.
CC {ECO:0000256|ARBA:ARBA00010471}.
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DR RefSeq; XP_007460672.1; XM_007460610.1.
DR AlphaFoldDB; A0A340XKN7; -.
DR STRING; 118797.A0A340XKN7; -.
DR GeneID; 103091222; -.
DR KEGG; lve:103091222; -.
DR CTD; 80131; -.
DR InParanoid; A0A340XKN7; -.
DR OrthoDB; 55205at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021040; LRRC8_Pannexin-like.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF47; VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8E; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF12534; Pannexin_like; 1.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 7.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 3.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..330
FT /note="LRRC8 pannexin-like TM region"
FT /evidence="ECO:0000259|Pfam:PF12534"
SQ SEQUENCE 795 AA; 89977 MW; 44FDAEA77CF770E4 CRC64;
MIPVAEFKQF AEHQPAFKVL KPWWDVLAEY LTVAMLMIGV FGCTLQVTQD KIICLPSHEP
RENLSEAPCQ QLLPRGVSEH VGDLREFSGL RNNLDLQQYS FINQLCYETA LHWYAKYFPY
LVVIHTLNFM VCTSFWFKFP STSSKIEHFI SILGKCFDSP WTTRALSEVS GENHKDPAAA
GRAVVTVAAT AAGPGKAGEG EKEKLLAEPE KVVMEPPAAT LLDKKEGEQA KALFEKVKKF
RVHVEEGDIL YTMYIRQTVL KVCKFLAILV YNLIYVGKIS FLVACRVETS EVTGYASFCC
SHTKAHLFSK LAFCYISFMC VYGITCFYTL CWLFHRPLKE YSFRSVREET GMGDIPDVKN
DFAFMLHLID QYDSLYSKRF AVFLSEVSES RLKQLNLNHE WTSEKLRQKL QRNACGRLEL
ALCMLPGLPD TVFELSEVEA LRLEAICDIT FPPGLSQLVH LQEISLLHSP ARLPFSSQIF
LRDHLKVIRV KCEELREVPL WVFGLRSLEE LHLEGVFPQE LARAATLESL RELKQLKVLS
LRSNAGKVPA SVTDVAGHLQ RLSLHNDGAR LLALNSLKKL AVLRELELVA CGLERIPHAV
FSLGALQELD LKDNHLRSIE EILSFQHCRK LVTLRLWHNQ IAYVPEHVRK LRGLEQLYLS
HNKLETLPTQ LGMCSGLRLL DVSHNGLHSL PAELGLLQNL QHLAVSYNAL ELLPDELFFC
CKLRTLLLGY NNLSQLSPQV GALGALSRLE LKGNRLEALP EELGNCGGLK KSGLLVEDTL
YEGLPAEVRD RMEME
//
