ID A0A340Y6L2_LIPVE Unreviewed; 756 AA.
AC A0A340Y6L2;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Ras GTPase-activating protein 4 isoform X2 {ECO:0000313|RefSeq:XP_007468873.1};
GN Name=RASA4 {ECO:0000313|RefSeq:XP_007468873.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007468873.1};
RN [1] {ECO:0000313|RefSeq:XP_007468873.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007468873.1; XM_007468811.1.
DR AlphaFoldDB; A0A340Y6L2; -.
DR GeneID; 103086781; -.
DR CTD; 10156; -.
DR OrthoDB; 24454at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04054; C2A_Rasal1_RasA4; 1.
DR CDD; cd04025; C2B_RasA1_RasA4; 1.
DR CDD; cd05395; RasGAP_RASA4; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194:SF4; RAS GTPASE-ACTIVATING PROTEIN 4-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00616; RasGAP; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00432};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00432};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00432}.
FT DOMAIN 1..105
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 116..232
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 301..511
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 697..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 756 AA; 85225 MW; 3CFBC03B07748B33 CRC64;
MAKRSSLFIR IVEGKNLPAK DVTGSSDPYC IVKVDHEPII RTATVWKTLC PFWGEEYQVH
LLPTFHSVAF YVMDEDALSR DDVIGKVCLT RDTLATHPKG FSGWAHLTEV DPDEEVQGEI
HLRLEVVSGT RACRLRCSVL EARDLAPKDR NGASDPFVRV RYNGQMQETS IVKKSRYPRW
NETFEFELEE GAAEVLCVEA WDWDLVSRND FLGKVVFNVQ RLRAAQQEEG WFRLQPDQSK
SRREEGNLGS LQLEVRLRDE MVLPSGCYQP LVQLLCREVK MGTQSPGQLI LLIEETTSTE
CRQDVATTLL KLFLGQGLAK DFLDLLFQLE LGRTSEANTL FRSNSLASKS MESFLKVAGM
RYLHDVLGPI IDRVFEEKKY VELDPSKVEV KDVGCSGLHR PQTKAEVLEQ SAQTLRAHLG
ALLSSLSRSD RACPAVVRAT FRQLFRRVRE RFPSAQDENV PFIAVTSFLC LRFISPAIMA
PKLFHLRERH ADARTSRTLL LLAKAVQNVG NMDTPASRAK EAWMEPLQPT VRQGVAQLKD
FITKLVDIQE KEELDLQRAQ SLQAPPMKEG PLFIHRTKGK GPLMSSSFKK LHFSLTTEAL
SFAKTPSSKC VNELNQWLSA LRKVSINNTG LLGSYHPGVF RGDKWSCCHQ RDKTDLGCNK
TRSRVTLQEW NDPLDHDLEA QLIYRHLLGV EATLREKHRQ RGAGPEAGPV LTGPGAAPED
PLAQLLQVLQ DLREAHRSNP AGSPPLEPSR ILELQT
//
