ID A0A340YBS2_LIPVE Unreviewed; 936 AA.
AC A0A340YBS2;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=VPS10 domain-containing receptor SorCS1-like isoform X2 {ECO:0000313|RefSeq:XP_007470513.1};
GN Name=SORCS1 {ECO:0000313|RefSeq:XP_007470513.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007470513.1};
RN [1] {ECO:0000313|RefSeq:XP_007470513.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR RefSeq; XP_007470513.1; XM_007470451.1.
DR AlphaFoldDB; A0A340YBS2; -.
DR GeneID; 103089679; -.
DR CTD; 114815; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_007470513.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 859..877
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 593..637
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 899..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 936 AA; 105614 MW; CDCA56F6F6CAAD21 CRC64;
MLLTDPEIES SLLISSDEGA TYQKYRLNFY IQSLLFHPKQ EDWILAYSQD QKLYSSAEFG
RRWQLIQEGV IPNRFYWSVM GSNKEPDLVH LEARTVDGHS QYLTCRMQNC TEASRNKPFP
GYIDPDSLIV QDDYVFVQLT SGGRPHYYVS YRRNAFAQMK LPKYALPKDM HVISTDENQV
FAAVQEWNQN DTYNLYISDT RGVYFTLALE NVQSSRGPEG NVMIDLYEVA GIKGMFLANK
KIDNQVKTFI TYNKGRDWHL LQAPDTDLRG DPVHCLLPYC SLHLHLKVSE NPYTSGIIAS
RDTAPSIIVA SGNIGSELSD SDISMFVSSD AGNTWRQIFE EEHSVLYLDQ GGVLVAMKHT
SLPIRHLWLS FDEGRSWSKY SFTSIPLFVD GVLGEPGEET LIMTVFGHFS HRSEWQLVKV
DYKSIFDRRC AEEDYRPWQL HSQGEACIMG AKRIYKKRKS ERKCMQGKYA GAMESEPCVC
TEADFDCDYG YERHSNGQCL PAFWFNPSSL SKDCSLGQSY LNSTGYRKVV SNNCTDGVRE
QYTAKPQKCP GKAPRGLRIV TADGKLTAEQ GHNVTLVVQL EEGDVQRTFI QVDFGDGIAV
SYVNLSSMED GIKHVYHNVG IFRVTVQVDN SLGSDSAVLY LHVTCPLEHV HLSLPFVTTK
NKEVNATAVL WPSQVGTLTY VWWYGNNTEP LITLEGSISF KFTSEGMNTI TVQVSAGNAI
LQDTKTIAVY EEFRSLRLSF SPNLDDYNPD IPEWRRDISR VIKKSLVEAT AVPGQHILVA
VLPGLPTAAE LFVLPYQDPT GENKRSAEDL EQISELLIHK LNLNSVHFEL KPGVQVLVHA
AHLTAAPLVD LTPTHSGSAM LMLLSVVFVG LAVFVIYKFK RKIPGINVYA QMQNEKEQEM
VSQVSHPESR PRIPQTELRR PGQLIDEKVE SQLIGE
//
