ID A0A340XQG7_LIPVE Unreviewed; 1907 AA.
AC A0A340XQG7;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRB {ECO:0000313|RefSeq:XP_007463603.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007463603.1};
RN [1] {ECO:0000313|RefSeq:XP_007463603.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
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DR RefSeq; XP_007463603.1; XM_007463541.1.
DR GeneID; 103076574; -.
DR CTD; 5787; -.
DR OrthoDB; 5402037at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 13.
DR CDD; cd14617; R-PTPc-B; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 14.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF2; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA; 1.
DR Pfam; PF00041; fn3; 14.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 16.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 15.
DR PROSITE; PS50853; FN3; 9.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_007463603.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1907
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016464224"
FT TRANSMEM 1526..1552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 113..205
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 291..379
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 552..639
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 640..730
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 731..818
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 819..915
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 997..1085
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1170..1266
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1267..1358
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1613..1873
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1788..1864
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1907 AA; 213866 MW; C13194AD6F2FD80F CRC64;
MRSHGAGLAL WTALSLLQTG LGEPVRCNFT LTESRVSSRS VSLQWRTLAS PCNFSLICSS
DTSGVACCHP VRIDNTTYGC NPKDLQAGTI YNFSIMSLDG EEKTVVLQTD PLPPARFEVN
KEKSNSTSLH VWWTPSSGKV TWYEVQLLDD NQQTQGAQIQ ERTSRNEHTF FNLTAGSKYK
IAITAVSGDK RSSTIYANGS TVPSPVEDIG ISAKTNSLLI SWSRGSGNVE RYQLILMDKG
ILVHGYAVDK STTSYAFHGL IPGHLYNVTI VTEAAGLQNY RWKPARTTPM EVSNLKVTND
GTLTSLKVKW QRPSGNVDFY NITLSHQGTI KEYRILTPQI TETQFKDLAP GRLYQVTISC
VSGELSAHKM AVGRTVPLAV LQLRVKHANE TSLSVMWQTP AAEWEKYIIS LIDRDLLLIH
KLLPKDAKEF TFTDLVPGRK YIATVSSISG DLKNSSSTKG RTVPAQVTGL HVANQGTTSS
LFTNWTQALG DIDFYQVLLI HENVVIKNES VSSETSRYSF HSLKSGSLYS MVVTTVSGGI
SSRQVVVEGR TVPSSVSGVR VNNSGRNDYL SISWLPAPGD VDNYVVTLSH DGRVVQSLVI
AKFVSECSFS SLTPGRLYNV TITTRSGKYE NHSFGQERTV PDKVQGVSIS NSARSDYLKV
SWVHATGDFD HYEVTIKNKN NFIQTKSIPK SENECIFVEL VPGRLYSVTV TTKSGQYEAS
EQGNGRTIPE AVKDLTLHNR STEDLQVTWT RADGDVDQYE IQLLFNDMKV FPPFHLVNTA
TEYRFTSLTP GRQYKILVLT ISGDVQQSAF IEGFTVPSAV KNIHVFPNGA TDSLTVNWTP
GGGDVDSYTV SAFRQNQKVE SQTVPKLVSE HTFHRLEAGE QYRIVIASVS GSQKNQVDVL
GRTVPASVQG ITADNAYSSH SLIVSWQKAV GVAERYDILL LSENGILLSN TSEAATTKQH
RFEDLTPGKK YKIQILTVSG GLFSKEAQTE GRTVPAAVTN LRITENTTRQ LSFSWTPSEG
ELKWYNIFLY NPDRTLQERA QVGPQVQSFS FQNLLQGRMY KMVIVTHSGE LSNESSIFGR
TVPASVSNLK GSNRNMTDSL WFTWSPASGD FDFYELILYN PNGTKKENWK DKDLTEWRFH
GLVPGRKYTL CVITHSGDLS NKVTGESRTA PSPPSLMSFA DVANTSLAIT WKGPPDWTDY
DDFELQWFPR DAVTVFNPYS NRKSEGRIVY GLRPGRSYQF SVKTVSGDSW KTYSKPIFGS
VRTKPDKIQN LHCRPQNSTA IACSWIPPDS DFDGYNIECR KMDTQEVEFS RKLEKEKSLL
NIMMLVPHKR YLVSIKVQSA GMSSEVVEDS TITMIDRPPP PPPHIRVNKK DVLISKSSIN
FTFNCSWFSD TNGAVKYFTV VVREADGSDE LKPEQQHPLP SYLEYRHNAS IRVYQTDYFA
SKCAESPDSN SKSFNIKLGA EMESLGGKCD PNQQKFCDGP LKPRTAYRIS IRAFTQLFDE
DLKEFTKPLY SDTFFSLPIT TESEPLFGVI EGVSAGLFLI GMLVAVVALL ICRQKASHGR
ERPSARLSIR RDRPLSVHLN LGQKGNRKTS CPIKVNQFEG HFMKLQADSN YLLSKEYEDL
KDVGRNQSCD IALLPENRGK NRYNNILPYD ASRVKLSNVD DDPCSDYINA SYIPGNNFRR
EYIATQGPLP GTKDDFWKMA WEQNVHNIVM VTQCVEKGRV KCDHYWPADQ DSLYYGDLIL
QMLSESVLPE WTIREFRICS EEQLDAHRLI RHFHYTVWPD HGVPETTQSL IQFVRTVRDY
INRTPGAGPT AVHCSAGVGR TGTFIALDRI LQQLDSKDSV DIYGAVHDLR LHRVHMVQTE
CQYVYLHQCV RDVLRARKLR SEQENPLFPI YENVNPEYHR DAGYSRH
//
