ID   A0A340XND4_LIPVE        Unreviewed;       812 AA.
AC   A0A340XND4;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Protocadherin gamma-A8 {ECO:0000313|RefSeq:XP_007460535.1};
GN   Name=PCDHGA8 {ECO:0000313|RefSeq:XP_007460535.1};
OS   Lipotes vexillifer (Yangtze river dolphin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Lipotidae; Lipotes.
OX   NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007460535.1};
RN   [1] {ECO:0000313|RefSeq:XP_007460535.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_007460535.1; XM_007460473.1.
DR   AlphaFoldDB; A0A340XND4; -.
DR   GeneID; 103074617; -.
DR   KEGG; lve:103074617; -.
DR   CTD; 9708; -.
DR   InParanoid; A0A340XND4; -.
DR   OrthoDB; 5402790at2759; -.
DR   Proteomes; UP000265300; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 5.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR032455; Cadherin_C.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   PANTHER; PTHR24028; CADHERIN-87A; 1.
DR   PANTHER; PTHR24028:SF72; PROTOCADHERIN GAMMA-A8; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   Pfam; PF16492; Cadherin_C_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; Cadherin-like; 6.
DR   PROSITE; PS00232; CADHERIN_1; 3.
DR   PROSITE; PS50268; CADHERIN_2; 6.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..812
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016309597"
FT   TRANSMEM        689..714
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          75..133
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          134..242
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          243..347
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          348..452
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          453..562
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          579..683
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   REGION          790..812
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   812 AA;  88644 MW;  7651D79B3A959740 CRC64;
     MATPKNYQGR GDLVLLCALL GTLGEIGRGQ IHYSVPEESD KGYFVGNISK DLGLELQELA
     QHGVHIVSKG RMQLFALNPG SGSLVTAGRI DREELCAQSA RCLVNINILV EDKGKLWGIE
     IEITDINDNN PKFQVDNLEV KINEIALPGT RYPLPGAVDP DVGLNSLQSY QLSPNHHFSL
     DVQTGDDGTI SPELVLQRAL DREEEAAHRL VLVASDGGEP RRSSTVHIRV TVLDTNDNAP
     VFAQPIYRVK VPENVPPGTR LLTVSASDPD EGTNGEVAYK FWKISEKQSR LFQLNENTGE
     ISTAKSLDYE ECAFYDMGIQ AEDVGALLGR TKVLISVEDV NDNRPEVTIT SLFSPVLENT
     LPGTVIAFLN VHDRDSGENG QVVCYTRDNL PFQLEKSIDN YYRLVIWEYL DREKISLYNI
     TVMASDLGTP PLSTEIHIAL HVADTNDNPP IFPHASYSAY IPENNPRGTS IFSVTAHDPD
     SNENARVVYS LAEDTIQGTP LSSYVSINSN TGVLYALRSF DYEQFRDLQM QVRASDSGDP
     PLSSNVSLSL FVLDQNDNMP EILYPMLPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ
     NAWLSYRLLK ASDPGLFAVG LHTGEVRTVR ALLDRDALKQ SLVVVVQDHG QPPLSATVSL
     TVAVADSIPD VLAELGSLES PASPDDSGLT LYLVVAVAAV SCVFLAFVIV LLALRLRRWH
     TSRLLQPSGG GLAGVPTSHF VGVDGVRAFL QTYSHEVSLT ADSRRSHMIF PQPNYADTLI
     SQESCEKSEP LCASDDSRFP IEDTPLVPDN TP
//