ID A0A340XR58_LIPVE Unreviewed; 1170 AA.
AC A0A340XR58;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=WD repeat-containing protein 35 {ECO:0000256|PIRNR:PIRNR037536};
GN Name=WDR35 {ECO:0000313|RefSeq:XP_007463806.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007463806.1};
RN [1] {ECO:0000313|RefSeq:XP_007463806.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: As a component of the IFT complex A (IFT-A), a complex
CC required for retrograde ciliary transport and entry into cilia of G
CC protein-coupled receptors (GPCRs), it is involved in ciliogenesis and
CC ciliary protein trafficking. {ECO:0000256|PIRNR:PIRNR037536}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|PIRNR:PIRNR037536}. Cytoplasm,
CC cytoskeleton, cilium basal body {ECO:0000256|PIRNR:PIRNR037536}.
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DR RefSeq; XP_007463806.1; XM_007463744.1.
DR AlphaFoldDB; A0A340XR58; -.
DR GeneID; 103071137; -.
DR KEGG; lve:103071137; -.
DR CTD; 57539; -.
DR OrthoDB; 148480at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0036064; C:ciliary basal body; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030991; C:intraciliary transport particle A; IEA:UniProtKB-UniRule.
DR GO; GO:0060271; P:cilium assembly; IEA:InterPro.
DR GO; GO:0035721; P:intraciliary retrograde transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.470; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR039857; Ift122/121.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR017233; WDR35.
DR PANTHER; PTHR12764:SF5; LD29485P; 1.
DR PANTHER; PTHR12764; WD REPEAT DOMAIN-RELATED; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 1.
DR PIRSF; PIRSF037536; WD_repeat_p35; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF69322; Tricorn protease domain 2; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|PIRNR:PIRNR037536};
KW Cilium {ECO:0000256|PIRNR:PIRNR037536};
KW Cilium biogenesis/degradation {ECO:0000256|PIRNR:PIRNR037536};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037536};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR037536};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 67..98
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 130..194
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
SQ SEQUENCE 1170 AA; 132360 MW; F1EF247E5A23AD69 CRC64;
MFFYLSKKIA IPNNVKLKCI SWNKDQGFIA CGGEDGLLKV LKLETQTDDA KLRGLAAPSN
LSMNQTLEGH SGSVQVVTWN EQYQKLTTSD QNGLIIVWML YKGSWYEEMI NNRNKSVVRS
MSWNADGQKI CIVYEDGAVI VGSVDGNRIW GKDLKGIHLC HVAWSADSKI LLFGMANGEI
HIYDNQGNFI MKMKLNCLVN VTGAVSIAGI HWYHGTEGYV EPHCPCLAIC FDNGRCQIMR
HENDQNPVLI DSGMYVVSIQ WNHTGSVLAV AGSQKAITQD KDVNTVQFYT PFGEHLGTLK
IPGKQMSALS WEGGGLKIAL AVDSFIYFAN IRPDYKWGYC SNTVVYAYTR PDRPEYCVIF
WDTKNNEKYV KYVKSLISIT TCGDFCILAT KADENHPQFV LVLCNSIGTP LDPKHIDLVP
LFVTMTKTHV IAASKEAFYT WQYRVAKKLT ALEINQITRS RKEGRERIYH VDDTPSGSVD
GVLDYSKAIQ GTRDPICAIT ASDKTLIVSR ESGTIQRYSL PNIGLIQKYS LNCRAYQLSL
NCNSSRLAII DISGVLTFFD LDARVTDSTG QQVIGELLKL ERKDVWDMKW AKDNPDLFAM
MEKTRMYVFR NLDPEEPIQT SGYICNFEDL EIKSVLLDEI LKNPEYPNKD YIINFEIRSL
RDSRALIEKV GIEDASQFIE DNPHPRLWRL LAEAALQKLD LHTAEQAFVR CKDYQGIKFV
KRLGNLQSES MKQAEVAAYF GRFEEAERMY LDMDRRDLAI GLRLKLGDWF RVLQLLKTGS
GDADDSLLEQ AHNAIGDYFA DRQKWLNAVQ YYVQGRNQER LAECYYMLED YEGLENLASS
LPENHKLLPE IAQMFVRAGM CEQAVTAFLK CNQPKAAVDT CVHLNRWNKA VELAKSHNMK
EIGSLLARYA SHLLEKNKIL DAIELYRKAS YFYDAAKLMF KIADEEAKKR TKPLRVKKLY
VLSALLIEQY HEQVKNAQRG KVKGKSSEAT SALAGLLEGE VLSTTSRFTD NAWRGAEAYH
FFVLAQRQLY EGCVDNALKT ALHLRDYEDI IPAVEIYSLL ALCACASRAF GTCSKAFIKL
ESLETLSSEQ KQQYENLALE IFTKHTPKDN RKSELDSLLE GGEGKLPTCV ATGNPVTEYQ
FWTCSVCKHC VLAQEISNYN FCPLCHSAVG
//
