ID A0A340XZW9_LIPVE Unreviewed; 516 AA.
AC A0A340XZW9;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Recombining binding protein suppressor of hairless-like protein {ECO:0000313|RefSeq:XP_007464849.1};
GN Name=RBPJL {ECO:0000313|RefSeq:XP_007464849.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007464849.1};
RN [1] {ECO:0000313|RefSeq:XP_007464849.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Su(H) family.
CC {ECO:0000256|ARBA:ARBA00009704}.
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DR RefSeq; XP_007464849.1; XM_007464787.1.
DR AlphaFoldDB; A0A340XZW9; -.
DR STRING; 118797.A0A340XZW9; -.
DR GeneID; 103080331; -.
DR KEGG; lve:103080331; -.
DR CTD; 11317; -.
DR InParanoid; A0A340XZW9; -.
DR OrthoDB; 1384914at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd01176; IPT_RBP-Jkappa; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.1450; LAG1, DNA binding domain; 1.
DR InterPro; IPR015350; Beta-trefoil_DNA-bd_dom.
DR InterPro; IPR036358; BTD_sf.
DR InterPro; IPR040159; CLS_fam.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR015351; RBP-J/Cbf11/Cbf12_DNA-bd.
DR InterPro; IPR037095; RBP-J/Cbf11_DNA-bd_sf.
DR InterPro; IPR038007; RBP-Jkappa_IPT.
DR PANTHER; PTHR10665; RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS; 1.
DR PANTHER; PTHR10665:SF2; RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS-LIKE PROTEIN; 1.
DR Pfam; PF09270; BTD; 1.
DR Pfam; PF09271; LAG1-DNAbind; 1.
DR Pfam; PF20144; TIG_SUH; 1.
DR SMART; SM01268; BTD; 1.
DR SMART; SM01267; LAG1_DNAbind; 1.
DR SUPFAM; SSF110217; DNA-binding protein LAG-1 (CSL); 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 67..205
FT /note="RBP-J/Cbf11/Cbf12 DNA binding"
FT /evidence="ECO:0000259|SMART:SM01267"
FT DOMAIN 206..358
FT /note="Beta-trefoil DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01268"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 516 AA; 56105 MW; 2BDA21AFE46867C0 CRC64;
MDPVGADPSA HPGPLTHLSL PDSSEARPQS GADGRSLPGS WTRSSPEPAT VLREGVRQCL
QQQCEQTVQI LHAKVAQKSY GNEKRFFCPP PCVYLAGPGW RVKPVQGQAH QAGETGPIVC
GYMGLDGASG SAVETQKLNF EEQPDSREFG CAKTLYISDA DKRKHFRLVL RLVLRGGREL
GTFHSRLIKV ISKPSQKKQS LKNTDLCISS GSKVSLFNRL RSQTVSTRYL SVEDGDFVAS
ARQWAAFTLH LADEHCSQGD FPPREGYVHY GSLVQLICTV TGITLPPMII RKVAKQCALL
DVDEPISQLH KCAFQFPGGP PGGGGTYLCL ATEKVVQFQA SPCPKEANKA LLNDSSCWTI
IGTESVEFSF STSLACTREP VTPVPLISTL ELSGGGDVAT LELHGENLHA GLKVWFGEVE
AETMYRSPRS LVCVVPDVAA FGSDWRWLRT PITVPVSLVR ADGLFYPSAF SFTYTPEYSV
RSGPPGASAP ASDADALLES IHHEFTRTNF HLFIQT
//
