ID A0A340Y9U0_LIPVE Unreviewed; 1438 AA.
AC A0A340Y9U0;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Histone-lysine N-methyltransferase NSD3 isoform X2 {ECO:0000313|RefSeq:XP_007469848.1};
GN Name=WHSC1L1 {ECO:0000313|RefSeq:XP_007469848.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007469848.1};
RN [1] {ECO:0000313|RefSeq:XP_007469848.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_007469848.1; XM_007469786.1.
DR GeneID; 103072101; -.
DR CTD; 54904; -.
DR OrthoDB; 950362at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15649; PHD1_NSD3; 1.
DR CDD; cd15652; PHD2_NSD3; 1.
DR CDD; cd15658; PHD4_NSD3; 1.
DR CDD; cd15661; PHD5_NSD3; 1.
DR CDD; cd20163; PWWP_NSD3_rpt1; 1.
DR CDD; cd20166; PWWP_NSD3_rpt2; 1.
DR CDD; cd19212; SET_NSD3; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 4.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR041306; C5HCH.
DR InterPro; IPR047456; PHD2_NSD3.
DR InterPro; IPR047458; PHD4_NSD3.
DR InterPro; IPR047527; PHD5_NSD3.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR047451; PWWP_NSD3_rpt1.
DR InterPro; IPR047453; PWWP_NSD3_rpt2.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR047461; SET_NSD3.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22884:SF473; HISTONE-LYSINE N-METHYLTRANSFERASE NSD3; 1.
DR PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF17982; C5HCH; 1.
DR Pfam; PF00855; PWWP; 2.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00249; PHD; 4.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00293; PWWP; 2.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR SUPFAM; SSF82199; SET domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50812; PWWP; 2.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 270..333
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT DOMAIN 701..748
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 961..1023
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT DOMAIN 1094..1144
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 1146..1263
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1270..1286
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT DOMAIN 1322..1369
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 121..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1035..1062
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 124..142
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..604
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1438 AA; 161770 MW; F0AEEAAB47DFED5F CRC64;
MDFSFSFMQG IMGNTIQQPP QLIDSANIRQ EDAFDNNSDI VEDGGQTPYE ATLQQGFQYP
PTTEDLPPLT NGYPSSISMY ETQTKYQSYN QYPNGSANGF GAVRNFSPTD YYHSEIPNTR
PHEILEKPSP PQPPPPPSVP QTVIPKKTGS PEIKLKITKT IQNGRELFES SLCGDLLNEV
QASEHTKSKH ESRKEKRKKS NKHDSSRSEE RKSHKIPKLE PEEQNRPNER VDTLSEKPRE
DPVLKEELPV QPMLPSVPTT EVSTGVKFQV GDLVWSKVGT YPWWPCMVSS DPQLEVHTKI
NTRGAREYHV QFFSNQPERA WVHEKRVREY KGHKQYEELL AEATRQASNH SEKQKIRKPR
PQRERAQWDI GIAHAEKALK MTREERIEQY TFIYIDKQPE EALSQAKKNV ASKAEVKKTR
RPRSVLNTQP EQTSASEAAS SLSGTEIRRH SQRRHTSVEE DEPPPVKVAW KTAAARKSLP
ASITMHKGSL DLQKCNMSPV VKIEQVFALQ NATGDGKFID QFVYSTKGIG NKTEISVRGQ
DRLIISTPNQ RNEKATQNMS SPETTSGPAG SVEKKQQRRS IRTRSESEKS TEVVPKKKIK
KEQVETVPQA TVKTGLQKGA SEISDSCKPL KKRSRASTDV EMASSTYRDT SDSDSRGLSD
LQVGFGKQVD SPSATADADV SDVQSVDSSL SRRGTGMSRK DTVCQICESS GDSLIPCEGE
CCKHFHLECL GLTSFPDGKF ICVECKTGEH PCFSCKVSGT DVKRCSVGAC GKFYHEACVR
KFPTAIFESK GFRCPQHCCS ACCMEKDIHK ASKGRMMRCL RCPVAYHSGD ACIAAGSIFV
SSYVLICSNH SKRSSNSSSA VNVGFCFVCA RGLIVQDHSD PMFSSYAYKS HYLLNESNRA
ELMKLPMIPS SSASKKKCEK GGRLLCCESC PASFHPECLS IEMPEGCWNC NDCKAGKKLH
YKQIVWVKLG NYRWWPAEIC NPRSVPLNIQ GLKHDLGDFP VFFFGSHDYY WVHQGRVFPY
VEGDKSFAEG QTSINKTFKK ALEEAAKRFQ ELKAQRESKE ALEIEKNSRK PPPYKHIKAN
KVIGKVQIQV ADLSEIPRCN CKPADENPCG LESECLNRML QYECHPQVCP AGERCQNQCF
TKRLYPDAEI IKTERRGWGL RTKRSIKKGE FVNEYVGELI DEEECRLRIK RAHENSVTNF
YMLTVTKDRI IDAGPKGNYS RFMNHSCNPN CETQKWTVNG DVRVGLFALC DIPAGMELTF
NYNLDCLGNG RTECHCGADN CSGFLGVRPK SACASTTEEK AKNAKLKQKR RKIKTEPKQL
HEDHCFQCGD SGELVMCDRK DCPKAYHLLC LNLPQPPYGK WECPWHQCDE CSGAAVSFCE
FCPRSFCKDH EKGALVPSAL EGRLCCSEHD PVSPVSPEYW SKIKCKLESQ DHGEEVKE
//
