ID A0A340YG03_LIPVE Unreviewed; 631 AA.
AC A0A340YG03;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 {ECO:0000313|RefSeq:XP_007470380.1};
GN Name=PAPSS2 {ECO:0000313|RefSeq:XP_007470380.1};
OS Lipotes vexillifer (Yangtze river dolphin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Lipotidae; Lipotes.
OX NCBI_TaxID=118797 {ECO:0000313|Proteomes:UP000265300, ECO:0000313|RefSeq:XP_007470380.1};
RN [1] {ECO:0000313|RefSeq:XP_007470380.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Sulfur metabolism; sulfate assimilation.
CC {ECO:0000256|ARBA:ARBA00005050}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the sulfate
CC adenylyltransferase family. {ECO:0000256|ARBA:ARBA00009290}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the APS kinase
CC family. {ECO:0000256|ARBA:ARBA00007268}.
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DR RefSeq; XP_007470380.1; XM_007470318.1.
DR AlphaFoldDB; A0A340YG03; -.
DR STRING; 118797.A0A340YG03; -.
DR GeneID; 103079281; -.
DR KEGG; lve:103079281; -.
DR CTD; 9060; -.
DR InParanoid; A0A340YG03; -.
DR OrthoDB; 22780at2759; -.
DR UniPathway; UPA00097; -.
DR Proteomes; UP000265300; Unplaced.
DR GO; GO:0004020; F:adenylylsulfate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004781; F:sulfate adenylyltransferase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0000103; P:sulfate assimilation; IEA:UniProtKB-UniPathway.
DR CDD; cd02027; APSK; 1.
DR CDD; cd00517; ATPS; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.10.400.10; Sulfate adenylyltransferase; 1.
DR HAMAP; MF_00065; Adenylyl_sulf_kinase; 1.
DR InterPro; IPR002891; APS_kinase.
DR InterPro; IPR025980; ATP-Sase_PUA-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR024951; Sulfurylase_cat_dom.
DR InterPro; IPR002650; Sulphate_adenylyltransferase.
DR NCBIfam; TIGR00455; apsK; 1.
DR PANTHER; PTHR11055; BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE; 1.
DR PANTHER; PTHR11055:SF16; BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2; 1.
DR Pfam; PF01583; APS_kinase; 1.
DR Pfam; PF01747; ATP-sulfurylase; 2.
DR Pfam; PF14306; PUA_2; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000265300};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 273..437
FT /note="ATP-sulfurylase PUA-like"
FT /evidence="ECO:0000259|Pfam:PF14306"
FT DOMAIN 445..576
FT /note="Sulphate adenylyltransferase catalytic"
FT /evidence="ECO:0000259|Pfam:PF01747"
FT DOMAIN 581..622
FT /note="Sulphate adenylyltransferase catalytic"
FT /evidence="ECO:0000259|Pfam:PF01747"
SQ SEQUENCE 631 AA; 71494 MW; 5C96F1FE5EE6A747 CRC64;
MGYVIERRQF VIQVVVVKNN AEVCWIFGVM TGENTEETCT SPQRTDNPYP GRQLIHFASC
SGTYGETQQK STNVVYQAHH VSRNKRGQVV GTRGGFRGCT VWLTGLSGAG KTTISFALEE
NLVSHAIPCY SLDGDNVRHG LNKNLGFSPW DREENIRRIA EVARLFADAG LVCITSFISP
FAKDRENARK IHESAGLPFF EIFVDAPLNI CESRDVKGLY KRARAGEIKG FTGIDSDYEK
PETPELVLKT NLSSVSDCVQ QVVELLQEQN IVPHTIIKGI HELFVPENKL DQVRAEAEVL
PSLSITKLDL QWVQVLSEGW ATPLKGFMRE KEYLQVIHFG TLLDGMFLPD GVINMSIPVV
LPVSVDDKTR LEGCSEFVLT HGGRKVAILR DPEFYEHRKE ERCSHVWGTT CAKHPYIKMV
MESGDWLVGG DLQVLERIRW NDGLDQYRLT PLELKQKCKE MNADAVFAFQ LRNPVHNGHA
LLMQDTRRRL LERGYKHPVL LLHPLGGWTK DDDVPLDWRM KQHTAVLEEE VLDPKSTIVA
IFPSPMLYAG PTEVQWHCRS RMVAGANFYI VGRDPSTHHA QSSHKHNEFD FISGTRMRKL
AREGENPPDG FMAPKAWKVL TDYYRSLEKN N
//
