ID   A0A340XMQ7_LIPVE        Unreviewed;       835 AA.
AC   A0A340XMQ7;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO3 {ECO:0000313|RefSeq:XP_007462671.1};
OS   Lipotes vexillifer (Yangtze river dolphin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Lipotidae; Lipotes.
OX   NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007462671.1};
RN   [1] {ECO:0000313|RefSeq:XP_007462671.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_007462671.1; XM_007462609.1.
DR   AlphaFoldDB; A0A340XMQ7; -.
DR   GeneID; 103084063; -.
DR   CTD; 63982; -.
DR   OrthoDB; 534027at2759; -.
DR   Proteomes; UP000265300; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF16; ANOCTAMIN-3; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        249..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        326..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        401..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        445..468
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        496..519
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        613..635
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        663..687
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        760..789
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          11..235
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          238..803
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   835 AA;  98403 MW;  BF4E4F13F63C57E9 CRC64;
     MNYIASSGLL FKDGKKRIDY ILVYRKSNIQ YDKRNTFEKN LRAEGLMLEK EPAVANPDIM
     FIKIHIPWDT LCKYAERLNI RMPFRKKSYY TDQRSKSMGR VQKYFRRIKK WMSQNPMVLD
     KSAFPDLEES DCYTGPFSRA RIHHFIINNK DTFFSNATRS RIVYHMLQHT KYENGISKVG
     ICKLINNGSY IAAFPPHEGA YKSNQPIKTH GPQNNRHLLY ERWARWGMWY KHQPLDLIRL
     YFGEKIGLYF AWLGWYTGML IPAAIVGLCV FFYGILTMNA SQVSQEICKA TEVFMCPLCD
     KNCSLQRLNE SCIYAKVTYL FDNGGTVFFA IFMAIWATVF LEFWKRRRST LTYTWDLIEW
     EEEEETLRPQ FEAKYYKMER VNPISGKPEP HQPSSDKVTR LLVSISGIFF MISLVITAVF
     AVVVYRLIVM EQFASFKWNF IKQHWQFATS AAAVCINFVI IMALNLAYEK IAYLLTNLEY
     PRTESEWENS FALKMFLFQF VNLNSSIFYI AFFLGRFVGH PGKYNKLFNR WRLEECHPSG
     CLIDLCLQMG VIMFLKQIWN NFMELGYPLI QNWWSRHKIK RGIQDASIPQ WENDWNLQPM
     NIHGLMDEYL EMVLQFGFTT IFVAAFPLAP LLALLNNIIE IRLDAYKFVT QWRRPLPARA
     TDIGIWYGIL EGIGILAVIT NAFVIAITSD YIPRFVYEYK YGPCASQFEY SESCLTGYVN
     NSLSFFDLSE LGMGKSGYCR YRDYRGPPWS SKPYEFTLQY WHILAARLAF IIVFEHLVFG
     IKSFIAYLIP DVPKNLYDRI RREKYLVQEM MYEAELEHLQ QQRRKSGHPV HHEWP
//