ID A0A340XTQ7_LIPVE Unreviewed; 669 AA.
AC A0A340XTQ7;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Zinc transporter ZIP4 {ECO:0000256|ARBA:ARBA00039394};
DE AltName: Full=Solute carrier family 39 member 4 {ECO:0000256|ARBA:ARBA00042777};
DE AltName: Full=Zrt- and Irt-like protein 4 {ECO:0000256|ARBA:ARBA00041703};
GN Name=SLC39A4 {ECO:0000313|RefSeq:XP_007464663.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007464663.1};
RN [1] {ECO:0000313|RefSeq:XP_007464663.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004424}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Recycling endosome membrane
CC {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004195}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
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DR RefSeq; XP_007464663.1; XM_007464601.1.
DR AlphaFoldDB; A0A340XTQ7; -.
DR STRING; 118797.A0A340XTQ7; -.
DR GeneID; 103072510; -.
DR KEGG; lve:103072510; -.
DR CTD; 55630; -.
DR InParanoid; A0A340XTQ7; -.
DR OrthoDB; 5488029at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR049406; ZIP4_12_EF-hand.
DR InterPro; IPR041137; ZIP4_N.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR PANTHER; PTHR12191:SF21; ZINC TRANSPORTER ZIP4; 1.
DR Pfam; PF21116; EF-hand_Zip; 1.
DR Pfam; PF02535; Zip; 1.
DR Pfam; PF18292; ZIP4_domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..38
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 39..669
FT /note="Zinc transporter ZIP4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016276695"
FT TRANSMEM 350..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..628
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 640..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..213
FT /note="Zinc transporter ZIP4 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18292"
FT DOMAIN 219..331
FT /note="Zinc transporter ZIP4/12 EF-hand"
FT /evidence="ECO:0000259|Pfam:PF21116"
FT REGION 253..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 669 AA; 70304 MW; 0881D73835B8B878 CRC64;
MASLELRAPG GRSLAGPAGP KLGLLLALLA VLPLTGTATP PARLLTLLSS GRGVLDRKAL
GSLLNTLAVR VHCADGPCGK CLSVEDALAL GRPEKPGLHT APALEPRHIA RLSAAAALYL
SNPEGTCADV RAGRWASRAD QLLALLERPE ALAPGLARLL QKIEAQAAGR PASAEACVDL
PQLLEEAAGV GSPGSPGPVL AALLDHVGSG SCFGALPSPQ YFVDFVFRQH GRENPNITLA
ELEALMQRLG VGGATETHGD HSDHRHRGEG ANRRGPVPPA TPNSSSSMWD TVCLSAGDVM
AVYGLSEQAG VTPEAWAQLS PALLQQQLSG ACSPQPEQPT QDQLSQVQRY LYGSLATLLI
CLSSVFGLLL LTCAKCSTAT HYIIQTFLSM AVGALTGDAL LHLTPQVLGL HSHDGEGLGS
QPTWRLLAVL GGLYAFFLFE SLFNLLLPVD PEDRKDGPCS HGHSHGGHSH GVSLQLAPSD
LRPPKQPHEG SRADLVAEES PELLSPEPRR PSPELRLLPY VITLGDAVHN FADGLAVGAA
FSSSWKTGLA TSLAVFCHEV PHELGDFAAL LHAGLSVRLA LLLNLASGLT AFIGLYVALA
VGVGEDGETW ILAVATGLFL YVALCDMLPA TLNVRDRRPW LVFLLHNVGL LGGWTVLLLL
SLYEDNITL
//
