ID A0A340Y4X3_LIPVE Unreviewed; 1139 AA.
AC A0A340Y4X3;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN Name=TIE1 {ECO:0000313|RefSeq:XP_007468293.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007468293.1};
RN [1] {ECO:0000313|RefSeq:XP_007468293.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_007468293.1; XM_007468231.1.
DR AlphaFoldDB; A0A340Y4X3; -.
DR STRING; 118797.A0A340Y4X3; -.
DR GeneID; 103079731; -.
DR KEGG; lve:103079731; -.
DR CTD; 7075; -.
DR InParanoid; A0A340Y4X3; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00063; FN3; 3.
DR CDD; cd05089; PTKc_Tie1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR PANTHER; PTHR24416:SF341; TYROSINE-PROTEIN KINASE RECEPTOR TIE-1; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF00047; ig; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 2.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Kinase {ECO:0000313|RefSeq:XP_007468293.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_007468293.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT DOMAIN 226..257
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 317..346
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 447..544
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 546..643
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 647..740
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 840..1119
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 871
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT DISULFID 247..256
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 336..345
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1139 AA; 125202 MW; BEFEA3DD4CFA050E CRC64;
MVWLGPPLLL PIVFLASHVG AAVDLTLLAD LRLAEPQRFF LTCVSGEAGA GRGSDAWGSP
LLLEKDDRIV RTPRPWQPLH LARNGSRQVT LRGFSQPSDL VGVFSCVGGA GARRARVLYV
HNSPGAHLLP GKVTHTVNKG DTAVLSAWVR KEKQTDVIWK SNGSYFYTLD WHEAQEGRFL
LQLPNVQPSS SGIYSATYLE ASPLGSAFFR LIVRGCEAGH WGQDCTKECP GCLHGGVCHD
QDGECVCPPG FTGTRCEQAC REGRFGQSCQ EQCPGTSGCR GLTFCLPDPY GCSCGSGWRG
SQCQEACAPG HFGADCHLQC QCQNGGTCDR FSGCVCPSGW HGVHCEKSDR IPQILDMVSE
LEFNLETTPR INCAAAGNPF PVRGSVELRK PDGTVLLSTK AIVEPDRTTA EFEVPRLALG
DSGLWECRVS TSGGQDSRRF RVNVKVPPVP LTAPRLLAKQ SRQLMVSPLV SFSGDGPIAS
VRLHYRPQDS TMAWSTIVVD PSENVTLMNL RPKTGYSVRV QLSRPGEGGE GAWGPPTLMT
TDCPEPLLQP WLEGWHVEGP DRLRVSWSLP SVPGPLVGDG FLLRLWDGAR GQERRENVSS
PQARTALLTG LTPGTHYQLD VRLYHCTLLG PASPAARVLL PPSGPPAPRH LHAQALSDSE
IQLVWQRPEA PAGPISKYIV EVQVAEGSGD PLWMDVDRPE ETSTVVRGLN ASTRYLFRVR
ASVQGPGDWS DLVEESTLSN GLQSEGPVQE VQAAEEGLDQ QLVLAVVGSV SATCLTILAA
LLTLACIRRS CLHRRRTFTY QSGSGEETIL QFSSGTLTLT RRPKPQPEPL NYPVLEWEDI
TFEDLIGEGN FGQVIRAMIK KDGLKMNAAI KMLKEYASEN DHRDFAGELE VLCKLGHHPN
IINLLGACEN RGYLYIAIEY APYGNLLDFL RKSRVLETDP AFAREHGTAS TLSSRQLLRF
ASDAANGMQY LSEKQFIHRD LAARNVLVGE NLASKIADFG LSRGEEVYVK KTMGRLPVRW
MAIESLNYSV YTTKSDVWSF GVLLWEIVSL GGTPYCGMTC AELYEKLPQG YRMEQPRNCD
DEVYELMRQC WRDRPYERPP FAQIALQLGR MLEARKAYVN MSLFENFTYA GIDATAEEA
//
