ID A0A340XTJ5_LIPVE Unreviewed; 220 AA.
AC A0A340XTJ5;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Metalloproteinase inhibitor 2 {ECO:0000256|ARBA:ARBA00013520};
DE AltName: Full=Tissue inhibitor of metalloproteinases 2 {ECO:0000256|ARBA:ARBA00030102};
GN Name=LOC103070305 {ECO:0000313|RefSeq:XP_007462420.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007462420.1};
RN [1] {ECO:0000313|RefSeq:XP_007462420.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts (via the C-terminal) with MMP2 (via the C-terminal
CC PEX domain); the interaction inhibits the MMP2 activity.
CC {ECO:0000256|ARBA:ARBA00011847}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I35 (TIMP) family.
CC {ECO:0000256|ARBA:ARBA00011027}.
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DR RefSeq; XP_007462420.1; XM_007462358.1.
DR AlphaFoldDB; A0A340XTJ5; -.
DR STRING; 118797.A0A340XTJ5; -.
DR GeneID; 103070305; -.
DR KEGG; lve:103070305; -.
DR InParanoid; A0A340XTJ5; -.
DR OrthoDB; 5403389at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd03585; NTR_TIMP; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 3.90.370.10; Tissue inhibitor of metalloproteinase-1. Chain B, domain 1; 1.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR001820; TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR InterPro; IPR027465; TIMP_C.
DR InterPro; IPR030490; TIMP_CS.
DR PANTHER; PTHR11844; METALLOPROTEASE INHIBITOR; 1.
DR PANTHER; PTHR11844:SF24; METALLOPROTEINASE INHIBITOR 2; 1.
DR Pfam; PF00965; TIMP; 1.
DR SMART; SM00206; NTR; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50189; NTR; 1.
DR PROSITE; PS00288; TIMP; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601820-3};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601820-1};
KW Metalloenzyme inhibitor {ECO:0000256|ARBA:ARBA00023215};
KW Metalloprotease inhibitor {ECO:0000256|ARBA:ARBA00022608};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR601820-1}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..220
FT /note="Metalloproteinase inhibitor 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016283069"
FT DOMAIN 27..152
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT BINDING 27
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="ligand shared with metalloproteinase partner"
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-1"
FT SITE 40
FT /note="Involved in metalloproteinase-binding"
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-2"
FT SITE 67
FT /note="Involved in metalloproteinase-binding"
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-2"
FT DISULFID 27..98
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 29..127
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 39..152
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 154..201
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 159..164
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 172..193
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
SQ SEQUENCE 220 AA; 24401 MW; FFCEF3E300903A21 CRC64;
MGAAARSLRL VLGLLLLGTL LRPTDACSCS PVHPQQAFCN ADVVIRAKAV SEKEVDSGND
IYGNPIKRIQ YEIKQIKMFK GPDKDIEFIY TAPSSAVCGV SLDIGGKKEY LIAGKAEGNG
KMHITLCDFI VPWDTLSTTQ KKSLNHRYQM GCECKITRCP MIPCYISSPD ECLWMDWVTE
KSINGHQAKF FACIKRSDGS CAWYRGAAPP KQEFLDIEDP
//
