ID A0A340XZ05_LIPVE Unreviewed; 956 AA.
AC A0A340XZ05;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=LOW QUALITY PROTEIN: toll-like receptor 3 {ECO:0000313|RefSeq:XP_007466611.1};
GN Name=TLR3 {ECO:0000313|RefSeq:XP_007466611.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007466611.1};
RN [1] {ECO:0000313|RefSeq:XP_007466611.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007466611.1; XM_007466549.1.
DR STRING; 118797.A0A340XZ05; -.
DR GeneID; 103081090; -.
DR KEGG; lve:103081090; -.
DR CTD; 7098; -.
DR InParanoid; A0A340XZ05; -.
DR OrthoDB; 3428126at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR041015; TLR3_TMD.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF524; TOLL-LIKE RECEPTOR 3; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF01582; TIR; 1.
DR Pfam; PF17968; Tlr3_TMD; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 9.
DR SMART; SM00369; LRR_TYP; 18.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 6.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_007466611.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 756..777
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 806..949
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 956 AA; 109371 MW; CB4F10DA980F521C CRC64;
MKTTGFGLTK NGXSCRQSFR IFLVDDLSSD VSEESVSFSF FTHPXLAFGK IMSRDLLCRI
YSFWGLLPFW ILCTSSTNKC TVRREIADCS HLKLTQIPDD LPTNITVLNL THNQLRRLPP
ANFTRYSQLT ILDGGFNSIS KLEPELCQSL PLLEILNLQH NELSQLSDKT FIFCMNLTEL
HLMSNSVQKI QSNPFKNLKN LIKLDLAHNG LSSTKLGTQL QLENLQELLL SNNKISALRR
EELDFLGNSS LKRLELSSNQ IKEFSPGCFH AIGKLFGFSL NNAKLSPSLI EELCLELSNT
SIQNLSLSNN QLYTTSNTTF VGLKQTNLTM LDLSHNSLSV IGNDSFAWLP HLEYLFLEYN
NIEHLSSRSF YGLSNVRYLN LRRSFTKQSI SLASLPKIDD FSFQWLQFLE YLSMEDNTLP
GIKNNTFTGL TRLRCLSLSN SFSSLRTLTN ETFLSLAGSP LLILNLTKNK ISKIESGAFS
WLGHLNVLDL GLNEIGQELT GQEWRGLENI VEIYLSYNKY LELTSNSFAL VPSLQRLMLR
RVTLKNVDSS PSPFHPLPNL TILDLSNNNI ANINDELLKG LEKLEILDLQ HNNLARLWKH
ANPGGPVHFL KGLSHLHILN LESNGFDEVP AEVFKDLHEL KSINLGLNNL NILPPSVFDN
QVLLKSLSLQ KNLITSVEKN VFGPAFKNLS NLDMSFNPFD CTCESIAWFV TWINNSHTNI
SELSSRYLCN TPPQYRGFPV MLFDISPCKD SAPFELLFMI NTSILLIFIL IVLLIHFEGW
KISFYWNVSV HRVLGFKEID RQPEQFEYAA YIIHAYKDRD WVWEHFSPME EEDHTLRFCL
EERDFKAGVL ELEAIVNSIR RSRKIIFVIT QNLLKDPLCK RFKVYHAVQQ AIEQNLDSII
LIFLEDIPDY KLNHALCLRR AMFKSHCILN WPVQKERVNA FHHKLQVALG SRNSVH
//
