ID A0A340Y8J0_LIPVE Unreviewed; 895 AA.
AC A0A340Y8J0;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN Name=STAT2 {ECO:0000313|RefSeq:XP_007467780.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007467780.1};
RN [1] {ECO:0000313|RefSeq:XP_007467780.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR RefSeq; XP_007467780.1; XM_007467718.1.
DR AlphaFoldDB; A0A340Y8J0; -.
DR STRING; 118797.A0A340Y8J0; -.
DR GeneID; 103081732; -.
DR KEGG; lve:103081732; -.
DR CTD; 6773; -.
DR InParanoid; A0A340Y8J0; -.
DR OrthoDB; 7823at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0010033; P:response to organic substance; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd10373; SH2_STAT2; 1.
DR CDD; cd16846; STAT2_DBD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR022756; STAT2_C.
DR InterPro; IPR035854; STAT2_SH2.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF41; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12188; STAT2_C; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 572..650
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 788..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 895 AA; 101977 MW; BA217ECAE48166EA CRC64;
MAQWEMLQNL DSPFQDQLHQ LYSNSLLPVD IRQYLSVWIE DQNWQEAALG NDEAKANMLF
FHFLDQLNYE CSRCSQDPEC LLLQHNLRKF YRDIQAFPQG ATQLAEMIFN LLLEEKRILT
QAQRAQSEQG EPALAAPGES QQPEIESRIL ELKAMMEKLV KSISQLKDQQ DVFCFRYKIQ
TSARTPSLDP HQTRQQDILQ ETLNELDRRR KEVLDASKAL LGRLTTLIEL LLPKLEEWKV
QQQKACIGGP PDGGLEQLEK WFTAGSKLLF HLRQLLKELK GLSHMVTYQG DPLIEGVDLR
KAQVTELLHR LLHRAFVVET QPCMPQTPHR PLILKTGSKF TVRTRLLVRL QEGNESLTAE
VSIDRNPPES QGFRKFNILT SNRKTLTPEK GQSQGLIWDF GYLTLMEQRS GSSGKGSNKG
LLAVTEELHI ISFTVRYTYQ GLKQELKTDT LPVVIISNMN QLSVAWASVL WFNLLSSDPQ
NQQFFSSPAK APWDLLGPAL SWQFSSYVGR GLDSDQLGML RDKLFGQNSK TEGALLSWVN
FIKRESPPGK LPFWTWLDRI LDLVHDHLKD LWNDGHIMGF VSRSQERRLL KKTISGTFLL
RFSETLEGGI TCSWVEHQDD DKVLIYSVQP FTKEVLQSLP LTKIISQYQL LTEENIPENP
LCFLYPRIPR DEAFGCYSQE KVNLQERKKY LKHKLIVVSN RQVDELQQLP ELKLEPELES
FELDLGLAPG PEPGPGLDLE PLLEAGLDLG PALESTLEPT LEPVMESTLE PVLESALEPV
LESTLEPTLE STLEPVLEPT LGEVSQRVSE PNLGPGLKLE PIPEPISQPL PEPDLPHDLR
HLNIEDMEVF RNSMKIEEIM PNGDPLLAGQ NTVDEAYVFP RSHFYTDGPL IPSDY
//
