ID A0A341BKC6_NEOAA Unreviewed; 1149 AA.
AC A0A341BKC6;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Solute carrier family 12 member 3 isoform X3 {ECO:0000313|RefSeq:XP_024603190.1};
GN Name=SLC12A3 {ECO:0000313|RefSeq:XP_024603190.1};
OS Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
OS (Neophocaena phocaenoides subsp. asiaeorientalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Phocoenidae; Neophocaena.
OX NCBI_TaxID=1706337 {ECO:0000313|Proteomes:UP000252040, ECO:0000313|RefSeq:XP_024603190.1};
RN [1] {ECO:0000313|RefSeq:XP_024603190.1}
RP IDENTIFICATION.
RC TISSUE=Meat {ECO:0000313|RefSeq:XP_024603190.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR RefSeq; XP_024603190.1; XM_024747422.1.
DR AlphaFoldDB; A0A341BKC6; -.
DR Proteomes; UP000252040; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IEA:UniProt.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002948; SLC12A3.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF9; SOLUTE CARRIER FAMILY 12 MEMBER 3; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01230; NACLTRNSPORT.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000252040};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 167..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 508..526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 569..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..116
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 140..684
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 693..827
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 863..1023
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1075..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1149 AA; 126441 MW; D7C6FD77A5EAEA01 CRC64;
MAELPVSEMP RDPALCSGRF TISTLLGGDE PPPPAAYDSS HPSHLTHGST FYMRTFGYNT
IDVVPAYEHY ANSTLPGEPR KVRPTLADLH SFLKQEGSHL HALAFDSRPS HEMTDGLVED
EAGTNSENPE EPVRFGWVKG VMIRCMLNIW GVILYLRLPW ITAQAGIVLT WIIILLSVMV
TSITGLSISA ISTNGKVKSG GTYFLISRSL GPELGGSIGL IFAFANAVGV AMHTVGFAET
VQDLLQEYGS PIVDPTNDIR IIGVVTVTVL LAISLAGMEW ESKAQVLFFL VIMVSFANYL
VGTLIPPSED KASKGFFSYR ADIFAQNLVP DWRGVDGSFF GMFSIFFPSA TGILAGANIS
GDLKDPAVAI PKGTLMAIFW TTISYLAISA TIGSCVVRDA SGILNDTVTP GSGACEGLAC
GYGWNFTECS QQHSCRYGLI NHYQTMSMVS GFAPLITAGI FGATLSSALA CLVSAAKVFQ
CLCIDQLYPL IGFFGKGYGK NNEPVRGYLL AYAIAVAFII IAGTSLPRSE LAPRSTLGAQ
DKLTDSSSGA GTNSWITISV AELNTIAPII SNFFLCSYAL INFSCFHASI TNSPGWRPSF
RYYSKWAALF GAIISVVIMF LLTWWAALIA IGVVLFLLLY VIYKKPEVNW GSSVQAGSYN
LALSYSVGLN EVEDHIKNYR PQCLVLTGPP NFRPALVDFV GTFTRNLSLM VCGHVLIGPR
KQRMPELRLI ANGHTKWLNK RKIKAFYSDV IAEDLRSGVQ ILMQAAGLGR MKPNILVVGF
KKNWQSAHPA TVEDYIGILH DAFDFNYSVC VMRMREGLNV SKVMQAHINP VFDPAEDGKE
ARASGARLSV SGTVEPEGLV QEEQASTIFQ SEQGKKTIDI YWLFDDGGLT LLIPYLLGRK
KRWNKCRTRV FVGGQINRLD QERKAIISLL SKFRLGFHEV HILPDINQKP QAEHTKRFED
MIAPFRLNDG FKDEATVTEM RRDCPWKISD EEINKNRVKS LRQVRLNEIL LDYSQDAALV
IMEFIQLEKG HGGHHCHFPE LIPQGRKGNQ QKHQEEGPLL REPERLAELL KDGEGAASEP
FSGPGPTLTP DKAKAPSGNA CLSRAAWKTI SWQTGAPSSD LRESLIQEQR MLCLWELKNK
KFTVLETKF
//
