ID A0A341AV31_NEOAA Unreviewed; 2130 AA.
AC A0A341AV31;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Polycystic kidney disease and receptor for egg jelly-related protein {ECO:0000313|RefSeq:XP_024593167.1};
GN Name=PKDREJ {ECO:0000313|RefSeq:XP_024593167.1};
OS Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
OS (Neophocaena phocaenoides subsp. asiaeorientalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Phocoenidae; Neophocaena.
OX NCBI_TaxID=1706337 {ECO:0000313|Proteomes:UP000252040, ECO:0000313|RefSeq:XP_024593167.1};
RN [1] {ECO:0000313|RefSeq:XP_024593167.1}
RP IDENTIFICATION.
RC TISSUE=Meat {ECO:0000313|RefSeq:XP_024593167.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_024593167.1; XM_024737399.1.
DR STRING; 1706337.A0A341AV31; -.
DR KEGG; nasi:112394607; -.
DR InParanoid; A0A341AV31; -.
DR OrthoDB; 52189at2759; -.
DR Proteomes; UP000252040; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR10877:SF150; POLYCYSTIC KIDNEY DISEASE AND RECEPTOR FOR EGG JELLY-RELATED PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_024593167.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000252040};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..2130
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016442496"
FT TRANSMEM 1060..1080
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1265..1283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1303..1325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1452..1475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1487..1509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1584..1608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1842..1862
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1874..1894
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1914..1940
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1961..1988
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2023..2049
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 86..785
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 1105..1222
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 1360..1439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1360..1377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1396..1410
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1411..1433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2130 AA; 242094 MW; F6311D9367035B89 CRC64;
MRPGPVLLLL GLGLGLSLSA ARVSPRSAVS PLSALPRGPR SYAGLVARTK CPTDGPTPVV
LEAVNPNSSQ AMESSVSCQI SRSGVCVLDL VRIERNDDSP LQLTRKMEVT INATVKVHCP
IQRFFGQYWK LYSVASVSDK PDWTKPLQNP PFKSENTPSS IRISTHSLSW GVYLLNFSVY
IVTHDPKIPL KKDSDSIYII IVKSPLQAVI PGDTNITVNF TDGLTLNGNM SSDPDAENPL
EGLQFFWYCT TDPRNYDGHE ITVRSKEVCL PEQVDLRWTW ASGPILTLLP ETLHGGRVYF
FRLVIQKNDR TAFSDRVVHV LQGPAPVASI SCIENCDTVL IISERFSLSL ECPRCKAGRD
VYRWSILSSS GDKMPFDWTG QTTTGRNGAY LSVKAFAFRR FVEDKFWISL NLATWGGSSL
VLRHPFVIHH VPETTECKID PAEGIAFITK FVVHCCSFKD KNIVLTYKII VPDVHGFGEI
SSLKENNFGS ILYWGKDCTA PPSFLPVGVL ANHYALKIHA QAYNTSLGAF SQVTLYATVQ
APTDINSSRT VLQELFSSTV GPDSSLSTLL QQQDFLPAGY LMYIVASVLN SMKTDSHLQA
DQIRLREHLF NQSFILPVNT VVEISQVVMT VTKLTQKTSE FSSLAQKLAT VRTWQASQAL
QECHRRDKHI SSEQIETVST GILTSLSNIL KLMVRHEVVE EPFHVVESLA ETVLAVKVPE
DKTTAMRTSN FNMYVKKTEK WNVTKFFSTE KHCRNCFYPT LNVSSVPSLP ANAPISTMFC
EFADDPFPWL NYGENILTEV VGFRMTGTEA TGDVIEITPD VVEVYLVRKN LSFGTFNLTV
GPSKESPKVN ESLRKTTGAF SFNVDSRAGK EVLIHIVTEV AVLFTVLVYA GHQITPTALI
ATYLVPHRIP PVAQDSDLFD PDCTVTEARV VCLPPSLLRV IAQRTSSSEP TVTVVLQAPH
FVLEPNDKLV RISVFSTQCL DMYGIQSDWR EDTCVVGEKT TWRKVHCICK NPGRARRQLD
AMKLANLHLH THYLAAKVIV VPNPVDLRLE VIRNVTQNPV TLFTVLFIML LYIVLGFWAL
HRDEMDKCLR ERVVVLPDND PYDKVCYLVT IFTGSRCGSG TRADVFVQLQ GTESSSDVHC
LSHPQFTTLY RGSISTFLLT TKNDLGDIHS IRVWHNNEGS SPSWYLSRIK VENLFTRHIW
LFMCREWLSI DTSLDRTFQV TPPDKSLKRM DFFLTDLSYR LGRSHMWFSV FSGVIATPFS
RLQRLSCCLA MLLSSLLCNI MFFNLNKEKE AESQEEKYLR SMVIGMESVL ITIPLQLMIT
SLFIYSQRRP PVTLREVAPR KHPGTPAASK HWEERLAKWH AQETGNERSR EPEKLPPTRR
SPGLPKASVK TTSKRRPQPK RAESKVSRTQ RKNKNANNPN VEDNRSVSPG EHPRQPNATP
LKEKTRIVLP RCCVYVAWLL VFVTCTISSF FIVFYGLTYG YKKSIEWLFA SFCCFLQSVF
LVQPSKIIVV SGYRTSKPKY CKNLLWVGPC RYSEIELQNI TQNPEEMRRR RQHIVQLRSS
RMYQPPTEDD ITIFKRKKRI KRRAFLFLSY ILTHFVFLAL LLSLVTLLHH TDGFYYNRFI
RDQFSVDLAS VTKPEDIYRW LNSVLLPLLH NDLRPTFLPE SSSKILGLPL MRQVRARPGE
KTCLPAKHFT QDSLKREIHC HPEYGTDPED TKSYSGLWNR VSKRAIDKTT KGFTYKPREK
RWVYHSYGLL HTYGSGGYAF YFFPEEQQFN STLRLSELQG SRWLDEKTWA VILELTTFNP
DTALFCSVSV IFEVSRVGVV NASLSAHSFS LADLNRKTSA EIYLYVAILI FFFAYVVEEV
YVITQERSAY VKSVYNLLNF ALKCIFTVLI VLFFRKHFLA VGIIRFYLSN SEDFIPFHAV
SQVDHAMRVI LGFLLFLTNL KTLRYSRFFY HVRLAQRAIQ TALPGICHMA LVVSVYLFVY
MTFGYLAFGQ HEWNYSDMTR ATQTVFSYCV SALQNTEFSS NRVLGVLFLS SFLLVMMCIW
INLLQAVILS AYGEMKQPVY EEPSEEAEAM TYLCHRLRTA FGFLSFKSKA EDQPNFFVNM
VYGQPEKNDS RYLGLKTRNI NGKKTVYLVV
//
