ID A0A344LHB4_9PSEU Unreviewed; 828 AA.
AC A0A344LHB4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=A4R43_37435 {ECO:0000313|EMBL:AXB47438.1};
OS Amycolatopsis albispora.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis.
OX NCBI_TaxID=1804986 {ECO:0000313|EMBL:AXB47438.1, ECO:0000313|Proteomes:UP000250434};
RN [1] {ECO:0000313|EMBL:AXB47438.1, ECO:0000313|Proteomes:UP000250434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WP1 {ECO:0000313|EMBL:AXB47438.1,
RC ECO:0000313|Proteomes:UP000250434};
RA Wang H., Chen S., Wu Q.;
RT "Complete genome sequence and analysis of deep-sea sediment isolate,
RT Amycolatopsis sp. WP1.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR EMBL; CP015163; AXB47438.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A344LHB4; -.
DR KEGG; aab:A4R43_37435; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000250434; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 2.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:AXB47438.1};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 26..482
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT REGION 785..828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 828 AA; 89676 MW; 42485671A30851F0 CRC64;
MARRKGTTTK IDPAAFDQAG ANVYDNPVKT EIEDSYLEYA YSVIHSRALP DARDGLKPVH
RRILFSMNEN GYRPTHAYVK SSRVVGDVMG KYHPHGDTAI YDAMVRMAQD FSMNVPLIDG
HGNFGSPDDG PAASRYTEAR MSREAMLLVG ELGEDTVDFR PNYDGSLAEP SVLPAAYPNL
LVNGTSGIAV GMATNMIPHN MFEVITAARW LINHPNASLD KLMEFVPGPD LPTGGMLLGL
DEVRKAYETG RGVVRMRAKA ETGPLEGSRG RQAITVTELP YGVGTERIIE KITDEVNKSK
RLTGIADVKD LTDRENGTRL VIECKVGVNP QALLADLYRL TPLEQSFGIN NLVLVDGQPR
TLGLKALLEV FLAHRYDVVT RRTRYRRRKR EERLHLVEGL LKALLNIDKV IKLIRGSENA
QDAKDGLMKQ FKLSEIQATY ILDTPLRRLT KYDRLELEAE QDKLREEIAE LTKILDDESV
LKKVVSSELG KIAKEFSSER RTALIDGDLK EVLAASKPAG PLEVADDPCQ VILSATGLVA
RTAAESEEVS EGRRRNGRAR HDAVAAVVHS TARGQILLVT SRGRAFKTDV LPLPVLPEQV
GTVSLRGGMA ASELVPLEKG ERVIGVAPLG EQAEGSPGLA LGTRNGVVKV CAPEWPVRSD
EFEVISLKDG DEVVGATWLT DGSESLAFLT SQASLLRYSA SLVRPQGLKG GGMAGINVGA
DAHVVFFGAV RTDDGEHGEP MVVTATGQSV KVTPFEEYPA KGRGTGGVRT HRFLKGETGL
AVGWIGPRPA GSSSSGSPVE LPEVDLRRDG SGAAHPGPDV VGHLIERG
//
