ID A0A340Y8L8_LIPVE Unreviewed; 1012 AA.
AC A0A340Y8L8;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=LOW QUALITY PROTEIN: toll-like receptor 12-like {ECO:0000313|RefSeq:XP_007468772.1};
GN Name=LOC103080092 {ECO:0000313|RefSeq:XP_007468772.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007468772.1};
RN [1] {ECO:0000313|RefSeq:XP_007468772.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR RefSeq; XP_007468772.1; XM_007468710.1.
DR STRING; 118797.A0A340Y8L8; -.
DR GeneID; 103080092; -.
DR KEGG; lve:103080092; -.
DR InParanoid; A0A340Y8L8; -.
DR OrthoDB; 1207361at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF522; TOLL-LIKE RECEPTOR 12; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF13676; TIR_2; 1.
DR SMART; SM00369; LRR_TYP; 5.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_007468772.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 859..1006
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1012 AA; 108628 MW; E9720314043E97B3 CRC64;
MTDPIQLDSG SKVPAAGLSG RGWGGGAEVR PDPWVSSHSA GGAEETQAAQ GHGLLRLGPL
RGRGSATRET ARVPVLQQLL RSLPQALASE LPRSPSLGCV PAPGRAAAGR SAGLGCSAST
ADPGSGRRRL PAGAHGNAPP RAARPGRDSW APKGLSRQSC GPSAPRAASP LRAGPSAHAP
ARYLRSRSRS SSTWPLSPGG RPSARPLGSA PRTLLATRPR PGEEGLTNLT QTLEAVPQSE
AGLCLSRSTS ILCLDAFSHF PGLKVLGLSL HLTQLLPGAR GSLGHSCSSS SSRPLYSLPL
PKLPPGLAFL GPCLDGNTGV QFSPSLRRLS VKYSRLQNVG ELADIFPDPV HGPSFGDAWL
LEXLDLSFNN QLKMASPGAL QGLKLGTLCL DHTKMRAAAV VGLGLQSLDT LSVINADTAK
LPAGAVAHFE LQELNLASTL VGHIALESLA SCHSLKSLGL KSSGLMTNLP PGFLEAMPSL
QKLNLSRNQL QXAMLGTNET GAVSRLRALD LSNNGLHTLS PVTFSCCPXL QELLLQGNQM
ICLQGQAFQG LRRLGKLDLA KNPLVDLGKG WLALLPAVTV LSLLDTRMVL SSALGFQGXL
HTLNLHLPSG PSGVVLSLPM SLTSLEFHAV SGRKPGMLAS NVFPVLQTLT LKGWGLQLGT
WNVTKIFPAL CQLSLLGDSL LXALCSQDTS NLFLWQLSRL WYQRVRGDGH SPKPCCMTGC
PXLWERKPQA LQSHAWPCSV LLEELLGELP RXQVLHLVKM GLETLSAAAF QGLGSLQVLE
LDWGTDLTLD GSLQEQSPQM PQYSKSPTYK QVLSRERLLL LISLPFLQEA RNSWILHLQA
LFRAWLQGPR SQRGEGRRFL YDVFVSHXRQ DQSRVTGELL PTLEGRPPMG RGLRFCLLEW
DFEPGKDVDD KVADGMAGSW VTLCVLSCQA LHTPCCCLDL CLATFLLLAA PTHPPGLLLV
FLELVSRHQL PCCSRLSWLL CRGDYCMWPK EDERKDEFWA WLRSRLGQPG LG
//