ID A0A340Y8F5_LIPVE Unreviewed; 832 AA.
AC A0A340Y8F5;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Zinc finger protein 746 {ECO:0000313|RefSeq:XP_007469941.1};
GN Name=ZNF746 {ECO:0000313|RefSeq:XP_007469941.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007469941.1};
RN [1] {ECO:0000313|RefSeq:XP_007469941.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007469941.1; XM_007469879.1.
DR AlphaFoldDB; A0A340Y8F5; -.
DR STRING; 118797.A0A340Y8F5; -.
DR GeneID; 103076964; -.
DR KEGG; lve:103076964; -.
DR CTD; 155061; -.
DR InParanoid; A0A340Y8F5; -.
DR OrthoDB; 4614113at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF145; ZINC FINGER PROTEIN 746-RELATED; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 299..370
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 656..676
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 698..725
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 726..753
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 754..782
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 39..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..105
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..802
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 832 AA; 89237 MW; E6ACE4E4DA76A0D1 CRC64;
MTNALEKSTH SAARSRPAEA SVCSRRLAAG SRLAAPSALA LPGAPSQTQP QFLASGTAGG
TRSPPTGCVA TLGGGGSGGG CDLGRRRRKP SRARRPLRRG GHGVSHPKRG GPASAALRAQ
ARTTLPRRRR GAGRRRGEVK AGRAWWAPSP RWFSRDPEKL PAGAWRRDLP GAPPSGLVAP
GRRPERRRFR WHRGPSACPA RSGSGRKTAA PISPWTMAAT IQAMERKIES QAARLLSLEG
RTGMAEKKLA DCEKTAVELG NQLEGKWAVL GTLLQEYGLL QRRLENVENL LRNRNFWILR
LPPGSKGEAP KEWGNLSEWQ KELYKHVMRG NYETLVSLDY AISKPEVLSQ IEQGKEPCSW
RRTGPKVPDV PVDPSPGSGP PVPAPDLLMQ IKQEGELQLQ EQQALGVEAW AAGQPDIGEE
PWGLSQLDSG AGDVSTDAAS GVHSNFSTTI PPTSWQADLP PHHPSSACSD GTLKLSTAAS
TEDVKIVIKT EVQEEEVVAT PVHPTDLEAH ATLFGPGQAT RFFPSPVQEG AWESQGSSFP
SQDPVLGLRE PARPERELGE PSPAVTQDET PPGDWLFGGV RWGWNFRCKP PAGLNPRTGP
EGLAYSSPDN GEAVLDPGQV PRPFSDPCKY PGRTKGFGHK PGLKKHPAAP PGGRPFTCAA
CGKSFQLQVS LSAHQRSCGG LPDGAPGAAG GARDGSGLRC GECGRCFTRP AHLIRHRMLH
TGERPFPCTE CEKRFTERSK LIDHYRTHTG VRPFTCTVCG KSFIRKDHLR KHQRNHAAGA
KPARGQPLPP LPAVPPDPFK SPASKGPLAS TDLVTDWTCG LSVLGPTDGG DL
//
