ID A0A341C5D6_NEOAA Unreviewed; 883 AA.
AC A0A341C5D6;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN Name=OTUD7A {ECO:0000313|RefSeq:XP_024610060.1};
OS Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
OS (Neophocaena phocaenoides subsp. asiaeorientalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Phocoenidae; Neophocaena.
OX NCBI_TaxID=1706337 {ECO:0000313|Proteomes:UP000252040, ECO:0000313|RefSeq:XP_024610060.1};
RN [1] {ECO:0000313|RefSeq:XP_024610060.1}
RP IDENTIFICATION.
RC TISSUE=Meat {ECO:0000313|RefSeq:XP_024610060.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C64 family.
CC {ECO:0000256|ARBA:ARBA00005865}.
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DR RefSeq; XP_024610060.1; XM_024754292.1.
DR AlphaFoldDB; A0A341C5D6; -.
DR STRING; 1706337.A0A341C5D6; -.
DR KEGG; nasi:112405765; -.
DR InParanoid; A0A341C5D6; -.
DR OrthoDB; 2909231at2759; -.
DR Proteomes; UP000252040; Unplaced.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd14347; UBA_Cezanne_like; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR003323; OTU_dom.
DR PANTHER; PTHR13367:SF9; OTU DOMAIN-CONTAINING PROTEIN 7A; 1.
DR PANTHER; PTHR13367; UBIQUITIN THIOESTERASE; 1.
DR Pfam; PF02338; OTU; 1.
DR PROSITE; PS50802; OTU; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000252040};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 200..382
FT /note="OTU"
FT /evidence="ECO:0000259|PROSITE:PS50802"
FT REGION 77..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 883 AA; 96190 MW; 7386830CA42DADC3 CRC64;
MVSSLLPNPT SAECWAALLH DPMTLDMDAV LSDFVRSTGA EPGLARDLLE GKNWDLTAAL
SDYEQLRQVH TANLPPVFNE GRCPKQPERE HPPPAHTAER PCLPRQDDIA QEKRLSRGIS
HASSAIVSLA RSHVASECSS EQFPLEMPIY TFQLPDLSVY SEDFRSFVER DLIEQATMVA
LEQAGRLNWW STVCTSCKRL LPLATTGDGN CLLHAASLGM WGFHDRDLVL RKALYTMMRT
GAEREALKRR WRWQQTQQNK ESGLVYTEEE WEREWTELLK LASSEPRTHI SKHGGSGGGM
DNAEDPVYES LEEFHVFVLA HILRRPIVVV ADTMLRDSGG EAFAPIPFGG IYLPLEVPPN
RCHCSPLVLA YDQAHFSALV SMEQRDQQRE QAVIPLTDSE HKLLPLHFAV DPGKDWEWGK
DDNDNARLAH LILSLEAKLN LLHSYMNVTW IRIPSETRAP LAQPESPTAS AGEDVQSLPD
SLDSDRDSVC SNSNSNNGKN GKDKEKEKQR KDKDKTRADS VANKLGSFSK TLGIKLKKNM
GGLGGLVHGK MSRANPANGK HSDPPERGKE KKAKARKGSK EESGASASTS PSEKTTPSPT
DKTAGASPAD KGGGPRGDAW KYSTDVKLSL NILRAAMQGE RKFIFAGLLL TSHRHQFHEE
MIGYYLTSAQ ERFSAEQEQR RRDAAAAATS TANRPLRLGC PLHAVGVSSA PWSTGRPAIL
CPCCGFEANA RPRDRGGGSA SGSHLCPSRV PGGQGVPGSS DIHTAIKVAG VCRMGTGQPT
SQGADAWRLQ GALRGTLIRK TFTIAPSNVR DGLFAVMEAG AICMRTSIVG SSVVFCRASA
SCAVAGKQDE SQAPPDMSKL LLVVLADAQG EPKPPISAHA VEQ
//
