ID A0A340XZG6_LIPVE Unreviewed; 632 AA.
AC A0A340XZG6;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Methyl-CpG-binding domain protein 1 isoform X7 {ECO:0000313|RefSeq:XP_007465642.1};
GN Name=MBD1 {ECO:0000313|RefSeq:XP_007465642.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007465642.1};
RN [1] {ECO:0000313|RefSeq:XP_007465642.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_007465642.1; XM_007465580.1.
DR AlphaFoldDB; A0A340XZG6; -.
DR GeneID; 103086301; -.
DR CTD; 4152; -.
DR OrthoDB; 5262043at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd01396; MeCP2_MBD; 1.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR002857; Znf_CXXC.
DR PANTHER; PTHR12396; METHYL-CPG BINDING PROTEIN, MBD; 1.
DR PANTHER; PTHR12396:SF59; METHYL-CPG-BINDING DOMAIN PROTEIN 1; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF02008; zf-CXXC; 3.
DR SMART; SM00391; MBD; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS51058; ZF_CXXC; 3.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00509}.
FT DOMAIN 1..69
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 169..216
FT /note="CXXC-type"
FT /evidence="ECO:0000259|PROSITE:PS51058"
FT DOMAIN 217..263
FT /note="CXXC-type"
FT /evidence="ECO:0000259|PROSITE:PS51058"
FT DOMAIN 357..405
FT /note="CXXC-type"
FT /evidence="ECO:0000259|PROSITE:PS51058"
FT REGION 80..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..94
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..334
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 632 AA; 69947 MW; 8504BDA1C78117EB CRC64;
MAEDWLDCPA LGPGWKRREV FRKSGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT
LFDFKQGILC YPAPKAHSLA IPSRKRKKPS KPAKAQKRQV GPSKSEVRKE APRDETKADA
DTVPASLPAP GCCENCGISF SGDGTRRQRL KTLCKDCRAQ RIAFNREQRM FKRVGCGECA
ACQVTEDCGA CSTCLLQLPH DVASGLFCKC ERRRCLRIVE RSRGCGVCRG CQTREDCGRC
RVCLRPPRPG LRRQWRCVQR RCLRHLAHRL RRRHHQRCQR RPPLAVAPPA GKHGRRRGGC
DSKVAPRRRP PRTQPLPALP PSQPPESPEL HPRALAPSPP AEFIYYCVDE DELQPYTNRR
QNRKCGACAA CLRRMDCGHC DFCCDKPKFG GSNQKRQKCR WRQCLQFAMR LLPSVWAGSE
DGTRPPTPYP RRKRPGSARR PRLGQTPKPP LATPMAQPDR AQTPVKQEAG SGFVLPPPGT
DLVFLREGAS SPVQVPGPAP ASTTALLQEA QCPGLSWVVA LPQVKQEKAD AQEDWTPGTA
ILTSPVLLPG CPSKAVDPGL PPVKQEPPDP EEDKEEANKD DPTADLAPEE EAGGAGTPVI
TEIFSLGGTR LRDTAVWLPR SKDLKKPGAR KQ
//
