ID A0A344UAT5_9ACTN Unreviewed; 2325 AA.
AC A0A344UAT5;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:AXE28006.1};
GN ORFNames=C0216_31350 {ECO:0000313|EMBL:AXE28006.1};
OS Streptomyces globosus.
OG Plasmid unnamed2 {ECO:0000313|EMBL:AXE28006.1,
OG ECO:0000313|Proteomes:UP000252004}.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=68209 {ECO:0000313|EMBL:AXE28006.1, ECO:0000313|Proteomes:UP000252004};
RN [1] {ECO:0000313|EMBL:AXE28006.1, ECO:0000313|Proteomes:UP000252004}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LZH-48 {ECO:0000313|EMBL:AXE28006.1,
RC ECO:0000313|Proteomes:UP000252004};
RC PLASMID=unnamed2 {ECO:0000313|EMBL:AXE28006.1,
RC ECO:0000313|Proteomes:UP000252004};
RA Ran K., Li Z., Wei S., Dong R.;
RT "Draft genome Sequence of streptomyces globosus LZH-48.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP030864; AXE28006.1; -; Genomic_DNA.
DR KEGG; sgz:C0216_31350; -.
DR OrthoDB; 3488622at2; -.
DR Proteomes; UP000252004; Plasmid unnamed2.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd08953; KR_2_SDR_x; 1.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF21089; PKS_DH_N; 2.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 2.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Plasmid {ECO:0000313|EMBL:AXE28006.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000252004};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 295..374
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 833..1254
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2163..2238
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 280..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2325 AA; 243159 MW; 960918308EA4782F CRC64;
MNLLDGLTCT VVVRGTDPVL RDHRVHGTRI LPGVSFLDMI YRILRARGVD TSRVELRRVL
FRNPVAAGPD FDTELRLQFS ADAEGHRVLV TGTRRPTGET EPVLDCRLHL DVPFPAEAVD
LSALRAGLPR TADMADLYAL VRRTGIEHGA FMRARGTLHV GERELLADLA LGPEAAAYAE
YFHLHPAALD SSTLLPTQFA AAGADEGARP YIPMLIDSFR ARGPLGSRTL VHATPPRATG
PDGDLTTCDL RFLDADGAVR LWLRGLTSKR VREEDAITRL DGAPRAAEPA ATAEAGAAPD
QRTAASLVHG LLAERLGRTA FDEEAGFYEL GLDSTALLGI AADLERAYGT DFSPTLLFEH
STFEDLVAYL GAYELPADGA RRAVGAPQEQ TAAGDAGEEA PSEVVWFEPR WRDAPLPPVQ
DPAPAPVLTV DSRTGRDAEA LLTGHEAADV LWIPADPHDV EGEAVALTGF AAALLRTRRG
PARIVCQVPP GAEVSAVSAL LHTLHREQPG VRAAVVCSPE RADALAELAA GVPDTEVRYE
AGRRQVREVL PVPAPDRPAA LRDRGVYLIT GGLGGVGLSL ARHLARTVRA RLVLCGRTAG
DSTRTAALSA ELTALGAEVQ VVGADVSRAE DVHRAVGLAL SRYGALHGVV HAAGVLRDGL
IAGKSAADVR AVLAPKVTGA RLLYEATRDL GLDFLVLCSS TAGAWGNRGQ ADYACANAFL
DRFAEGRPGV VSIGWPGWSD GGMPLDDRAL RLMGLRGMDT PTAVDIMLRA VGSGRPHLVA
LVGSASEITE RFTPAAAAPA VPAPAPADSE EAAPAPHPPA VGARARARAG DADDAIAVVG
ISGRYPGART LDAFWENLKA GRDGITEVPA DRWDHRTIHS DAKGVPGRSY GRWGGFVDGI
DEFDAAFFHI SPNEAAVLDP QERLFLQEAW HAFEEAGHAP SAWRGRSVGV FAGVMYNQYQ
LHGVGGEPGL VPSSFSASIA NRVSYFLDLK GPSIALDTMC SSSLTALHLA VEAIRGGACE
AALAGGVNLH VHPNKYLLLS QSSFLSTDGR CRAFGEGGDG YVPGEGVGVV LLRPLRDALR
DGDHVHAVIR GTALNHGGRT GGFSVPDPAS QAALVRDSLT AAGVDPADLG YLEAHGTGTS
LGDPIEITAL ERAFDALGAG RGPWPIGSVK SNIGHLESAA GIAALTKVVL QMRHRTLAPS
LHAERLNPAV DWEGSRFRVQ RTPAPWNPPA GAPLTAAISS FGAGGANAHV VLAEHPAVPG
PQATEEDRPR LFVLSAKDAA RLDETAARML AHLDRAGRGA DPEVVERIVA EAVGLRADPG
EPFAELGLDY PRLTALARRV EEEFGVRLHI DAGTTPAELA GRLAGTGTGT DPAALAFTLW
SGRDHLDERL AVVATTAAEF ADALRTGKGC HRGRRRRGAA PVHGGDLHEL ARAWVDGAEI
SLPAPGRPRR LSLPGYPFAR DRHWVATART PSAPLPGTTE EVELPDGHVF GERITTTRQP
WLADHTVDGA VLVPGTYFVD LALRAGARLH CPRIAELVTH TPLATTEADL RLVADLPGPD
GTRAFTIHAR TGDGGWTSHV TGVLAPSPEE PPASAAVPAD AEEIDVTGLY RTLTGYGPAF
RGLHGARRTA DAVFADVAVP GEAAGGAPGA HALHPVLLDA ALHTVALTSA LDGDTPYLPF
AWSGVRVHAP AATAARVRLV HHRPDTVGLL LTDQAGAPVA SVDSVVLRRA DAPDEPLHHV
EWLPVEAPEP SPGARYAVVG PDPEGIGTAL EASGAVLVRA ADLDALTDVP PVVVLPVPAS
PAGPAEAAQA ARALAAEVLD RLRQWLAGRR FASARLVLVT TAPGPATAAA WGLVRSAQSE
HPGRFGLVDA EDLAPLHRAL GSDEPHIRLR DGQVLGARLV RVPAAAPAPA PRAEGTVLVT
GASGALAGPV VRHLVERHGV RDLLLVSRSG AVPAALDGLD ARVESAACDV ADRAALRTLL
AGRRVTMAVH AAGVLDDGVV TALDADRLER VLRPKTEGAA HLAELLPEAQ LVLFSSVAGV
LGGPGQGNYA AANAFLDALA RQHAAAGRRA VSVAWGPWAL DEGMAADRDR MARGGIEPLP
TGAALALLDA ALAGPHPAVT ALRLARGPAT AVPHVLRSLV HTPAAAPAAD PGLAGLGPDE
RRARLSALVR GQAAAVLGYA DAGLIESDRS FQELGFDSLS SIEFRNRLGA ALGMTLEATL
VFDHPTPADL VAHLDERFAG ASEAADLPTL FAAFDRLAAA LTEAAADDVS RDRTAERVRG
LLEQLTPRTA TESVTAFASA TDDEVFALID AELGSPLPGL EERSR
//
