ID A0A344TYX6_9ACTN Unreviewed; 614 AA.
AC A0A344TYX6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE RecName: Full=Acyl-CoA synthetase {ECO:0000256|ARBA:ARBA00032875};
GN ORFNames=C0216_10585 {ECO:0000313|EMBL:AXE23847.1};
OS Streptomyces globosus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=68209 {ECO:0000313|EMBL:AXE23847.1, ECO:0000313|Proteomes:UP000252004};
RN [1] {ECO:0000313|EMBL:AXE23847.1, ECO:0000313|Proteomes:UP000252004}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LZH-48 {ECO:0000313|EMBL:AXE23847.1,
RC ECO:0000313|Proteomes:UP000252004};
RA Ran K., Li Z., Wei S., Dong R.;
RT "Draft genome Sequence of streptomyces globosus LZH-48.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-
CC CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560,
CC ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024484};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422;
CC Evidence={ECO:0000256|ARBA:ARBA00024484};
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DR EMBL; CP030862; AXE23847.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A344TYX6; -.
DR KEGG; sgz:C0216_10585; -.
DR OrthoDB; 5240489at2; -.
DR Proteomes; UP000252004; Chromosome.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR CDD; cd05907; VL_LC_FACS_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43272:SF32; AMP-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43272; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:AXE23847.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000252004}.
FT DOMAIN 21..436
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
SQ SEQUENCE 614 AA; 66994 MW; E0DE6F27BEFF3415 CRC64;
MSTILRLPGR PEQLTLPALL ARNAAEYGDL PALSWRTGDT ASPGWTTLGW AEVRRRVAVL
AAGYASLGVE RGEHVLIMMG NRPEHWLTDL ALVHLGAVPV TVYGTSAPEQ IAYTARHSRA
RLAVVGGAGE LPRWEPLLAD GTVPLERLVV ADAGAAGAHR SYDAVYTAGT RLHTPDAFEK
AWRELRPEDP LTVVYTSGTT GDPKGVRLTH RNILLQSVRL DRRVELPEHA EHICYLPFAH
IAERILGIYL PLLRAAHVRL VADPAAVAAA VRELRPVQFF GVPRVWEKLA AGLRAVLAGL
PREQREAIEE ANGLARTVAG HLERGEPVPA GPEAAYVRAK EHVLDPLLRL AGLDRLLWTA
SATAPMPIDV VRFWAGWGIT VMDAWGLTET SGVCTVNSRD AFRLGSVGRP IEGLELRIAD
DGEILARGET VFGGYLRPDG TLEGAHDAEG WFPTGDIGRI DQDGFLWLTD RKKELIITST
GKNVSPALVE NTLKEHPLIG QALAHGDRRS YLVALLVLDA ELAPAWAAAR GIEAASLADL
ARHPQVRAEI AAAVETANAR LNRTEQIKRY HLLTTEWGPE TGELTPSLKL RRRVVRDKYA
DTIDSLYTDP PEPR
//