ID   A0A340YBY3_LIPVE        Unreviewed;       491 AA.
AC   A0A340YBY3;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=proline--tRNA ligase {ECO:0000256|ARBA:ARBA00012831};
DE            EC=6.1.1.15 {ECO:0000256|ARBA:ARBA00012831};
DE   AltName: Full=Prolyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00029731};
GN   Name=PARS2 {ECO:0000313|RefSeq:XP_007471201.1};
OS   Lipotes vexillifer (Yangtze river dolphin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Lipotidae; Lipotes.
OX   NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007471201.1};
RN   [1] {ECO:0000313|RefSeq:XP_007471201.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-
CC         tRNA(Pro); Xref=Rhea:RHEA:14305, Rhea:RHEA-COMP:9700, Rhea:RHEA-
CC         COMP:9702, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:60039,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78532, ChEBI:CHEBI:456215;
CC         EC=6.1.1.15; Evidence={ECO:0000256|ARBA:ARBA00000857};
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DR   RefSeq; XP_007471201.1; XM_007471139.1.
DR   AlphaFoldDB; A0A340YBY3; -.
DR   STRING; 118797.A0A340YBY3; -.
DR   GeneID; 103074858; -.
DR   KEGG; lve:103074858; -.
DR   CTD; 25973; -.
DR   InParanoid; A0A340YBY3; -.
DR   OrthoDB; 65716at2759; -.
DR   Proteomes; UP000265300; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004827; F:proline-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006433; P:prolyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd00779; ProRS_core_prok; 1.
DR   Gene3D; 3.40.50.800; Anticodon-binding domain; 1.
DR   InterPro; IPR002314; aa-tRNA-synt_IIb.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR004154; Anticodon-bd.
DR   InterPro; IPR036621; Anticodon-bd_dom_sf.
DR   InterPro; IPR002316; Pro-tRNA-ligase_IIa.
DR   InterPro; IPR033730; ProRS_core_prok.
DR   PANTHER; PTHR42753; MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR42753:SF2; PROLINE--TRNA LIGASE, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF03129; HGTP_anticodon; 1.
DR   Pfam; PF00587; tRNA-synt_2b; 1.
DR   PRINTS; PR01046; TRNASYNTHPRO.
DR   SUPFAM; SSF52954; Class II aaRS ABD-related; 1.
DR   SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   4: Predicted;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|RefSeq:XP_007471201.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..491
FT                   /note="proline--tRNA ligase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016253972"
FT   DOMAIN          70..385
FT                   /note="Aminoacyl-transfer RNA synthetases class-II family
FT                   profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50862"
SQ   SEQUENCE   491 AA;  54618 MW;  9056A7E0B9ACE24C CRC64;
     MHWCLHSASA SLRWGVMEGL LTRCRALPAL ATSSHQLSGY VPHRFHHRAP GRGKRLVLSR
     MFQPQNLRED QVLSLEGRSG ELTCKSQRLM LQVGLIHPAS SGCYHLLPYT VRAMEKLVRV
     IDQEMQAIGG QKVNMPSLSP AELWRATSRW DSMGKELLKL RDRHGKEYCL GPTHEEAITA
     LIASQQTLSY KQLPLLLYQV TRKFRDEPRP RFGLLRGREF YMKDMYTFDS SPEAAQQTYS
     LVCDAYSSLF DRLGLQCVKV QADVGSIGGT TSHEFQLLVD VGEDRLAVCP GCGFSANMET
     LDLSQTNCPA CQGPLTKTKG IEVGHTFYLG TKYSSIFSAQ FTNVHGKPSL AEMGCYGLGV
     TRILAAVIEA LATEDCIRWP GLLAPYQVCL VSPKKGSKEE AAAELTGHLY DHITEAVPQL
     RGEVLLDDRT HLTIGNRLKD ANKFGYPFVI IAGKRALDDP AQFEVWCQNT GEVVFLTREG
     VLELLSQVQV V
//