ID A0A340YC68_LIPVE Unreviewed; 1466 AA.
AC A0A340YC68;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 2 {ECO:0000313|RefSeq:XP_007470032.1};
GN Name=FARP2 {ECO:0000313|RefSeq:XP_007470032.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007470032.1};
RN [1] {ECO:0000313|RefSeq:XP_007470032.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007470032.1; XM_007469970.1.
DR STRING; 118797.A0A340YC68; -.
DR GeneID; 103088800; -.
DR KEGG; lve:103088800; -.
DR CTD; 9855; -.
DR InParanoid; A0A340YC68; -.
DR OrthoDB; 2876516at2759; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17190; FERM_F1_FARP2; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 2.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 2.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300}.
FT DOMAIN 46..326
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 842..932
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1106..1155
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1184..1281
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1357..1454
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 420..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 767..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1037..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1292..1334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..563
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1466 AA; 161300 MW; 9F61F71F59098412 CRC64;
MGELEGTYRV LQTPGTRLGA PTPAGVSTLE PGQGPSAAAA WPAARTPIRV QLLDSSVEVF
DVEPKRDGQV LLTQVWKRLN LIECDYFGLE FQNVQSCWIW LEPMKPIVRQ VRRPKNSVLR
LAVKFFPPDP GQLQEEYTRY LFALQLKRDL LEERLTCTDT TAALLASHLL QAEIGDYEEA
LVREHLQAHE YLPGQERALE RILELHRGHA GQTPAESDFQ VLEIARKLEM YGIRFHTASD
REGAKINLAV SHMGILVFQS STKINTFNWS RLRKLSFKRK RFLIKLHPEV HGPYQDTLEF
VLGSRDACKN FWKTCVEYHT FFRLSDQPKP RARAVLFSRG SSFRYSGRTQ KQLVDYVKDG
GMKGIPYERK HSKTRMSLRA LNANLPRQHL VHRGHEDSRV PVFNKCLLLF GPRLLSSPHG
PARFQGQQRL PDGAPGSQRQ VASCREERSG RSPTPRAACI PALPRGAPTC GLQSLRGGPV
FTLTSTQLPA FEEFRDGGLA DISFFAGGSE AFPFPFGSLR PQALLCGRLG SAPSSPEGSS
PEPARGSGAR GFESEEEGSL GDAHPADTSE LLEVKAQASL MQRLLSPSAA SSLRLHRSET
SSLSNAPLPG SLSAHTPGSA AQSEASSMAN FPACSVRSEA SSAFHFSDII DQLEQLSCPP
TTAEDPSGSD TDSWGSEAEA PLDVSLFFGP SWLRSRDVHT RRPRTSQATG PSALVLTGQR
LWRDCVTMTD VTKVSLYAIP GYTGTRRTLE CDPEQLRREA SVFCSQGSRA SGTAQRHPEP
SVGLSVESPQ LPSTRKTPPS LSPLGPAEQG SSPLLNPVLS DAGGAGTDDQ EELRHKCAPA
DEAYFIAKEI LATERTYLKD LEVITVWFRS AVVKADAMPA DLMTLVFSNI DPIYEFHRGF
LREVEQRLAL WEGSSSAQAT GDHRRIGDVL LSNMLQLKVA RVKRGVPRGR RTGQPALRSE
RYFHGDSPSS GRAPLRAGPL RAALRAAQRW PALSSRHALL RIKRALPGLR PAGPGSPQSR
GPVQLLLLSA RPFPASPAGL GAPGGGAGRA SSARRSRGTG TDGVGAASSS PRLPAEAPPP
RPPVLGAEER GVNFGPTRTR GRRGPPLQRL RHYRLLLRRL CASDRQDPDR GDQDRAERRE
ALKAITEVTS TLQHSLVRLE NLQKLMELQR DLVGIENLIA PGREFIREGC LHKLTRKGLQ
QRMFFLFSDM LLYTSRGASG TSHFRIRGLL PLRSMLVEER ENEWPVPHCF TIYAAQKTVV
VAASTQLEKE KWMRDLNAAI DAAKSSADTA LAPLGSQGLT SPPGPSDEVS LEESEDDARR
ARCSSGGPGQ HRASTTMHVC WDRTTSISRA DCSAAVENQL SGYLLRKVKN SGGWQKLWVV
LTNFCLFFYK THQDDCPLAS LPLLGYSVSL PGEADGIHKE HVFKLQFKSH VYFFRAESKY
TLGRWMEVIE SASTSPGRAR TPEEEA
//
