ID A0A344LKL6_9PSEU Unreviewed; 1196 AA.
AC A0A344LKL6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=A4R43_17930 {ECO:0000313|EMBL:AXB48590.1};
OS Amycolatopsis albispora.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis.
OX NCBI_TaxID=1804986 {ECO:0000313|EMBL:AXB48590.1, ECO:0000313|Proteomes:UP000250434};
RN [1] {ECO:0000313|EMBL:AXB48590.1, ECO:0000313|Proteomes:UP000250434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WP1 {ECO:0000313|EMBL:AXB48590.1,
RC ECO:0000313|Proteomes:UP000250434};
RA Wang H., Chen S., Wu Q.;
RT "Complete genome sequence and analysis of deep-sea sediment isolate,
RT Amycolatopsis sp. WP1.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP015163; AXB48590.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A344LKL6; -.
DR KEGG; aab:A4R43_17930; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000250434; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 7..74
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1196 AA; 131820 MW; CBC2ADED6DE79360 CRC64;
MSKDSFVHLH VHTEYSMLDG AAKIAPLFAE ASRLGMPAVG MTDHGNMYGA DEFYQQARKA
GITPIIGIEA YVAPESRFHK KPVFWGQSNQ RGADEFGEGG DVSGGGAYTH MTMLAENAAG
LRNLFRLSSL ASLEGYYRKP RMDRELISEH HEGIIATTGC PSGEVQTRLR LGQKAEAIQA
ASDYKDIFGP DNFFLELMDH GLPIERSVRE GLLEIGRQLG IRPLATNDSH YVTRDQADTH
SALLCVQAGK TLNDPNRFKF DGDGYYLKSA AEMREYWDTE VPGAADSTLM IAERVQSYEE
VYAHKDRLPF FEVPEGYDQG AWLREEVQRG LKWRFPNGAP EGYQERLEVE LDVIIGKGFP
AYFLIVADLI NYARRVGIRV GPGRGSAAGS LVAYVLGITN LDPIPQKLLF ERFLNPERVS
MPDIDIDFDD RRRGEMIRYA TDKYGVDKVA QVITFGTIKT KAAIKDAARV HYGQPGYAIA
DKISKALPPP IMAKDIPLSG IVDPKHERYG EAAEVRSLIE TDSEVATIFE TARGLEGLIR
NAGVHACAVI MSSEPLTNAI PLWQRDDGSI ITGWDYPSCE AIGLLKMDFL GLRNLTVIGD
AIDNIKANRG VDIDLDTLGV DDPETYKLLA RGDTLGVFQL DGGPMRDLLR RMQPTRFDDI
VAVGALYRPG PMGMNAHNDY ADRKNGRQNV KPIHPELDEP LKEILADTYG LIVYQEQIMH
IGQKVAGYSM GRADVLRRAM GKKKQEVLEK EFEGFEAGMK ASDLVPGGFS DEAIKALWDT
ILPFAGYAFN KSHAAAYGLI SYWTAYLKAN YTAEYMAALL TSVGDNKDKS AIYLSECRRL
GIKVLPPDVN ESAQRFAAVG DDIRFGMGAV RNVGANVVES IIKTREEKGK YTSFTDFLDK
SELVACNKRV IESLIKAGAF DSMGNTRLSM VQAHEEAVEA VVPLKRQQAM GQFDLFGPMG
DEPDDAAAAA ASSPLAHLKF SDEEYPRKQL LSYEREMLGL YVSAHPLDGA ERILRKHAKK
PIAAILADPP KEGEIVVSGL ITSLERRVNK KGEPWAICTV EDMDASLEVL FFPKSYAIFA
ADLVEDNAVL VKGRVNWREE KMSVFGGGLV PLDLSDAAIG DEEPPLVLLV AAEKLDQSVV
SELKSTLLAH KGDTPAHLKL MGKQGQRMYA LDDYPVRVSS MLMGELKSIQ GITANT
//
