ID A0A344TZX5_9ACTN Unreviewed; 5580 AA.
AC A0A344TZX5;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Acyl transferase {ECO:0000313|EMBL:AXE24196.1};
GN ORFNames=C0216_12670 {ECO:0000313|EMBL:AXE24196.1};
OS Streptomyces globosus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=68209 {ECO:0000313|EMBL:AXE24196.1, ECO:0000313|Proteomes:UP000252004};
RN [1] {ECO:0000313|EMBL:AXE24196.1, ECO:0000313|Proteomes:UP000252004}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LZH-48 {ECO:0000313|EMBL:AXE24196.1,
RC ECO:0000313|Proteomes:UP000252004};
RA Ran K., Li Z., Wei S., Dong R.;
RT "Draft genome Sequence of streptomyces globosus LZH-48.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP030862; AXE24196.1; -; Genomic_DNA.
DR KEGG; sgz:C0216_12670; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000252004; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd08952; KR_1_SDR_x; 1.
DR CDD; cd08956; KR_3_FAS_SDR_x; 2.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 3.30.70.3290; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 3.40.50.11460; -; 1.
DR Gene3D; 6.10.140.1830; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR036299; Polyketide_synth_docking_sf.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 3.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 3.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF21089; PKS_DH_N; 2.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00827; PKS_AT; 3.
DR SMART; SM00826; PKS_DH; 2.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 3.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF101173; Docking domain B of the erythromycin polyketide synthase (DEBS); 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 7.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 3.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 3.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000252004};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AXE24196.1}.
FT DOMAIN 33..466
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1490..1565
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1585..2011
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3625..3700
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3720..4147
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 5411..5486
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 4150..4197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 4..31
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 5580 AA; 573955 MW; 9315F103BED20C1C CRC64;
MSNEQKLRDY LKRAIADLDE TREQLREVQE KSREPIAIVG MACRYPGGAD TPEQLWELVR
GGVDAVSAFP ADRGWNLEDL YGGAEAEGGD GAAYPRESGF LHGAGDFDAG FFGISPREAL
AMDPQQRLML ETAWEAVERA GISPHALRGT HTGVFIGAGH GGYDTAATAG SGRIREEVAG
HVLTGNTVSV ASGRISYVLG LEGPAVTVDT ACSSSLVALH LAVQSLRRGE CTLALAGGVT
VMSTPQMFAE FGRQRGLAAD GRCKPFSAAA DGTAWSEGAG VILVERLSDA LRAGHPVLAV
VRGSAVNQDG ASNGLTAPNG PSQQRVIRRA LADAGLAATD VDTVEAHGTG TRLGDPIEAT
ALLATYGQGR PADRPLLLGS MKSNIGHTQA AAGVAGVIKT VLAMRHGTLP ATLHLDEPSP
HVDWTAGSVR LLTEEAAWPA HEDRPRRAAV SSFGVSGTNA HVVLEQPATA PPAATGGGTD
ASGVLPWVLS AKTAEALRAQ AARLAAHVRG HAEPSTADIA FSLATTRAAL EHRAAVVGGD
RADLLSGLDA LADGEGTTAL AAKGPLSVLF TGQGSQRLGM GRELYARFPV FAQAFDAVCA
ELDVPVREVV WGEDAEALNQ TMYAQAALFA VEVALFRLVE SWGVRPDFVA GHSIGEVAAA
HVAGVFSLAD ACALVSARGR LMQALPEGGA MLAVAAAEDE VLPLLGESVS IAAVNGPSAV
VVSGAEDAVD AVRAHFEGLG RKTTRLRVSH AFHSPLMDPM LDGFRTVVAG LSFGIPAIPL
VSNLTGQLAS TRELCTPDYW VRHVREAVRF GAGIRTLADL GVTTYLELGP DGVLSALASD
TAGGGGAALV PALRKGTDEE TSLVRALARL HVHGAEVDWS AFYAGTDARP VELPTYAFQH
QHYWLPNSAT DLLRGGSSAT PADAVETAFW EAVERGDLDA ASAVLGIEGA PVQASLDDLL
PVLGTWRAHR RTRAATDAWA YRTTWTAAPH GSATALRSGS GWLAVVPDHS ADDEALAALL
SALTGLGARV ERLVVPAAAG ADSLAESVRT ALADATATGP VSGVLSFLSF DERPHPAHPA
VPRGLPATVD LLRALEASGA GARLWCLTRG AVSVDAAQPP AAPVQAQTWG LGRVAALEYP
QRWGGLIDLP AALGGHDLAA RVAGVLGAGT AEDQIAVRPS GTYVRRLARV VPAHDTESWT
APRGTVLVTG GTGALGGRVA RWLAGAGAEH LLLTSRRGPA ADGAAELAAE LEASGVRVTV
AACDTADRDA LTALLADLPA ELPLSGVVHA AGVLDDGVLD ALTGERFETV LRAKAESARL
LDELTRDPQG GSQLSMFVLF SSISGVLGNA GQGNYAAANA YLDALAEQRR AAGLPATSVA
WGSWADAGMA VGSDALADRI RRSGIVPMDP ELALAALRQA LARGAACVTV ADIDWDTLAP
ALTAARPSPL IGDLPEVRRG PERIAEKDGG KTSPLRERLL GLATPAEQER ALTDLLREEI
ARVLGHASAG TVDANRAFRE LGFDSLTAVE LRNRLTAVTG VPLPATLLFD HPTTAAVAAH
LRAELLDGHT AVAADAAVAV RAEADEPIAI VGMACRFPGG IGSPEEFWEL LARGGDGISD
LPTDRGWDTE GLYDPDPEHH GTSYVREGGF LTGLAGFDAD FFGISPREAL AMDPQQRLLL
ETAWETVERA GIAPDTLRGT ATGVFVGSNF QDYQQVLGTA PDDVTGHLMT GNAASVVSGR
VSYAFGFEGP AVTVDTACSS SLVSLHLAAQ ALRRGECTLA LAGGVTVMST PQVFVEFSRQ
RGLAPDGRCK PFAGAADGTG WAEGVGLLLV ERLSDARRNG HTVLAVLRGS AVNQDGASNG
LSAPNGPSQQ RVIRQALADA GLGADEVDAV EAHGTGTRLG DPIEAQALLA TYGQGRPADR
PLLLGSVKSN IGHTQAAAGV AGVIKMILAL RNGLLPQSLH IDEPSPHVDW SAGAVELLAA
PTAWPAAGRP HRAGVSSFGI SGTNAHVILE AADPLPPAAA TAPEGGGAAT AAAADAAAEA
AISGEAARPQ PSPTLPYVLS AKSPQALAAQ AARLAAHLRG AGAATEPAAV AHALATTRTT
MEHRATVVAD HAAALLAGLD ALAEGRGQAS PAVLEGVADS DGDTVFVFPG QGSQWPGMAL
ELLDTAPVFA ARMAECAAAL DAYTDWSLMD VLRGAEGAPG LDRVDVVQPV LFAVMVSLAE
LWQAHGVRPA AVVGHSQGEI AAACVAGALT LDDAARVVAL RSRALTALSG QGGMVSVARP
ADEVRALLAP WGERLSLAAV NGPSSVVVSG EPEALDALLD ACDRDGIRAK RIPVDYASHS
AQVARIEAEL RTVLAPVAPR AARIPLYSTV TGAPVDTTLL DAAYWYANLR GTVEFEQATR
ALLDAGHRVF IEVSPHPVVT TGVQETIEAA DSAAAATGTL RRDEGGPARF VLSLADARNH
GARIDWDAFF ETAGTPRPGT PAPLPTYAFQ HRRYWPRPAT GGAGDVASAG LGSFDHPLLG
AALPLAIGDE LVATARWSLL SHPWLADHMV GGTVIVPGAA LVEVAVRAGD ELGCGRIEEL
TLHAPVLLPE HGGIQVQIAV GAADPSGLRT VTVHTRPDGE PEAEWTHHAD GTLGAPGAEP
AGEVFAAWPP RGAEPAPETD GLYASLRSEG YAYGPVFQGL RAAWRLDADV YAEAALPEAA
LADAARFGIH PALLDAALHA AGLGPLSNAE GSTGLPFSWT GVTLHATGAT ALRVRLSPAG
PGAVSVLMAD PLGRPVATIE ALAVRPIEAA ALGAADADSR TVRDALFHLD WTPLQAASAP
STAQTGPAGA ARWALLGSET GQAAALTEGG AALARWDSLA DLAAALPATG IPDALLLTAE
AAAGHAADPA ARAAAVLETV LATLQDWLAD ERFDTTRLVV ATRGAVTPDP GGDVTDLPGS
ALWGLLRSAQ TENPGRIVLA DLDDDPASWR ALPQAVAATG EPQLALRQGA AYAPRLARTH
ASGALTAPDG TAAWRLDIPE KGSLDHLALL PAPQASAPLA PGQVRIEVRA AGLNFRDVLN
ALGMYPGGAE FLGSEAAGVV VETAPDVTGL NVGDRVFGMV VGGFGPLAVA DGRVVTRMPA
GWTFAQAAAA PVVFLTAYYA LRDLAGLTEG ETVLVHAAAG GVGMAATQLA RLWGAEVYGT
ASEPKQRLLR AAADGLPADR LASSRTLDFE EAFRAASGGR GVDVVLNSLA GEYVDASLRL
LAPGGRLVEM GKTDIRDAAD VARDHDGAFY RAFDLAEAGP ERIGEMLTEL VALFEQGALR
PLPVTAWDLA HAPDAFRYVS QARHTGKVVL TVPRPWNPDG TVLITGGTGE LGRALARHLV
TAHGMRHLLL AGRRGPDSPG AAELRSELAE LGAEVTLAAC DTADRAALAA LLASVGADHP
LTAVVHAAGV LDDGVVTSLT PERLATVLRP KADAAWNLHE LTRHLDLAGF VLFSSAAGTF
GNAGQGNYAA ANTFLDGLAR HRQTAGLPAT SLAWGLWAQA SGMTGHLDEG DRSRARSTGA
LPLATRDGLT LFDAALAARR PLLVPLRLDG AVLRRRAPEA LPPILRTLFR GTAARRAAEA
GPGTAVPGGG LRHRLAALPA AERQTALVEL VTTYAVAVLG HADAGLIHAG KAFRDLGFDS
LTAVELRNRL GTAAGLRLPA TLVFDHPTPV ALAEHLGGLL ADTAPTAEAA TAPLTAAPDE
DPVVIVGMAC RYPGGVRSPE DLWTLLADGT DAIGGFPTDR GWDLEHLYDS VPDHPDASRT
LEGGFLHDAA EFDADFFGIS PNEATVMDPQ QRLLLETAWE AAERAGIDPR SLRGSRTGVF
AGLSSSDYMS RGADVPEALA GYVNTGNAVS VVSGRVSYAL GLEGPAVTVD TACSSSLVAL
HMAAQALRAG ECSLALAGGV TVMSSPAVIV DFSRQRGLAA NGRCKPFSAD ADGTGFSEGA
GLLVLERLSD AVRAGRQVLA VVRGSAVNQD GASNGLSAPN GPSQQRVIRQ ALANAGLTGA
DVDAVEAHGT GTRLGDPIEA QALLATYGQE RDADRPLRLG SVKSNLGHTQ AAAGVAGVMK
MVLAMRHGTL PKSLHADEPT PHVDWPAGAV RLLDEAAAWP ASDDRPRRAG VSSFGISGTN
AHVILEQGPD AASSPAAASG GAGEPGTTAP AGAEPQAAPA AVPGTPEPAA AAAAGPAAPA
EAAARPLPWL LSARSAPALR AQAAALLAHL DTPAGRRSTP LDLAASLATR RAVLEHRAVV
TAADPATLRS ALAGLADGTP AAGLVQGRHT SGRDRRTVLV FPGQGSQWAG MGAGLLDSSP
EFATRIAACE QALAPYADWS LTAVLREEPG APPLDRVDVA QPALWAVMVA LAEVWQAHGV
RPAAVVGHSQ GEIAAACVAG ALSLEDGARV VALRSRAIAA HLSGHGGMVS VAASHEDVLA
RLTAWGERIS VAAVNGPGSV VVSGEPDALD ALVDACTRDG VRARKIPVDY ASHSAQVERI
RETVLADLAG IETGEPRIPF LSTLTGEWIG ADTALDASYW YENLRRTVRL EDALRTLLAQ
GHDVFVESSP HPVLTAAIED TVAAAGADAR TLGSLRRQDG GPERMLASLA EAHVHGVRVD
WSGVLGGRRA ADLPTYAFQR SRYWLDAAPA AAAAGPADPS GLDGVVRLAD GDGSLVLTGR
IGAATHPWLA DHTVHGSAVV PATALLDWAV RAADEAGCAV VEDLTELVPL AVPEDGTAEV
QLTVAAAEAG TRRLAVHART GADEDWTRHA TGTLSRAALP AGEPFDTTDW PPHGARPADT
EELYAVLAEG GYDPGPLHRT VRALWTAPDG GTLAEVALPQ EQHQAASAFR IHPALLQTVL
AMAAGRSGRA ELPTTWHAVN LTATGAAHLR VRITRTRDGA LSLTAADATG APVLTAGAVT
TGAPAAAARH PQALFETAWT EPDWAPAAEA LAEPATGTAS FTGLPALLEA LGTEHADAFA
DTVLLRLPAA GDLAAPADPA DSTPVREMLH LAQTWLADPR CADSRLVLVT AGAGAALTDA
AVHGLIRSAQ AEHPGRFLLV DTDGDPASER ALPAAVAAAA AADEAHLALH AGTVTVPRLR
HAAPPQDPSG LPALEWDVHG DGTVLITGGT GTLGAHVARH LVTGHGVRHL LLTGRRGPDA
PGAAELRDEL TRLGATVTIA ACDAADRDAL AGVLAAIPAE HPLTAVVHAA GVLRDGLLEN
LTAEDLDHVW RPKAEAAWHL HELTRDTKLS AFVLFSSFAG VIGGPAQANY AAANSFLDAL
AHRRRAEGFT AVSLAWGYWG DSSEMTSRLD PVDVARFARS GMLPLSAGQG LGLLDAAAAL
DRALLVPVRL DPRAWSAAGR APALLRALAP VPAVVRRSAS TPGATAPADG TRHDGGFTER
LAGLGEAKRE ELLLQLIAGH AATVLGHGSP ASIDAERGFL DLGMSSLTAV ELRNRLNAET
GLRLPTTAVF DHPTPLALAR HLRAQLASAD GTEPDGSLLP GLDELERALT AGAASALDAD
SRARLTARLK ALQWKLDDTV DHTAEGTGGD ADGTGADADL EAASTDDEIF DLIDKELGLA
//
