ID A0A340XNA7_LIPVE Unreviewed; 1747 AA.
AC A0A340XNA7;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Plexin-D1 {ECO:0000313|RefSeq:XP_007461627.1};
GN Name=PLXND1 {ECO:0000313|RefSeq:XP_007461627.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007461627.1};
RN [1] {ECO:0000313|RefSeq:XP_007461627.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR RefSeq; XP_007461627.1; XM_007461565.1.
DR STRING; 118797.A0A340XNA7; -.
DR GeneID; 103089796; -.
DR KEGG; lve:103089796; -.
DR CTD; 23129; -.
DR InParanoid; A0A340XNA7; -.
DR OrthoDB; 1387371at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12788; RasGAP_plexin_D1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF7; PLEXIN-D1; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 3.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|ARBA:ARBA00022777};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1094..1116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..368
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
SQ SEQUENCE 1747 AA; 193374 MW; 0246566B145BF95A CRC64;
MLNVAANHPN ASTVGLVLPP AAGTGGSRLL VGATYTGYGS AFFPRNRSLE DHRFENTPEI
AIRSLDARGD LAKLFTFDLN PSDDNILKIK QGAKEQHKLG FVRAFLHPPD PQSGAQTYAY
LALNSEARAG DKESQARSLL ARICLPRGAG GDAKKLTESY IQLGLQCAGG AGRGDLYSRL
VSVFPARELL FAVFERPQGA PAARTAQAAL CAFRFADVQA AIRAARTACF VEPAPDVVAV
LDSVVQGTGP ACERKRNIQL QPEQLDCGAA HLQPPLSILQ PLKASPVFRA TGLSSVAVAS
VGNYTVVFLG TVSGRLLKVN LNESMQVVSR KAVTVAYGEP VHHVMQFDPT DPSYLYLMTS
HQMARVKVAA CAVHTTCGDC VGAADAYCGW CALETRCTLQ QDCANSSQPR FWTSASEGPG
RCPAMTVLPA EIDVHQEYPG MILQISGSLP SLSGMEMACD YGNDIHTVAR VPGPAFGHQI
AYCNLLPRNR FPPFPPHQDH VTVEMAVRVN GQNIVRASFT IYDCGRVGQV YPHTACTSCL
SAQWPCFWCT QQHSCVSNQS RCEASPNPTS PQDCPQTLPS ALAPMPTGSS QSIPVHLANA
AFFQGAALEC SFGQEEIFEA VWVNESAVCC SQVVLHTTQK SQVFPLSLQL KGRPARFLDS
PDHMTVEVYN CAMGSPDCSQ CLGREDLGHL CVWSDGCRLR GTLQPLPDTC PAPEIRAIEP
LSGPLDGGTL LTIRGRNLGR RLSDVVRGVW IGSVACEPLA DRYTVSEEIV CATGPALGAF
SDVVTVNASK EGRSRERFSY VLPLVYSLEP AVGPKAGGTR ITIHGSDLHV GSELQVLVND
TEPCMELVRT DTSITCTVPG GALPAPVPVC VRFERRGCVR GNLTFWYKRN PVITAISPRR
SHVSGGRTIT VAGERFHMVQ KVSMAVHHIG REPTLCKVLN STLITCPSPG ALSNASAPVD
FLLNGRAYAD EAAVDEELLD PEEAQRGSRF RLDYLPDPQF STAKREKWIK HHPGEPLTLV
IHKEQDGLGL ESHEYRVKIG QVACDIQIVS ERVIHCSVNE SLGTGEGQLP ITIQVGNFNQ
TIATLQLGGS ETAIIVSIVI CSVLLLLSVV ALFVFCTKSR RAERYWQKTL LQMEEMESQI
REEIRKGFAE LQTDMTDLTK ELNRSQGIPF LEYKHFVTRT FFPKCSSLYE ERYVLPSQTL
NSPGSSLVQE THPLLGEWKI PESCRPNMEE GISLFSSLLN NKHFLIVFVH ALEQQKDFAV
RDRCSLASLM TIALHGKLEY YTGIMKELLV DLIDASAAKN PKLMLRRTES VVEKMLTNWM
SICMYSCLRE TVGEPFFLLL CAIKQQINKG SIDAITGKAR YTLNEEWLLR ENIEAKPRNL
NVSFQGCGMD SLSVRAMDTD TLTQVKEKIL EAFCKNVPYS QWPRAEDVDL EWFASSTQSY
ILRDLDDTSV VEDGRKKLNT LAHYKIPEGA SLAMSLTDKK DNTLGRVKDL DTEKYFHLVL
PTDELAEPKK SHRQSHRKKV LPEIYLTRLL STKGTLQKFL DDLFKAILSI REDKPPLAVK
YFFDFLEEQA EKRGISDPDT LHIWKTNSLP LRFWVNILKN PQFVFDIEKT DHIDACLSVI
AQAFIDACSI SDLQLGKDSP TNKLLYAKEI PEYRKIVQRY YKQIHDMTPL SEQEMNAHLA
EESRKYQNEF NTNVAMAEIY KYAKRYRPQI MSALEANPTA RRTQLQHKFE QVVALMEDNI
YECYSEA
//
