ID   A0A340Y6P2_LIPVE        Unreviewed;       805 AA.
AC   A0A340Y6P2;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Transferrin receptor protein 2 {ECO:0000313|RefSeq:XP_007468908.1};
GN   Name=TFR2 {ECO:0000313|RefSeq:XP_007468908.1};
OS   Lipotes vexillifer (Yangtze river dolphin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Lipotidae; Lipotes.
OX   NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007468908.1};
RN   [1] {ECO:0000313|RefSeq:XP_007468908.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC       Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC       protein {ECO:0000256|ARBA:ARBA00004606}.
CC   -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC       {ECO:0000256|ARBA:ARBA00005634}.
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DR   RefSeq; XP_007468908.1; XM_007468846.1.
DR   AlphaFoldDB; A0A340Y6P2; -.
DR   STRING; 118797.A0A340Y6P2; -.
DR   GeneID; 103072633; -.
DR   KEGG; lve:103072633; -.
DR   CTD; 7036; -.
DR   InParanoid; A0A340Y6P2; -.
DR   OrthoDB; 2428249at2759; -.
DR   Proteomes; UP000265300; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004998; F:transferrin receptor activity; IEA:InterPro.
DR   GO; GO:0033572; P:transferrin transport; IEA:InterPro.
DR   CDD; cd09848; M28_TfR; 1.
DR   CDD; cd02128; PA_TfR; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR007484; Peptidase_M28.
DR   InterPro; IPR039373; Peptidase_M28B.
DR   InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR   InterPro; IPR037324; TfR1/2_PA.
DR   PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR   PANTHER; PTHR10404:SF33; TRANSFERRIN RECEPTOR PROTEIN 2; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF04389; Peptidase_M28; 1.
DR   SUPFAM; SSF52025; PA domain; 1.
DR   SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170,
KW   ECO:0000313|RefSeq:XP_007468908.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW   Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          242..306
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
FT   DOMAIN          412..610
FT                   /note="Peptidase M28"
FT                   /evidence="ECO:0000259|Pfam:PF04389"
FT   REGION          16..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   805 AA;  89013 MW;  E43375BB413AE1DB CRC64;
     MERLWGLLQR AQRLSPGPSQ TIYKRVEGTQ QGPLEEEEED REEGTEPPAH FFPMELRGPE
     PLGSRPARQN PRLWAAAGRR ATPYLVLTAL LIFTGAFLLG YVVFRGSCQA CGDDVMVVSE
     DMNHELGPDS HQGTLYWSDL QAMFLRHLGE GRLEDTIRQT SLRERVAGSA GMAALVQDLR
     AVLLSQKLDH VWMDTHYVGL QFPDPAHPNA LHWVDAAGKH GEQLPLEDPD VYCPYSATGN
     ATGELVYAHY GRPEDLQDLR ARGVEPKGRL LLVRLGVINF AQKVASAQDF GAQGVLIYPD
     PADFSQGPHK LSLSSHRAVY GHVHLGTGDP YTPGFPSFNQ TQFPPVQSSG LPSIPAQPIS
     ADTASLLLRK LEGPVAPQEW QGHLPVSPYR LGPGPGLHLG VNNHRASTPI SNIFGCIEGR
     SEPDHYVVIG AQRDAWGPGA ARSAVGTAIL LELVRTFSSM VSNGFRPRRS LLFISWDGGD
     FGSVGSMEWL EGYLSVLHLK AVVYVSLDNA VLGDDKFHAK TSPLLISLIE NILKQVDSPN
     RSGQTLFEQV VFNNHSWEAE VIRPLPMDSS AYSFTAFAGV PAVEFSFMED GPMYPFLHTK
     DDTYENLHRV LRGRLPAVAQ AVAQLAGQLL IRLSHDHLLP LDFGRYGDVV LRHIGSLTEF
     SGDLKARGLT LQWVYSARGD YIRAAEKLRK EIYSSEESDE RLTRMYNVRI MRVEFYFLSQ
     YVSAADSPFR HIFLGRGDHT LGALLDHVRL LRSSGPGALG EEAQVARGLG FQESRFRRQL
     ALLTWTLQGA ANALSGDVWN IDNNF
//