ID A0A344L5X9_9PSEU Unreviewed; 424 AA.
AC A0A344L5X9;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN ORFNames=A4R43_13610 {ECO:0000313|EMBL:AXB43453.1};
OS Amycolatopsis albispora.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis.
OX NCBI_TaxID=1804986 {ECO:0000313|EMBL:AXB43453.1, ECO:0000313|Proteomes:UP000250434};
RN [1] {ECO:0000313|EMBL:AXB43453.1, ECO:0000313|Proteomes:UP000250434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WP1 {ECO:0000313|EMBL:AXB43453.1,
RC ECO:0000313|Proteomes:UP000250434};
RA Wang H., Chen S., Wu Q.;
RT "Complete genome sequence and analysis of deep-sea sediment isolate,
RT Amycolatopsis sp. WP1.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
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DR EMBL; CP015163; AXB43453.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A344L5X9; -.
DR KEGG; aab:A4R43_13610; -.
DR OrthoDB; 7527071at2; -.
DR Proteomes; UP000250434; Chromosome.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Monooxygenase {ECO:0000313|EMBL:AXB43453.1};
KW Oxidoreductase {ECO:0000313|EMBL:AXB43453.1}.
SQ SEQUENCE 424 AA; 46197 MW; 92CF65CD26211D99 CRC64;
MNGPVDLAGV GIGPFNLSLA ALAAGVPELD AVFFERRPGF SWHPGLLIEG TTLQVPFLAD
LVSLVDPTSE LSFLNYLRAK DRLFPFYFAE RFHIPRAEYD DYCRWVSERL PSCRFGRTVT
GVRWEPAENA FALSFAEGDP VLARNVVLGV GTSPKVPEAL RELVAEPGAL AVHSADYLQA
REELLAAPSV TVLGSGQSGA EVFLDLLRAR PHGLRWLSRT RSFAPMEYSK LGLEQFTPDY
TAYFHGLAEP VRDRLVPSQW QLYKGIDAET IAAIHDELYQ LGIGGRWPDV TLTPGVEVVG
AGLADDGIEL RLRHAEQGSS ATVHTGAVVA ATGYTETLSP YTGDCERDRA GRPVVGRDYR
LALPPEVTGS LFVQNAERHT HGVGAPDLGL AAWRSARILN ALGGRTVYRL PERTAFTKFG
LEGS
//
