ID A0A340XYH7_LIPVE Unreviewed; 1060 AA.
AC A0A340XYH7;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Guanine nucleotide exchange factor DBS {ECO:0000313|RefSeq:XP_007466426.1};
GN Name=MCF2L {ECO:0000313|RefSeq:XP_007466426.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007466426.1};
RN [1] {ECO:0000313|RefSeq:XP_007466426.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_007466426.1; XM_007466364.1.
DR AlphaFoldDB; A0A340XYH7; -.
DR STRING; 118797.A0A340XYH7; -.
DR GeneID; 103073902; -.
DR KEGG; lve:103073902; -.
DR CTD; 23263; -.
DR InParanoid; A0A340XYH7; -.
DR OrthoDB; 4244290at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01227; PH_Dbs; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR035534; DBS_PH.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR22826:SF115; GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00435; Spectrin; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300}.
FT DOMAIN 22..194
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 598..778
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 796..912
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 526..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..592
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1060 AA; 120051 MW; 4CD172F5A17D6DC4 CRC64;
MRFWLRNDEM ALEEMVQRLN AVSKRTDEIM HHDISPLCAA DIQDQLQKRF AYLSGGRGQD
GSPVITFPNY PAFGDVPDKE FQNVMTYLTS IPSLQDAGIG FILVIDRRQD KWTSVKASIL
RIAASFPANL QLVLVLRPTG FFQRTLSDLA FRFNRDDFKM KVPVIMLSSV PELHSYIDKS
QLTEDLGGTL DYCHSRWLCH RTAIESFALL VKQTAQMLQA FGTELAETEL PNDAQATRSV
LRAHAEKKGK AKEDMRLALD EGRSVLESIR EPLARGPEQS PNQDQLDSQS TVQRLLAQLN
ETEAAFDEFW AKHQQKLEQC LQLRHFEQDF REVKAALDVL AQKITTFTDV GNSLAHVQHL
LKDLASFEEK SSAVAQRARA LALEGERLIE LKHYAVDSIR PKCHELRQLC DQFAADVGQR
RGLLGRALDL HGLLEASMKW CDEGIYLLAS QPVDRCQSQD GAEAALQEIE KFLETGAENK
IQELSKIYQD YEPILTRDLL EHVQKVFRKQ ESVEEMFHRR QASLRKLAAK QTRPVQPVAP
RPEAPAKSPC PSPGIRRGSE NHSSEGSVLR RGPYRRARSE ASEGRGRPAG EEESLAVLRR
HVMNELLDTE RVYVEELLCI LEGYAAEMDN PLMTHLISTG LQNKKDVLFG NMEEIYHFHN
RIFLRELENY IDCPELVGRC FLERMEQFQV YEQYCQNKPR SESLWRQCSD CPFFQECQKK
LDHKLSLDSY LLKPVQRITK YQLLLKEMLK YSKSCEGAED LQEALSSILG ILKAVNDSMH
LIAITGYEGN LSDLGKLLMQ GSFSVWTDHK KGHAKVKDLA RFKPMQRHLF LHEKAVLFCK
RREEGGQGYE KAASYSFKQA LNMTAVGITE NVKGDAKKFE IWYNTREEVY IVQAPTPEIK
ATWVSEIRKV LTSQLQACRE ASQHRALEQS HSLPLPAPAG TSPSKGNTKD VRKLEERKTA
PLNLEGYVGP APLPRPPEKG RGWSKTSNPP EAPEDNDGWS SAEEPVNSSD AEEEGRAGLR
KLVPGKYTVT GLDEKGGPDA LVLRSGDEVE LVQEGDEGLW
//