ID   A0A340XTB5_LIPVE        Unreviewed;       905 AA.
AC   A0A340XTB5;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Flap endonuclease GEN homolog 1 {ECO:0000313|RefSeq:XP_007464523.1};
GN   Name=GEN1 {ECO:0000313|RefSeq:XP_007464523.1};
OS   Lipotes vexillifer (Yangtze river dolphin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Lipotidae; Lipotes.
OX   NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007464523.1};
RN   [1] {ECO:0000313|RefSeq:XP_007464523.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR   RefSeq; XP_007464523.1; XM_007464461.1.
DR   AlphaFoldDB; A0A340XTB5; -.
DR   STRING; 118797.A0A340XTB5; -.
DR   GeneID; 103076125; -.
DR   KEGG; lve:103076125; -.
DR   CTD; 348654; -.
DR   InParanoid; A0A340XTB5; -.
DR   OrthoDB; 26655at2759; -.
DR   Proteomes; UP000265300; Unplaced.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004520; F:DNA endonuclease activity; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   CDD; cd09869; PIN_GEN1; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR041012; GEN_chromo.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR006086; XPG-I_dom.
DR   InterPro; IPR006084; XPG/Rad2.
DR   InterPro; IPR006085; XPG_DNA_repair_N.
DR   PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR11081:SF73; FLAP ENDONUCLEASE GEN HOMOLOG 1; 1.
DR   Pfam; PF18704; Chromo_2; 1.
DR   Pfam; PF00867; XPG_I; 1.
DR   Pfam; PF00752; XPG_N; 1.
DR   PRINTS; PR00853; XPGRADSUPER.
DR   SMART; SM00279; HhH2; 1.
DR   SMART; SM00484; XPGI; 1.
DR   SMART; SM00485; XPGN; 1.
DR   SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759,
KW   ECO:0000313|RefSeq:XP_007464523.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265300}.
FT   DOMAIN          1..96
FT                   /note="XPG N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00485"
FT   DOMAIN          122..193
FT                   /note="XPG-I"
FT                   /evidence="ECO:0000259|SMART:SM00484"
FT   REGION          463..483
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          803..834
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        808..834
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   905 AA;  102502 MW;  DCC2EDDA8C054C5F CRC64;
     MGVNDLWQIL EPVKQHVHLH SLGGKTIAVD LSLWVCEAQT VKKMIGTVMK PHLRNLFFRI
     SYLTLMDVKL VFVMEGEPPQ LKADVISKRN QIRYGPSGKT WSQKTGRSHF KSVLKECLDM
     LECLGIPWVQ AAGEAEAMCA YLNASGYVDG CLTNDGDAFL YGAQTVYRNF TMNTKDPHVD
     CYTMSYIKSK LGLDRNALVG LAILLGCDYL PKGVPGVGKE QALKLIKILK GQSLLQRFNQ
     WNENFCYSNS QPAVVSKLAH CSLCSHPGSP KDHERNGCKL CKTDRYCEPH DYEYCCPCEW
     HRTEHERQLN AVENSIKKKA CSCAGFPFHE VIQEFLLNKD KLVMAIRYQR PDLLLFQRFA
     LEKMEWPSHY ACEKLLVLLT HYDMIERKLG RRNSNQLQPR RIVKNRIRNG VHCFEIEWEK
     PEHYSIEDKP GELVLQTIEE ESLFEAAYPE IVAVYQKQKS EIKGKKQKSM KTKSKGNNLP
     ESDDMMTFQS HMTLKPTCEI FSKQNSKLNL EISPDSTLPQ ESTVSLNTLL LPEDAPCLNT
     QEQLISSPRP LAVQQIKAIS KSLIAESSQP STSSHNISAI ADLHLSTIDW EGTSFSNFSA
     IPGNTFAHGV KSELETAIPD SFKNITEQLS CESEWCTTNI KKQFDWDLQK TDPEEHLLSG
     ITDLHLQDLP LKERIHIKSY PQNNVQPDDL KTLSLLTVQE HCIANRSSEC LSHLSKDLLG
     IHLQNESRNC KVLKGNQLFP ENCKANTCIP YSVDNPIVKT SSVRTGPPNT ALDYSRKVDV
     QTTRKTVMKK SVCLDKHSSG EEIIPESGKA KSTTQKMKLS SQKHSPAQFK KNDANKLSNP
     KARIKETEQC VQPYKTAGNE ETRFQDAAKW SLSFLQCRKE KDVSGTCLDS PLPLSQRLKL
     RFQNT
//