ID A0A340XLX2_LIPVE Unreviewed; 3067 AA.
AC A0A340XLX2;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=MAX gene-associated protein {ECO:0000313|RefSeq:XP_007460264.1};
GN Name=MGA {ECO:0000313|RefSeq:XP_007460264.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007460264.1};
RN [1] {ECO:0000313|RefSeq:XP_007460264.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR RefSeq; XP_007460264.1; XM_007460202.1.
DR STRING; 118797.A0A340XLX2; -.
DR GeneID; 103084894; -.
DR KEGG; lve:103084894; -.
DR CTD; 23269; -.
DR InParanoid; A0A340XLX2; -.
DR OrthoDB; 5323209at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0071339; C:MLL1 complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18911; bHLHzip_MGA; 1.
DR CDD; cd20195; T-box_MGA-like; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR013788; Hemocyanin/hexamerin.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR037935; MAX_gene-associated_bHLHzip.
DR InterPro; IPR032060; MGA_dom.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267:SF32; MAX GENE-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF16059; MGA_dom; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS00210; HEMOCYANIN_2; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 79..260
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT DOMAIN 2425..2476
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 259..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 971..991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1249..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1380..1431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1473..1518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1731..1754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1838..1861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1898..1927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1969..2062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2140..2166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2260..2315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2532..2561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2577..2597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2942..2969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..920
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 971..990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1256..1284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1293..1310
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1311..1328
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1492..1515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1740..1754
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1972..1993
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2008..2022
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2152..2166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2300..2315
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2546..2561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2579..2597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3067 AA; 336132 MW; 1AFC7B5C5371A305 CRC64;
MEEKQQIILA NQDGGTVAGA APTFFVILKQ PGNGKTDQGI LVTNRDACAL ASSVSSPGKS
KGKICLPADC TVGGITVTLD NNSMWNEFYH RSTEMILTKQ GRRMFPYCRY WITGLDSNMK
YILVMDISPV DNHRYKWNGR WWEPSGKAEP HVLGRVFIHP ESPSTGHYWM HQPVSFYKLK
LTNNTLDQEG HIILHSMHRY LPRLHLVPAE KATEVIQLNG PGVHTFTFPQ TEFFAVTAYQ
NIQITQLKID YNPFAKGFRD DGLNSKPQRD GKQKNSSDQE GNSVPSSPGQ RVRLTEGEGS
EIQLTDSDPL LRGHEASCKG LEKPSLNVKR DFLGFMDIDS ALGEVPQLKQ EVSESLIGNN
FEDGSHVTSP LNPNENFNVV IKEEPLDDYE YELGECPEGV TVKQEETDEE TDVYSNSDDD
PILEKQLKRH NKADKLEADH PSSKWLLPNS PSGVAKAKMF KLDAGKMPVV YLEPCAVTKS
TVKISELPDN MLSTSRKDRT SALTELDYLP TYIENSNETG FCLGKESENG LRRHSPDLRV
VQKYPSLKDP QWKYPDISDS INTEKIPDGS KSSVGDSFLG KEDLGRKKTM LKISMASKTV
NANQNAPPNV PGKRGRPRKL KLSKAGRPPK NTGKSLTSTK NTPTGPGSTF PDVKPDLEDV
DGVLFVSFES KEALDIHAVD GTTEESSSLQ ASATNDPGCR ARISQLEKEL IEDLKALRHK
QVIHPGLQEV GLKLNSVDPA MSIDLKYLGV QLPLAPATSF PFWNLTGTNP ASPDAGFPFV
SRTGKTNDFT KIKGWRGKFH SASASRNEGG NSEGSLKNRS AFCSDKLDEY LENEGKLMET
SMGFSSNAPT SPVVYQLPTK STSYVRTLDS VLKKQSTISP STSYSLKPHS VPSVSRKAKS
QNKQAPFSGR TKSSYKSILP YPVSPKQKHS HTIPGDKVTK NSSTTISENR VNNLVVPTLD
ENTFPKQISL RQAHQQQQQQ QQQGTRPPGL SKSQVKLMDL EDCALWEGKP RTYITEERAD
VSLTTLLTAQ ASLKTKPIHT IIRKRAPPCN NDFCRLGCVC SSLALEKRQP AHCRRPDCMF
GCTCLKRKVV LVKGGSKTKH FQRKTAHRDP VFYDNLGEEQ REEGEEGVRE EEEQLKEKKK
RKKLEYTICE TEPEQPVRHY PLWVKVEGEV DPEPVYIPTP SVIEPMKPLL LPQPEVLSTT
VKGKLLTGIK PARAYTPKPN PVIREEDKDP VYLYFESMMT CARVRVYERK QEEQRQPSPS
PSPSFQQQGS CHSSPENCSV KEPDSEQQPL KPITCDLEDD SDKSQEKSWK SSCNEGESSS
TSYVHQRSPG GPTKLIEIIS DCNWEEDRNK ILSILSQHIN SNMPQSLKVG SFIIELASQR
KSRGEKNPPV YSSRVKISMP SCQDQDDMAE KSGSETPDGP LSPGKMDDIS PVQTDALDSV
RERLHGGKGL PFYAGLSPAG KLVAYKRKPS SSTSGLIQVA SNAKVAASRK PRTLLPSTSN
SKTASSSSAT TNRPGKNLKA FVPAKRPIAA RPSPGGVFTQ FVMSKVGALQ QKIPGVSTPQ
PLTGPQKFSI RPSPVMVVTP VVSSEPVQVC SPVTAAVTTT TPQVFLENVT AVTPVTAISD
VGTKETTYSS GATTAGVVEV SETNTSTLVT PTQSTATVNL IKTTGITTPV ASVAFPKSLV
ASPPTITLPV ASTASTSIVV VTTAASSSMV TTPTSSLSSV PIILSGIDGS PPVSQRPENA
PQIPVATPQV SPNTVKRAGP RLLLIPVQQG SPTLRPVPNT QLQGHRMVLQ PVRSPSGMNL
FRHPNGQIVQ LLPLHQLRGS NTQPNLQPVM FRNPGSVMGI RLPTPSKPSE TPPSSASSSS
FSVMNPVIQA VGSSPAMNVI TQAPSLLSSG PSFVSQSGTL TLRISPPEPQ SFASKTGSET
KITYSSGGQP VGTASLIPLQ SGSFALLQLP GQKPVPSSIL QHVASLQMKR ESQNADQKDE
TSFLKREQET KKALQSGGEA IDPEANIIKQ NSGATVSEET LNDSLEDGGD HLDEESLTEE
GPATVKPSQH AYSTGSHTGE DYKNVDEEYG IRNHNSSKEK LTVLEVKTIS GRASNMTVQS
VSNVQLKKLD VKVEQQKGLD NPGEKSNEFP IISKEESKLE FSGSRVVEQQ SNPKPEAKEK
GCGDSLEKDS IRERWRKHLK GPLTQKCVRT SQECKKETDE QLIKETETCQ ENSDVFQQEH
GISDLLGKSG ATENARILKT ECDSWSRISS PAAFSIFPRR ATKGSRGEGH FQGHLLLSGE
QIKPKQEKKG GRSSADFTVL DLEEDDEEDE NEKTDDSIDE IVDVVSDYQS EEVDDVEKNN
CVEYIEDDEE QVDIETVEEL PEEVNVVHMK TTAAHTQTFK QLCRTHITTD EKAAEKSRKA
TPVPLKLKPD YWSEKLQKEA EAFAYYRRTH TANERRRRGE MRDLFEKLKI TLGLLHSSKV
SKSLILTRAF SEIQGLTDQA DKLIGQKNLL TRKRNILIRK VSSLSGKTEE VVLKKLEYIY
AKQQALEAQK RKKKMGSDEF DVSPRTSKQQ EGSSASSVDL GQMFINNRKG KPLILSRKKD
QATENTSPSN TPHTSANIVM TPQGQLLTLK GPLFSGPVVT VSPALLEADL KPQVASSAVA
QSENDDLFMM PRIVNVTSLA TEGGLVDMGG SKYPHEVPDG KLPDHLKNTV RNEDNSCEDL
GRISSRGNHR DVRMALGTTQ VYLSNKDSGF PQIVDVSSMQ EAQEFLPKKI SSDMRGIQHK
WKESESRRER LKTKESPFHK LKMKDLKDSS IEMELRKVAS AIEDAALDPS ELLTNMEDED
DTDETLTSLL NEIAFLNQQL NDDSVNLAEL PSSMDTEFPG DARQAFISKL PPGNRATFQV
GHLGTGLKEL PDVQGESDSV SPLLLHLEDD DFSENEKQLA EPASEPDVLK IVIDSEIKDS
LVSHRKAGDE GKSTSGIPAE PESVSSPPIL HMKAGLENSS TDTLWRPMPK LAPLGLKVAN
PSSDADGQSL KVMPCLAPVA AKAGSVGHKM NLTGNDQECR DSKMMPTLAP VVAKLGNSGA
SPSSAGK
//
