ID A0A344PGC9_9RHOB Unreviewed; 497 AA.
AC A0A344PGC9;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=Metal-dependent carboxypeptidase {ECO:0000256|PIRNR:PIRNR006615};
DE EC=3.4.17.19 {ECO:0000256|PIRNR:PIRNR006615};
GN ORFNames=DRW48_00820 {ECO:0000313|EMBL:AXC48434.1};
OS Paracoccus suum.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Paracoccus.
OX NCBI_TaxID=2259340 {ECO:0000313|EMBL:AXC48434.1, ECO:0000313|Proteomes:UP000252023};
RN [1] {ECO:0000313|Proteomes:UP000252023}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC2-6 {ECO:0000313|Proteomes:UP000252023};
RA Heo J., Kim S.-J., Kwon S.-W.;
RT "Genome sequencing of Paracoccus sp. SC2-6.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Broad specificity carboxypetidase that releases amino acids
CC sequentially from the C-terminus, including neutral, aromatic, polar
CC and basic residues. {ECO:0000256|PIRNR:PIRNR006615}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Release of a C-terminal amino acid with broad specificity,
CC except for -Pro.; EC=3.4.17.19;
CC Evidence={ECO:0000256|PIRNR:PIRNR006615};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR006615-1};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR006615-1};
CC -!- SIMILARITY: Belongs to the peptidase M32 family.
CC {ECO:0000256|PIRNR:PIRNR006615}.
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DR EMBL; CP030918; AXC48434.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A344PGC9; -.
DR KEGG; pars:DRW48_00820; -.
DR OrthoDB; 9772308at2; -.
DR Proteomes; UP000252023; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-UniRule.
DR CDD; cd06460; M32_Taq; 1.
DR Gene3D; 1.10.1370.30; -; 1.
DR InterPro; IPR001333; Peptidase_M32_Taq.
DR PANTHER; PTHR34217:SF1; CARBOXYPEPTIDASE 1; 1.
DR PANTHER; PTHR34217; METAL-DEPENDENT CARBOXYPEPTIDASE; 1.
DR Pfam; PF02074; Peptidase_M32; 1.
DR PIRSF; PIRSF006615; Zn_crbxpep_Taq; 1.
DR PRINTS; PR00998; CRBOXYPTASET.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|PIRNR:PIRNR006615,
KW ECO:0000313|EMBL:AXC48434.1}; Hydrolase {ECO:0000256|PIRNR:PIRNR006615};
KW Metal-binding {ECO:0000256|PIRNR:PIRNR006615,
KW ECO:0000256|PIRSR:PIRSR006615-1};
KW Metalloprotease {ECO:0000256|PIRNR:PIRNR006615};
KW Protease {ECO:0000256|PIRNR:PIRNR006615};
KW Reference proteome {ECO:0000313|Proteomes:UP000252023};
KW Zinc {ECO:0000256|PIRSR:PIRSR006615-1}.
FT ACT_SITE 254
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR006615-2"
FT BINDING 253
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR006615-1"
FT BINDING 257
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR006615-1"
FT BINDING 292
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR006615-1"
SQ SEQUENCE 497 AA; 55750 MW; 670AAB84E3CE3AAB CRC64;
MGQVNDLLNA KSVLSWDARV MMPRGGAETR AKQVATLSVL ARDTLVADET RRLLDAAQAE
IQSKDADSVE ATVCAQVREA LDYHDRIPAE LIRRRTEMGS IGQEIWAEAR AKDDFAMFAP
LLADTVALNR EMAEHIGYAE HPYDALMYRF EPGETVASLQ PLFGRLREAL RPLLQTVMSR
TAPDVEFLRR PFPVDEQLAF GRTMAQRLGY DLDRGRLDTT VHPFEVSFTR NDVRITSRTN
ENWMPMCLFG CLHEAGHALY EQNCDPAFTR TPLATDLVGL YAVAGVSFGA HESQSRLFEN
HVGRSRAFWE ANFGTARDAF PEQLADVDAE AFWRGVNRVA PGLIRVEADE LSYDFHIMLR
VDIEAGLIDG SLKVEDLPEI WNARIRQDLG LEVPNNRMGV LQDVHWSSGQ IGTFCNYTIG
NVMAGQLYEA ATKDADVAAG VAAADYGPLL GWMVKNVHQH GRRYERNELL RRATGRTLDP
EPYIAQLTQK YSEIYGI
//