ID A0A340Y1U6_LIPVE Unreviewed; 225 AA.
AC A0A340Y1U6;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Transmembrane emp24 domain-containing protein 5 {ECO:0000256|ARBA:ARBA00017084};
GN Name=LOC103086775 {ECO:0000313|RefSeq:XP_007467626.1};
GN Synonyms=TMED5 {ECO:0000313|RefSeq:XP_007468613.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007467626.1};
RN [1] {ECO:0000313|RefSeq:XP_007467626.1, ECO:0000313|RefSeq:XP_007468613.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Potential role in vesicular protein trafficking, mainly in
CC the early secretory pathway. Required for the maintenance of the Golgi
CC apparatus; involved in protein exchange between Golgi stacks during
CC assembly. Probably not required for COPI-vesicle-mediated retrograde
CC transport. {ECO:0000256|ARBA:ARBA00025281}.
CC -!- SUBUNIT: Interacts with TMED9 and TMED10.
CC {ECO:0000256|ARBA:ARBA00011627}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Endoplasmic reticulum-Golgi
CC intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004151};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004151}.
CC Golgi apparatus, cis-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004619}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004619}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003827}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003827}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family.
CC {ECO:0000256|ARBA:ARBA00007104, ECO:0000256|RuleBase:RU003827}.
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DR RefSeq; XP_007467626.1; XM_007467564.1.
DR RefSeq; XP_007468613.1; XM_007468551.1.
DR STRING; 118797.A0A340Y1U6; -.
DR GeneID; 103077685; -.
DR GeneID; 103086775; -.
DR KEGG; lve:103077685; -.
DR KEGG; lve:103086775; -.
DR CTD; 50999; -.
DR OrthoDB; 601480at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR PANTHER; PTHR22811; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22811:SF41; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 5; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR SUPFAM; SSF101576; Supernatant protein factor (SPF), C-terminal domain; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003827};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022927}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..225
FT /note="Transmembrane emp24 domain-containing protein 5"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041070489"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..123
FT /note="GOLD"
FT /evidence="ECO:0000259|PROSITE:PS50866"
SQ SEQUENCE 225 AA; 25658 MW; 2E289BBBF086DF71 CRC64;
MGVKIWLPFP VVLLASQLLP GAAGFTPSLD SDFTFTLPAG QKECFYQPMP LKASLEIEYQ
VLDGAGLDID FHLASPKGRT LVFEQRKSDG VHTIETEGGD YMFCFDNTFS TISEKVIFFE
LILDNMGEQQ EQEDWKKYIT GTDMLDMKLE DILESINSIK SRLSKSGHIQ TLLRAFEARD
RNIQESNFDR VNFWSMVNLV VMVVVSAIQV YMLKSLFEDK RKSRT
//
