ID A0A340XV38_LIPVE Unreviewed; 2174 AA.
AC A0A340XV38;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Voltage-dependent T-type calcium channel subunit alpha-1G isoform X46 {ECO:0000313|RefSeq:XP_007465113.1};
GN Name=CACNA1G {ECO:0000313|RefSeq:XP_007465113.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007465113.1};
RN [1] {ECO:0000313|RefSeq:XP_007465113.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007465113.1; XM_007465051.1.
DR GeneID; 103083354; -.
DR CTD; 8913; -.
DR OrthoDB; 1110761at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR005445; VDCC_T_a1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF137; VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR01629; TVDCCALPHA1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 744..762
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 865..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 941..964
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1254..1272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1292..1313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1325..1344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1389..1411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1491..1514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1578..1599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1611..1634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1712..1731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1795..1817
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 80..405
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 743..972
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1252..1524
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1577..1827
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1024..1208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1844..1881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1981..2174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1523..1557
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 470..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..509
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1095
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1161..1176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2017..2059
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2067..2081
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2174 AA; 241701 MW; DE4FAF5B888DC6DB CRC64;
MDEEEDGAGA EESGQPRSFM QLNDLSGAVG RPGPGSAEKD PGSVDSEAEG LPYPALAPVV
FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF
DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR
TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR
CFLPENFSLP LSVDLERYYQ TENEDENPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL
DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM
YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA
STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RAGLLSSPAP RGSQEPQPSG
SCPRSHRRPS VHHLVHHHHH HHHHYHLGNG TLRVPRASPQ IQDKDANGSR RLMLPPPSTL
ALSGGPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTMHTSPPPE
MLKEKALMEV APTSGPPTLT SLNIPPRSYS SMHKLLETQS TGACQSSCKI SSPCLKADSG
ACGPDSCPYC VRTGAGEVEL TGHEMPDSDS EAVYEFTQDA QHGDRQNPHS WRRRSLGLDV
EPNSVLALWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI
VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR
VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL
PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV
AILVEGFQAE GDATKSESEP DFFSPSLDGD GDRKRRLALV SLGEHPELRR SLLPPLIIHT
AATPMSLPKS SSTGPAEALG PASRRASSSG SAEPGAPHEM KSPPSARSSP HSPWSAASRW
TSRRSSRNSL GRAPSLKRRS PSGERRSLLS GDGQESQDEQ ESSEEERASP AGSDRRRRGS
LEREAKSSFD LPDTLQVPGL HRTASGRSSA SEHQDCNGKS APGRLTRALR PDDPPLDGDD
GDDEGNLSKG ERMRAWVRAR LPACCLERDS WSAYIFPPQS RFRLLCHRII THKMFDHVVL
VIIFLNCITI AMERPKIDPH SAERIFLTLS NYIFTAVFLA EMTVKVVALG WCFGEQAYLR
SSWNVLDGLL VLISIIDILV SMVSDSGTKI LGMLRVLRLL RTLRPLRVIS RAQGLKLVVE
TLMSSLKPIG NIVVICCAFF IIFGILGVQL FKGKFFVCQG EDTRNITNKS DCAEASYRWV
RHKYNFDNLG QALMSLFVLA SKDGWVDIMY DGLDAVGVDQ QPVMNHNPWM LLYFISFLLI
VAFFVLNMFV GVVVENFHKC RQHQEEEEAR RREEKRLRRL EKKRRSKEKQ MAEAQCKPYY
SDYSRFRLLV HHLCTSHYLD LFITGVIGLN VVTMAMEHYQ QPQILDEALK ICNYIFTVIF
VLESVFKLVA FGFRRFFQDR WNQLDLAIVL LSIMGITLEE IEVNASLPIN PTIIRIMRVL
RIARVLKLLK MAVGMRALLD TVMQALPQVG NLGLLFMLLF FIFAALGVEL FGDLECDETH
PCEGLGRHAT FRNFGMAFLT LFRVSTGDNW NGIMKDTLRD CDQESTCYNT VISPIYFVSF
VLTAQFVLVN VVIAVLMKHL EESNKEAKEE AELEAELELE MKTLSPQAPS PPGSPFLWPG
VEGPDSPGSP KPGAPHAAAH TEAVSHFSLE HPMVSKHPLR LKGVPDLLTV RKSGVSRTHS
LPNDSYMCRD GSTAEGSLGH RGWGLPKAQS GSVLSVHSQP ADTSYILQLP KDAPHLLQPH
GAPTWGTIPK LPPPGRSPLA QRPLRRQAAI RTDSLDVQGL DSREDLLSEE EAPSPRDLKK
CYSVEARGRP RRPASWLDEQ RRHSIAVSCL DSGSQPRLGP GPSSLRGQPL GGPGSRPKKK
LSPPSISIEP PESQSQGPRP PPSPGVCLRR RAPSSDSKDP SASGPPDSMA ASPPAKKDVL
SLSGLSSDPA DLDP
//
